YGR239C / PEX21

Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR239C / PEX21

Click on Significant Values for Screen Details ID:SGTC_108|Compound:0509-0257|FD-Score:-3.61|P-value:1.62E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:4.37|P-value:1.03E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:-3.76|P-value:9.16E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.75|P-value:1.33E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.21|P-value:9.29E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.43|P-value:3.14E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.63|P-value:1.51E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.29|P-value:6.97E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.24|P-value:8.29E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.20|P-value:9.40E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.65|P-value:1.90E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.43|P-value:4.30E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.38|P-value:5.11E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.19|P-value:9.73E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.41|P-value:8.56E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:4.05|P-value:3.96E-5 ID:SGTC_1603|Compound:st002045|FD-Score:3.39|P-value:4.87E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.77|P-value:1.22E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.64|P-value:1.98E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-4.05|P-value:2.86E-5 ID:SGTC_2327|Compound:6189656|FD-Score:-4.07|P-value:2.65E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.01|P-value:4.73E-5 ID:SGTC_2643|Compound:anethole|FD-Score:3.64|P-value:1.99E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:3.25|P-value:7.96E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.26|P-value:5.88E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.51|P-value:3.81E-6 ID:SGTC_2783|Compound:7738165|FD-Score:4.40|P-value:8.87E-6 ID:SGTC_2795|Compound:7780010|FD-Score:3.66|P-value:1.89E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.81|P-value:1.04E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.35|P-value:4.20E-4 ID:SGTC_2911|Compound:7942208|FD-Score:3.57|P-value:2.60E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.19|P-value:7.34E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.10|P-value:9.97E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.61|P-value:1.62E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:4.37|P-value:1.03E-5 ID:SGTC_125|Compound:0133-0007|FD-Score:-3.76|P-value:9.16E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.75|P-value:1.33E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.21|P-value:9.29E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.43|P-value:3.14E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.63|P-value:1.51E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.29|P-value:6.97E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.24|P-value:8.29E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.20|P-value:9.40E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.65|P-value:1.90E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.43|P-value:4.30E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.38|P-value:5.11E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.19|P-value:9.73E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.41|P-value:8.56E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:4.05|P-value:3.96E-5 ID:SGTC_1603|Compound:st002045|FD-Score:3.39|P-value:4.87E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.77|P-value:1.22E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.64|P-value:1.98E-4 ID:SGTC_2324|Compound:6149169|FD-Score:-4.05|P-value:2.86E-5 ID:SGTC_2327|Compound:6189656|FD-Score:-4.07|P-value:2.65E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.01|P-value:4.73E-5 ID:SGTC_2643|Compound:anethole|FD-Score:3.64|P-value:1.99E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:3.25|P-value:7.96E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.26|P-value:5.88E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.51|P-value:3.81E-6 ID:SGTC_2783|Compound:7738165|FD-Score:4.40|P-value:8.87E-6 ID:SGTC_2795|Compound:7780010|FD-Score:3.66|P-value:1.89E-4 ID:SGTC_2844|Compound:9010103|FD-Score:3.81|P-value:1.04E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-3.35|P-value:4.20E-4 ID:SGTC_2911|Compound:7942208|FD-Score:3.57|P-value:2.60E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.19|P-value:7.34E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.10|P-value:9.97E-4

Top fitness defect scores for YGR239C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1378 2093-0007 4.41 380.0 nM 8.56E-6 11 5.11E-6
2 SGTC_2783 7738165 4.40 71.4 µM 8.87E-6 21 5.30E-6
3 SGTC_123 0083-0120 4.37 66.7 µM 1.03E-5 37 6.17E-6
4 SGTC_1527 coumarin 4.05 137.0 µM 3.96E-5 23 2.52E-5
5 SGTC_2575 plumbagin 4.01 510.0 nM 4.73E-5 superoxide 36 3.03E-5
6 SGTC_2844 9010103 3.81 26.0 µM 1.04E-4 37 6.87E-5
7 SGTC_1792 st045773 3.77 43.6 µM 1.22E-4 32 8.10E-5
8 SGTC_260 nsc-65238 3.75 4.0 µM 1.33E-4 endomembrane recycling 20 8.88E-5
9 SGTC_2795 7780010 3.66 54.5 µM 1.89E-4 39 1.28E-4
10 SGTC_787 4152-0075 3.65 138.0 µM 1.90E-4 29 1.29E-4
11 SGTC_2266 7929956 3.64 200.0 µM 1.98E-4 43 1.34E-4
12 SGTC_2643 anethole 3.64 100.0 µM 1.99E-4 21 1.36E-4
13 SGTC_2911 7942208 3.57 15.6 µM 2.60E-4 mitochondrial response to ROS 24 1.79E-4
14 SGTC_940 3232-1287 3.43 54.8 µM 4.30E-4 NEO1 58 3.02E-4
15 SGTC_1603 st002045 3.39 67.8 µM 4.87E-4 TSC3-RPN4 33 3.44E-4
16 SGTC_1065 prochlorperazine maleate 3.38 2.5 µM 5.11E-4 28 3.62E-4
17 SGTC_521 r062-0005 3.29 13.8 µM 6.97E-4 35 5.00E-4
18 SGTC_2652 actinonin 3.25 100.0 µM 7.96E-4 13 5.74E-4
19 SGTC_733 4069-0007 3.24 56.1 µM 8.29E-4 ERAD & cell cycle 123 5.99E-4
20 SGTC_272 doxorubicin 3.21 8.1 µM 9.29E-4 anthracycline transcription coupled DNA repair 57 6.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.67E-15 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.103 2.44E-9 YLR214W FRE1 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
0.101 4.16E-9 YMR300C ADE4 hom Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
0.097 1.83E-8 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.096 2.70E-8 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
0.092 1.00E-7 YLR058C SHM2 hom Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
0.090 2.00E-7 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.089 2.09E-7 YNL039W BDP1 het Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
0.087 4.31E-7 YIR029W DAL2 hom Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.086 6.04E-7 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.086 6.74E-7 YJR096W YJR096W hom Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.085 7.08E-7 YGL234W ADE5,7 hom Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
0.085 7.15E-7 YCL016C DCC1 hom Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
0.085 8.66E-7 YGR061C ADE6 hom Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.085 9.20E-7 YOR270C VPH1 hom Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress