YGR244C / LSC2

Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR244C / LSC2

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.31|P-value:3.97E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.68|P-value:1.24E-6 ID:SGTC_393|Compound:acivicin|FD-Score:3.83|P-value:5.88E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.35|P-value:3.36E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.43|P-value:4.11E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:3.22|P-value:5.98E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-3.08|P-value:8.70E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.17|P-value:7.19E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.44|P-value:2.45E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.14|P-value:7.23E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.97|P-value:2.78E-7 ID:SGTC_1115|Compound:galangin|FD-Score:-4.16|P-value:1.26E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.46|P-value:2.46E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.90|P-value:4.41E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.40|P-value:3.12E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.13|P-value:7.49E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.72|P-value:8.15E-5 ID:SGTC_1753|Compound:st043925|FD-Score:3.18|P-value:6.93E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-3.30|P-value:4.09E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-3.40|P-value:2.81E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.78|P-value:7.16E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:5.58|P-value:9.54E-9 ID:SGTC_1939|Compound:st074455|FD-Score:7.10|P-value:4.01E-13 ID:SGTC_1948|Compound:st076329|FD-Score:-5.69|P-value:4.12E-9 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.13|P-value:8.21E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.79|P-value:6.93E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.87|P-value:5.02E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.71|P-value:1.03E-6 ID:SGTC_2112|Compound:5488546|FD-Score:-3.56|P-value:1.54E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.97|P-value:3.19E-5 ID:SGTC_2126|Compound:5251174|FD-Score:-3.32|P-value:3.77E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.55|P-value:1.59E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.10|P-value:9.20E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.89|P-value:4.02E-5 ID:SGTC_2384|Compound:9036245|FD-Score:-3.19|P-value:6.03E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.67|P-value:9.99E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:4.38|P-value:5.09E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.60|P-value:8.33E-9 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.38|P-value:4.59E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.51|P-value:1.85E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.32|P-value:3.76E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.63|P-value:1.58E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.60|P-value:1.79E-6 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.23|P-value:5.25E-4 ID:SGTC_2833|Compound:9001315|FD-Score:7.39|P-value:4.61E-14 ID:SGTC_2889|Compound:9059656|FD-Score:3.18|P-value:6.97E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.33|P-value:4.05E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-3.32|P-value:3.84E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.12|P-value:7.59E-4 ID:SGTC_3068|Compound:9116768|FD-Score:4.95|P-value:3.04E-7 ID:SGTC_3190|Compound:9110366|FD-Score:3.34|P-value:3.89E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.09|P-value:9.61E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.11|P-value:8.82E-4 ID:SGTC_3299|Compound:9121982|FD-Score:8.59|P-value:2.29E-18 ID:SGTC_3302|Compound:9125395|FD-Score:5.70|P-value:4.53E-9 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.31|P-value:3.97E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.68|P-value:1.24E-6 ID:SGTC_393|Compound:acivicin|FD-Score:3.83|P-value:5.88E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.35|P-value:3.36E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.43|P-value:4.11E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:3.22|P-value:5.98E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-3.08|P-value:8.70E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.17|P-value:7.19E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.44|P-value:2.45E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.14|P-value:7.23E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.97|P-value:2.78E-7 ID:SGTC_1115|Compound:galangin|FD-Score:-4.16|P-value:1.26E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.46|P-value:2.46E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.90|P-value:4.41E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.40|P-value:3.12E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.13|P-value:7.49E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.72|P-value:8.15E-5 ID:SGTC_1753|Compound:st043925|FD-Score:3.18|P-value:6.93E-4 ID:SGTC_1765|Compound:st044815|FD-Score:-3.30|P-value:4.09E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-3.40|P-value:2.81E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.78|P-value:7.16E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:5.58|P-value:9.54E-9 ID:SGTC_1939|Compound:st074455|FD-Score:7.10|P-value:4.01E-13 ID:SGTC_1948|Compound:st076329|FD-Score:-5.69|P-value:4.12E-9 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.13|P-value:8.21E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.79|P-value:6.93E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.87|P-value:5.02E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.71|P-value:1.03E-6 ID:SGTC_2112|Compound:5488546|FD-Score:-3.56|P-value:1.54E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.97|P-value:3.19E-5 ID:SGTC_2126|Compound:5251174|FD-Score:-3.32|P-value:3.77E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.55|P-value:1.59E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.10|P-value:9.20E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.89|P-value:4.02E-5 ID:SGTC_2384|Compound:9036245|FD-Score:-3.19|P-value:6.03E-4 ID:SGTC_2434|Compound:5670830|FD-Score:-3.67|P-value:9.99E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:4.38|P-value:5.09E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.60|P-value:8.33E-9 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.38|P-value:4.59E-6 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.51|P-value:1.85E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.32|P-value:3.76E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.63|P-value:1.58E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:4.60|P-value:1.79E-6 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.23|P-value:5.25E-4 ID:SGTC_2833|Compound:9001315|FD-Score:7.39|P-value:4.61E-14 ID:SGTC_2889|Compound:9059656|FD-Score:3.18|P-value:6.97E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.33|P-value:4.05E-4 ID:SGTC_2967|Compound:9089538|FD-Score:-3.32|P-value:3.84E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.12|P-value:7.59E-4 ID:SGTC_3068|Compound:9116768|FD-Score:4.95|P-value:3.04E-7 ID:SGTC_3190|Compound:9110366|FD-Score:3.34|P-value:3.89E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.09|P-value:9.61E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.11|P-value:8.82E-4 ID:SGTC_3299|Compound:9121982|FD-Score:8.59|P-value:2.29E-18 ID:SGTC_3302|Compound:9125395|FD-Score:5.70|P-value:4.53E-9

Top fitness defect scores for YGR244C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3299 9121982 8.59 43.1 µM 2.29E-18 3 4.32E-18
2 SGTC_2833 9001315 7.39 45.5 µM 4.61E-14 amide catabolism 8 7.27E-14
3 SGTC_1939 st074455 7.10 53.6 µM 4.01E-13 3 6.08E-13
4 SGTC_3302 9125395 5.70 16.4 µM 4.53E-9 1 5.84E-9
5 SGTC_2566 crystal violet carbinol 5.60 226.0 nM 8.33E-9 12 1.06E-8
6 SGTC_1929 genistein trimethyl ether 5.58 50.5 µM 9.54E-9 2 1.22E-8
7 SGTC_1099 5-nonyloxytryptamine 4.97 2.9 µM 2.78E-7 6 3.34E-7
8 SGTC_3068 9116768 4.95 49.5 µM 3.04E-7 7 3.65E-7
9 SGTC_2042 p-Dimethylaminoacetophenone 4.71 200.0 µM 1.03E-6 6 1.21E-6
10 SGTC_391 gliotoxin 4.68 8.3 µM 1.24E-6 45 1.45E-6
11 SGTC_2636 apigenin dimethyl ether 4.63 100.0 µM 1.58E-6 25 1.85E-6
12 SGTC_2768 sulfasalazine 4.60 50.2 µM 1.79E-6 7 2.09E-6
13 SGTC_520 3584-0023 4.43 682.0 µM 4.11E-6 16 4.73E-6
14 SGTC_2563 tomatine 4.38 8.5 µM 5.09E-6 28 5.84E-6
15 SGTC_2118 5526350 3.97 200.0 µM 3.19E-5 18 3.55E-5
16 SGTC_1288 0973-0013 3.90 65.5 µM 4.41E-5 15 4.89E-5
17 SGTC_2036 5160441 3.87 105.0 µM 5.02E-5 NEO1 83 5.55E-5
18 SGTC_393 acivicin 3.83 6.2 µM 5.88E-5 25 6.48E-5
19 SGTC_1980 st071811 3.79 45.7 µM 6.93E-5 RPP1 & pyrimidine depletion 21 7.62E-5
20 SGTC_1869 3',7'-dimethoxyflavone 3.78 40.3 µM 7.16E-5 32 7.88E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 6.47E-22 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.142 1.82E-16 YFL040W_p YFL040W_p hom Putative transporter, member of the sugar porter family; YFL040W is not an essential gene
0.117 8.78E-12 YOR279C RFM1 hom DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
0.107 5.05E-10 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.104 1.48E-9 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.103 2.31E-9 YBR145W ADH5 hom Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication
0.100 5.88E-9 YPL245W_p YPL245W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.100 6.70E-9 YLR077W FMP25 hom Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria
0.100 6.94E-9 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.097 1.70E-8 YOL031C SIL1 hom Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
0.094 5.32E-8 YPR035W GLN1 het Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.091 1.48E-7 YDL212W SHR3 het Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
0.090 1.98E-7 YPL061W ALD6 hom Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
0.087 3.98E-7 YBR221C PDB1 hom E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
0.087 4.67E-7 YJR094W-A RPL43B hom Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress