HIPHOP chemogenomics database
YGR246C / BRF1 
TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YGR246C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.143 | 1.06E-16 | YKL164C | PIR1 | hom | O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication |
| 0.136 | 2.53E-15 | YDL008W | APC11 | het | Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity |
| 0.111 | 1.42E-10 | YGL249W | ZIP2 | hom | Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress |
| 0.103 | 1.86E-9 | YMR017W | SPO20 | hom | Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog |
| 0.103 | 1.93E-9 | YCR102W-A_d | YCR102W-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.098 | 1.33E-8 | YFL063W_d | YFL063W_d | hom | Dubious open reading frame, based on available experimental and comparative sequence data |
| 0.097 | 1.64E-8 | YGR276C | RNH70 | hom | 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts |
| 0.097 | 1.78E-8 | YGR068C | ART5 | hom | Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane |
| 0.097 | 2.16E-8 | YDR048C_d | YDR048C_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.095 | 3.21E-8 | YPR012W_d | YPR012W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene |
| 0.095 | 3.36E-8 | YDR469W | SDC1 | hom | Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 |
| 0.092 | 9.06E-8 | YDR434W | GPI17 | het | Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog |
| 0.091 | 1.29E-7 | YER171W | RAD3 | het | 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress |
| 0.091 | 1.29E-7 | YDR390C | UBA2 | het | Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability |
| 0.090 | 2.08E-7 | YEL040W | UTR2 | hom | Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck |