YGR250C

Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR250C / YGR250C

Click on Significant Values for Screen Details ID:SGTC_107|Compound:0358-0022|FD-Score:-3.50|P-value:3.16E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.77|P-value:1.17E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.80|P-value:1.02E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.68|P-value:1.64E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.63|P-value:2.99E-6 ID:SGTC_552|Compound:k242-0005|FD-Score:4.25|P-value:1.66E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:-3.70|P-value:1.52E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.19|P-value:8.97E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.52|P-value:2.88E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.65|P-value:1.79E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.31|P-value:6.20E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.46|P-value:3.59E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.60|P-value:2.17E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:-3.87|P-value:7.96E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.20|P-value:8.96E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.42|P-value:4.14E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.21|P-value:8.45E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.94|P-value:5.81E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.22|P-value:1.84E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.18|P-value:9.32E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.77|P-value:1.16E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:-3.46|P-value:3.65E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.74|P-value:1.29E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:7.97|P-value:3.47E-15 ID:SGTC_1430|Compound:4049-0248|FD-Score:5.62|P-value:2.03E-8 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.81|P-value:9.75E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.55|P-value:2.61E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.60|P-value:2.21E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.40|P-value:4.46E-4 ID:SGTC_1558|Compound:st069300|FD-Score:-4.07|P-value:3.48E-5 ID:SGTC_1571|Compound:st070080|FD-Score:3.23|P-value:7.97E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.23|P-value:8.15E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.59|P-value:2.22E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-4.48|P-value:6.10E-6 ID:SGTC_2023|Compound:5144124|FD-Score:3.35|P-value:5.23E-4 ID:SGTC_2190|Compound:6049624|FD-Score:3.20|P-value:8.83E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.73|P-value:1.35E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.20|P-value:8.74E-4 ID:SGTC_2299|Compound:7976368|FD-Score:4.92|P-value:7.61E-7 ID:SGTC_2415|Compound:st077333|FD-Score:3.34|P-value:5.44E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-3.24|P-value:7.72E-4 ID:SGTC_2848|Compound:9016370|FD-Score:4.76|P-value:1.66E-6 ID:SGTC_2933|Compound:9026794|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_3167|Compound:9103034|FD-Score:-3.48|P-value:3.42E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.43|P-value:3.97E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.50|P-value:3.16E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.77|P-value:1.17E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.80|P-value:1.02E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.68|P-value:1.64E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.63|P-value:2.99E-6 ID:SGTC_552|Compound:k242-0005|FD-Score:4.25|P-value:1.66E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:-3.70|P-value:1.52E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.19|P-value:8.97E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.52|P-value:2.88E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.65|P-value:1.79E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.31|P-value:6.20E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.46|P-value:3.59E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.60|P-value:2.17E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:-3.87|P-value:7.96E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.20|P-value:8.96E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:3.42|P-value:4.14E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.21|P-value:8.45E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.94|P-value:5.81E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.22|P-value:1.84E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.18|P-value:9.32E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.77|P-value:1.16E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:-3.46|P-value:3.65E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.74|P-value:1.29E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:7.97|P-value:3.47E-15 ID:SGTC_1430|Compound:4049-0248|FD-Score:5.62|P-value:2.03E-8 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.81|P-value:9.75E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.55|P-value:2.61E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.60|P-value:2.21E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.40|P-value:4.46E-4 ID:SGTC_1558|Compound:st069300|FD-Score:-4.07|P-value:3.48E-5 ID:SGTC_1571|Compound:st070080|FD-Score:3.23|P-value:7.97E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.23|P-value:8.15E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.59|P-value:2.22E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-4.48|P-value:6.10E-6 ID:SGTC_2023|Compound:5144124|FD-Score:3.35|P-value:5.23E-4 ID:SGTC_2190|Compound:6049624|FD-Score:3.20|P-value:8.83E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-3.73|P-value:1.35E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.20|P-value:8.74E-4 ID:SGTC_2299|Compound:7976368|FD-Score:4.92|P-value:7.61E-7 ID:SGTC_2415|Compound:st077333|FD-Score:3.34|P-value:5.44E-4 ID:SGTC_2699|Compound:st077704|FD-Score:-3.24|P-value:7.72E-4 ID:SGTC_2848|Compound:9016370|FD-Score:4.76|P-value:1.66E-6 ID:SGTC_2933|Compound:9026794|FD-Score:3.65|P-value:1.78E-4 ID:SGTC_3167|Compound:9103034|FD-Score:-3.48|P-value:3.42E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.43|P-value:3.97E-4

Top fitness defect scores for YGR250C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1408 3909-7976 7.97 48.8 µM 3.47E-15 Golgi 2 8.13E-16
2 SGTC_1430 4049-0248 5.62 69.1 µM 2.03E-8 5 9.76E-9
3 SGTC_2299 7976368 4.92 114.9 µM 7.61E-7 16 4.33E-7
4 SGTC_2848 9016370 4.76 26.0 µM 1.66E-6 10 9.76E-7
5 SGTC_142 0335-0849 4.63 62.7 µM 2.99E-6 ubiquinone biosynthesis & proteasome 99 1.81E-6
6 SGTC_552 k242-0005 4.25 476.0 µM 1.66E-5 12 1.08E-5
7 SGTC_1002 4049-0206 3.94 172.0 µM 5.81E-5 31 4.02E-5
8 SGTC_1443 4112-3303 3.81 14.0 µM 9.75E-5 8 6.90E-5
9 SGTC_644 1498-1197 3.78 63.3 µM 1.10E-4 28 7.84E-5
10 SGTC_1273 0849-0096 3.77 14.1 µM 1.16E-4 RPP1 & pyrimidine depletion 26 8.30E-5
11 SGTC_1341 1486-1360 3.74 280.0 µM 1.29E-4 31 9.23E-5
12 SGTC_135 0933-0004 3.68 26.4 µM 1.64E-4 60S ribosome export 31 1.19E-4
13 SGTC_2933 9026794 3.65 32.5 µM 1.78E-4 31 1.29E-4
14 SGTC_655 k060-0012 3.65 42.0 µM 1.79E-4 22 1.30E-4
15 SGTC_780 0109-0199 3.60 192.0 µM 2.17E-4 24 1.59E-4
16 SGTC_1924 st058459 3.59 75.1 µM 2.22E-4 17 1.63E-4
17 SGTC_1542 7-hydroxy-3'-methoxyflavone 3.55 49.7 µM 2.61E-4 22 1.93E-4
18 SGTC_558 k064-0027 3.52 21.3 µM 2.88E-4 DNA damage response 37 2.13E-4
19 SGTC_756 0508-1999 3.46 28.3 µM 3.59E-4 RPP1 & pyrimidine depletion 46 2.69E-4
20 SGTC_899 1083-0020 3.42 478.0 µM 4.14E-4 39 3.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 9.15E-10 YCR067C SED4 hom Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p
0.094 5.55E-8 YIR016W_p YIR016W_p hom Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication
0.093 6.14E-8 YPL177C CUP9 hom Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.086 5.54E-7 YGR256W GND2 hom 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication
0.080 3.41E-6 YPL258C THI21 hom Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
0.079 4.39E-6 YGL018C JAC1 het Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
0.076 9.95E-6 YHR106W TRR2 hom Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication
0.072 3.09E-5 YJL010C NOP9 het Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain
0.071 3.56E-5 YKL071W_p YKL071W_p hom Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.070 4.63E-5 YKL050C YKL050C hom Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p
0.067 1.08E-4 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.067 1.12E-4 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.066 1.48E-4 YLL006W-A_p YLL006W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.065 1.86E-4 YMR078C CTF18 hom Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
0.063 2.58E-4 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase