HIPHOP chemogenomics database

YGR270W / YTA7

Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR270W / YTA7

Click on Significant Values for Screen Details

Top fitness defect scores for YGR270W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1788	fluconazole	8.75	20.0 µM	1.62E-13	azole & statin	15	1.06E-18
2	SGTC_1	0258-0098	8.43	57.4 µM	1.11E-12	heme biosynthesis & mitochondrial translocase	1	1.66E-17
3	SGTC_1310	1188-0297	7.71	994.0 nM	7.18E-11	azole & statin	4	6.47E-15
4	SGTC_2364	9055074	6.21	200.0 µM	1.23E-7		5	2.70E-10
5	SGTC_141	0443-0274	5.95	32.3 µM	3.87E-7	mitochondrial response to ROS	17	1.38E-9
6	SGTC_383	2324-0395	5.75	7.4 µM	8.71E-7	azole & statin	17	4.38E-9
7	SGTC_682	0kpi-0099	5.55	17.0 µM	2.03E-6		28	1.46E-8
8	SGTC_1347	1493-0251	5.54	600.0 nM	2.07E-6	mitochondrial response to ROS	4	1.51E-8
9	SGTC_210	3551-0445	5.49	56.8 µM	2.51E-6		31	1.98E-8
10	SGTC_221	trifluoperazine	5.47	10.3 µM	2.78E-6	NEO1-PIK1	145	2.29E-8
11	SGTC_116	0155-0182	5.33	31.8 µM	4.68E-6	mitochondrial response to ROS	35	4.80E-8
12	SGTC_299	1273-0059	5.11	1.4 µM	1.11E-5		13	1.64E-7
13	SGTC_778	3456-2434	4.96	196.0 µM	1.93E-5	mitochondrial response to ROS	47	3.61E-7
14	SGTC_258	haloperidol	4.65	50.8 µM	5.58E-5	fatty acid desaturase (OLE1)	18	1.62E-6
15	SGTC_1803	st050068	4.64	52.4 µM	5.95E-5	NEO1-PIK1	133	1.78E-6
16	SGTC_379	3970-0972	4.57	5.9 µM	7.37E-5	tubulin folding & SWR complex	18	2.41E-6
17	SGTC_1800	st050079	4.42	29.1 µM	1.24E-4	NEO1-PIK1	101	5.02E-6
18	SGTC_3304	9125678	4.31	46.1 µM	1.77E-4		36	8.32E-6
19	SGTC_1317	1273-0028	4.24	910.0 nM	2.20E-4	azole & statin	43	1.14E-5
20	SGTC_394	menadione	4.18	8.3 µM	2.60E-4	superoxide	24	1.44E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.224	2.94E-39	YGR122W	YGR122W	hom	Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.217	3.30E-37	YPL170W	DAP1	hom	Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
0.216	9.18E-37	YMR154C	RIM13	hom	Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.216	1.01E-36	YHR045W_p	YHR045W_p	hom	Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.213	6.93E-36	YNL294C	RIM21	hom	pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.197	1.14E-30	YML037C_p	YML037C_p	hom	Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.186	1.86E-27	YOR275C	RIM20	hom	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.182	2.29E-26	YMR063W	RIM9	hom	Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.173	6.43E-24	YCR094W	CDC50	hom	Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.169	9.00E-23	YGL045W	RIM8	hom	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.163	2.34E-21	YHL027W	RIM101	hom	Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.159	2.07E-20	YDR334W	SWR1	hom	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.156	7.81E-20	YLR020C	YEH2	hom	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.156	9.83E-20	YOR115C	TRS33	hom	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.156	1.00E-19	YLR025W	SNF7	hom	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes