YGR286C / BIO2

Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR286C / BIO2

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.59|P-value:1.15E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:-3.56|P-value:1.60E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.61|P-value:1.14E-6 ID:SGTC_296|Compound:1222-0039|FD-Score:4.18|P-value:8.99E-6 ID:SGTC_404|Compound:fumagillin|FD-Score:3.44|P-value:2.05E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.75|P-value:5.91E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:-4.17|P-value:1.24E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.47|P-value:2.30E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.00|P-value:2.08E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.90|P-value:3.22E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:6.80|P-value:1.82E-12 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.63|P-value:1.25E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.45|P-value:1.99E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.23|P-value:4.62E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.14|P-value:6.38E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.92|P-value:2.93E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.64|P-value:9.50E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.41|P-value:2.30E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.14|P-value:6.24E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.66|P-value:8.81E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.79|P-value:5.13E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.59|P-value:1.15E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.40|P-value:2.43E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.48|P-value:1.79E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.37|P-value:2.72E-4 ID:SGTC_1721|Compound:st082152|FD-Score:4.12|P-value:1.23E-5 ID:SGTC_1733|Compound:st037357|FD-Score:4.19|P-value:8.64E-6 ID:SGTC_1748|Compound:st037455|FD-Score:3.80|P-value:4.77E-5 ID:SGTC_1771|Compound:st048882|FD-Score:3.14|P-value:6.27E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.08|P-value:7.79E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.04|P-value:8.79E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.17|P-value:5.60E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.39|P-value:2.46E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.33|P-value:3.12E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-3.40|P-value:3.01E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.21|P-value:7.87E-6 ID:SGTC_1991|Compound:st073000|FD-Score:3.49|P-value:1.68E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.41|P-value:2.33E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.02|P-value:9.49E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.89|P-value:3.79E-7 ID:SGTC_2309|Compound:7664088|FD-Score:4.51|P-value:1.95E-6 ID:SGTC_2364|Compound:9055074|FD-Score:-3.56|P-value:1.61E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.40|P-value:2.40E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-5.84|P-value:1.62E-9 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.61|P-value:1.05E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.24|P-value:5.48E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.24|P-value:4.43E-4 ID:SGTC_2698|Compound:st077697|FD-Score:5.72|P-value:2.46E-9 ID:SGTC_2707|Compound:st078556|FD-Score:3.11|P-value:6.95E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.03|P-value:9.25E-4 ID:SGTC_2847|Compound:9005661|FD-Score:4.87|P-value:3.14E-7 ID:SGTC_2887|Compound:9044784|FD-Score:3.47|P-value:1.83E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-4.02|P-value:2.38E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-3.60|P-value:1.41E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.06|P-value:8.28E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.50|P-value:1.65E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.47|P-value:1.88E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.59|P-value:1.15E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:-3.56|P-value:1.60E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.61|P-value:1.14E-6 ID:SGTC_296|Compound:1222-0039|FD-Score:4.18|P-value:8.99E-6 ID:SGTC_404|Compound:fumagillin|FD-Score:3.44|P-value:2.05E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.75|P-value:5.91E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:-4.17|P-value:1.24E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:-3.47|P-value:2.30E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.00|P-value:2.08E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.90|P-value:3.22E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:6.80|P-value:1.82E-12 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.63|P-value:1.25E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.45|P-value:1.99E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.23|P-value:4.62E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.14|P-value:6.38E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.92|P-value:2.93E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.64|P-value:9.50E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.41|P-value:2.30E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.14|P-value:6.24E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.66|P-value:8.81E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.79|P-value:5.13E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.59|P-value:1.15E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:3.40|P-value:2.43E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.48|P-value:1.79E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.37|P-value:2.72E-4 ID:SGTC_1721|Compound:st082152|FD-Score:4.12|P-value:1.23E-5 ID:SGTC_1733|Compound:st037357|FD-Score:4.19|P-value:8.64E-6 ID:SGTC_1748|Compound:st037455|FD-Score:3.80|P-value:4.77E-5 ID:SGTC_1771|Compound:st048882|FD-Score:3.14|P-value:6.27E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.08|P-value:7.79E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.04|P-value:8.79E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.17|P-value:5.60E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.39|P-value:2.46E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.33|P-value:3.12E-4 ID:SGTC_1981|Compound:st071826|FD-Score:-3.40|P-value:3.01E-4 ID:SGTC_1982|Compound:st072467|FD-Score:4.21|P-value:7.87E-6 ID:SGTC_1991|Compound:st073000|FD-Score:3.49|P-value:1.68E-4 ID:SGTC_2057|Compound:5236571|FD-Score:3.41|P-value:2.33E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.02|P-value:9.49E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.89|P-value:3.79E-7 ID:SGTC_2309|Compound:7664088|FD-Score:4.51|P-value:1.95E-6 ID:SGTC_2364|Compound:9055074|FD-Score:-3.56|P-value:1.61E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.40|P-value:2.40E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-5.84|P-value:1.62E-9 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.61|P-value:1.05E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.24|P-value:5.48E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.24|P-value:4.43E-4 ID:SGTC_2698|Compound:st077697|FD-Score:5.72|P-value:2.46E-9 ID:SGTC_2707|Compound:st078556|FD-Score:3.11|P-value:6.95E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.03|P-value:9.25E-4 ID:SGTC_2847|Compound:9005661|FD-Score:4.87|P-value:3.14E-7 ID:SGTC_2887|Compound:9044784|FD-Score:3.47|P-value:1.83E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-4.02|P-value:2.38E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-3.60|P-value:1.41E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.06|P-value:8.28E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.50|P-value:1.65E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.47|P-value:1.88E-4

Top fitness defect scores for YGR286C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_776 4476-4378 6.80 112.0 µM 1.82E-12 ERG2 5 5.26E-12
2 SGTC_2698 st077697 5.72 67.5 µM 2.46E-9 5 5.39E-9
3 SGTC_2847 9005661 4.87 71.4 µM 3.14E-7 5 5.70E-7
4 SGTC_20 0481-0013 4.61 4.9 µM 1.14E-6 13 1.97E-6
5 SGTC_2309 7664088 4.51 163.9 µM 1.95E-6 17 3.30E-6
6 SGTC_1982 st072467 4.21 71.9 µM 7.87E-6 31 1.26E-5
7 SGTC_1733 st037357 4.19 54.9 µM 8.64E-6 60S ribosome export 19 1.38E-5
8 SGTC_296 1222-0039 4.18 74.9 µM 8.99E-6 10 1.43E-5
9 SGTC_1721 st082152 4.12 9.3 µM 1.23E-5 60S ribosome export 17 1.93E-5
10 SGTC_604 1000-0114 4.00 314.0 µM 2.08E-5 19 3.19E-5
11 SGTC_1068 loratadine 3.92 26.9 µM 2.93E-5 23 4.45E-5
12 SGTC_685 1278-0033 3.90 54.9 µM 3.22E-5 60S ribosome export 23 4.86E-5
13 SGTC_1748 st037455 3.80 53.6 µM 4.77E-5 36 7.10E-5
14 SGTC_1267 0828-0272 3.79 9.5 µM 5.13E-5 23 7.62E-5
15 SGTC_512 prima-1 3.75 270.0 µM 5.91E-5 DNA intercalators 29 8.73E-5
16 SGTC_1264 0783-0040 3.66 158.0 µM 8.81E-5 37 1.28E-4
17 SGTC_1169 aniline yellow 3.64 25.8 µM 9.50E-5 19 1.38E-4
18 SGTC_2604 4'-hydroxychalcone 3.61 11.3 µM 1.05E-4 51 1.52E-4
19 SGTC_1327 1436-0082 3.59 2.2 µM 1.15E-4 30 1.65E-4
20 SGTC_4 0960-0234 3.59 25.7 µM 1.15E-4 Golgi 17 1.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 9.68E-12 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.113 6.53E-11 YNR075W COS10 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.106 8.20E-10 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.100 7.30E-9 YDR236C FMN1 het Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
0.091 1.24E-7 YLR406C-A_p YLR406C-A_p hom Putative protein of unknown function
0.086 5.40E-7 YDR327W_d YDR327W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1
0.082 2.04E-6 YNL034W_p YNL034W_p hom Putative protein of unknown function; YNL034W is not an essential gene
0.078 5.94E-6 YBR028C YPK3 hom An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner
0.073 2.13E-5 YML054C-A_p YML054C-A_p hom Putative protein of unknown function
0.069 6.67E-5 YLL047W_d YLL047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
0.067 1.07E-4 YIL149C MLP2 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
0.067 1.16E-4 YGR094W VAS1 het Mitochondrial and cytoplasmic valyl-tRNA synthetase
0.066 1.28E-4 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
0.064 1.90E-4 YJR011C_p YJR011C_p hom Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
0.064 1.96E-4 YCR072C RSA4 het WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus