YHL015W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL015W-A / YHL015W-A

Click on Significant Values for Screen Details ID:SGTC_311|Compound:1315-0136|FD-Score:4.35|P-value:2.97E-6 ID:SGTC_334|Compound:1502-1024|FD-Score:4.10|P-value:9.86E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:4.30|P-value:3.71E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:3.04|P-value:7.72E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.20|P-value:5.01E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.05|P-value:7.31E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:-4.68|P-value:7.17E-7 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.08|P-value:7.72E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.20|P-value:4.29E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.73|P-value:5.14E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.21|P-value:4.80E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.21|P-value:5.77E-6 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.45|P-value:1.59E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.45|P-value:1.79E-6 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.15|P-value:5.06E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.60|P-value:8.75E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.27|P-value:2.16E-8 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.68|P-value:7.48E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.17|P-value:4.72E-4 ID:SGTC_1832|Compound:st054113|FD-Score:2.98|P-value:9.30E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.96|P-value:1.85E-5 ID:SGTC_1927|Compound:st060202|FD-Score:-3.92|P-value:2.73E-5 ID:SGTC_1936|Compound:st074407|FD-Score:3.56|P-value:1.04E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.11|P-value:6.94E-4 ID:SGTC_2219|Compound:9098279|FD-Score:2.97|P-value:9.74E-4 ID:SGTC_2242|Compound:6630449|FD-Score:2.97|P-value:9.59E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.08|P-value:7.83E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.08|P-value:1.07E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.25|P-value:4.87E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.91|P-value:2.37E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.11|P-value:1.15E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:5.00|P-value:1.02E-7 ID:SGTC_2691|Compound:st077356|FD-Score:-3.56|P-value:1.22E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.19|P-value:4.45E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.78|P-value:4.89E-5 ID:SGTC_2824|Compound:7998404|FD-Score:3.00|P-value:8.81E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.22|P-value:3.95E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.53|P-value:1.18E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.26|P-value:3.98E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-3.27|P-value:3.91E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.37|P-value:2.74E-6 ID:SGTC_3103|Compound:9120822|FD-Score:3.27|P-value:3.30E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.97|P-value:1.15E-7 ID:SGTC_3284|Compound:9108171|FD-Score:-3.19|P-value:5.24E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.56|P-value:1.25E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:4.35|P-value:2.97E-6 ID:SGTC_334|Compound:1502-1024|FD-Score:4.10|P-value:9.86E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:4.30|P-value:3.71E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:3.04|P-value:7.72E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.20|P-value:5.01E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.05|P-value:7.31E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:-4.68|P-value:7.17E-7 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.08|P-value:7.72E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.20|P-value:4.29E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.73|P-value:5.14E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.21|P-value:4.80E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.21|P-value:5.77E-6 ID:SGTC_1458|Compound:k015-0034|FD-Score:3.45|P-value:1.59E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:4.45|P-value:1.79E-6 ID:SGTC_1485|Compound:3909-9022|FD-Score:3.15|P-value:5.06E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.60|P-value:8.75E-5 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:5.27|P-value:2.16E-8 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.68|P-value:7.48E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.17|P-value:4.72E-4 ID:SGTC_1832|Compound:st054113|FD-Score:2.98|P-value:9.30E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.96|P-value:1.85E-5 ID:SGTC_1927|Compound:st060202|FD-Score:-3.92|P-value:2.73E-5 ID:SGTC_1936|Compound:st074407|FD-Score:3.56|P-value:1.04E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.11|P-value:6.94E-4 ID:SGTC_2219|Compound:9098279|FD-Score:2.97|P-value:9.74E-4 ID:SGTC_2242|Compound:6630449|FD-Score:2.97|P-value:9.59E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.08|P-value:7.83E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.08|P-value:1.07E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.25|P-value:4.87E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.91|P-value:2.37E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.11|P-value:1.15E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:5.00|P-value:1.02E-7 ID:SGTC_2691|Compound:st077356|FD-Score:-3.56|P-value:1.22E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.19|P-value:4.45E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.78|P-value:4.89E-5 ID:SGTC_2824|Compound:7998404|FD-Score:3.00|P-value:8.81E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.22|P-value:3.95E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.53|P-value:1.18E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.26|P-value:3.98E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-3.27|P-value:3.91E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.37|P-value:2.74E-6 ID:SGTC_3103|Compound:9120822|FD-Score:3.27|P-value:3.30E-4 ID:SGTC_3137|Compound:9097352|FD-Score:4.97|P-value:1.15E-7 ID:SGTC_3284|Compound:9108171|FD-Score:-3.19|P-value:5.24E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.56|P-value:1.25E-4

Top fitness defect scores for YHL015W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1528 arabinosylhypoxanthine 5.27 74.6 µM 2.16E-8 8 6.93E-8
2 SGTC_2606 farnesol 5.00 9.8 µM 1.02E-7 8 2.93E-7
3 SGTC_3137 9097352 4.97 49.5 µM 1.15E-7 17 3.28E-7
4 SGTC_1481 3346-2004 4.45 36.0 µM 1.79E-6 4 4.23E-6
5 SGTC_2971 9092186 4.37 9.9 µM 2.74E-6 ergosterol biosynthesis 20 6.29E-6
6 SGTC_311 1315-0136 4.35 58.0 µM 2.97E-6 6 6.79E-6
7 SGTC_360 0957-0399 4.30 1.0 µM 3.71E-6 cell wall 35 8.35E-6
8 SGTC_2580 diallyl disulphide 4.25 81.4 µM 4.87E-6 17 1.08E-5
9 SGTC_1259 0671-0132 4.21 43.0 µM 5.77E-6 20 1.26E-5
10 SGTC_334 1502-1024 4.10 68.5 µM 9.86E-6 10 2.07E-5
11 SGTC_2450 5739737 4.08 12.9 µM 1.07E-5 23 2.23E-5
12 SGTC_1921 5740136 3.96 50.0 µM 1.85E-5 TRP & mitochondrial translation 59 3.72E-5
13 SGTC_2586 curcumin 3.91 80.0 µM 2.37E-5 iron homeostasis 52 4.69E-5
14 SGTC_1133 3473-0247 3.73 50.0 µM 5.14E-5 RSC complex & mRNA processing 59 9.63E-5
15 SGTC_1503 4585-0012 3.60 61.3 µM 8.75E-5 26 1.58E-4
16 SGTC_1936 st074407 3.56 74.3 µM 1.04E-4 DNA damage response 52 1.86E-4
17 SGTC_2849 9019321 3.53 13.0 µM 1.18E-4 44 2.10E-4
18 SGTC_1458 k015-0034 3.45 6.3 µM 1.59E-4 22 2.75E-4
19 SGTC_3103 9120822 3.27 49.5 µM 3.30E-4 37 5.44E-4
20 SGTC_2848 9016370 3.22 26.0 µM 3.95E-4 59 6.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 6.00E-12 YBR131W CCZ1 hom Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
0.088 3.27E-7 YKL040C NFU1 hom Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
0.085 9.57E-7 YJR078W BNA2 hom Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp
0.084 1.03E-6 YCL037C SRO9 hom Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication
0.084 1.27E-6 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
0.083 1.38E-6 YGR087C PDC6 hom Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
0.083 1.58E-6 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.082 1.85E-6 YDL179W PCL9 hom Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
0.082 2.15E-6 YHR077C NMD2 hom Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
0.080 3.67E-6 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.079 4.70E-6 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.079 5.35E-6 YAR002W NUP60 hom FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153
0.077 7.23E-6 YJL098W SAP185 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication
0.077 7.54E-6 YLR032W RAD5 hom DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress
0.076 1.01E-5 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress