YHL016C / DUR3

Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL016C / DUR3

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:-3.83|P-value:2.00E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:3.13|P-value:3.32E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-4.05|P-value:6.79E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:3.45|P-value:9.01E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:-4.85|P-value:9.43E-8 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.91|P-value:1.38E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.53|P-value:7.54E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:3.43|P-value:9.63E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:3.19|P-value:2.64E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-2.97|P-value:7.32E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.93|P-value:8.59E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.08|P-value:5.87E-6 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.08|P-value:4.10E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.87|P-value:1.38E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.35|P-value:1.40E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.34|P-value:3.58E-9 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.54|P-value:6.23E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.19|P-value:3.34E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.98|P-value:9.86E-6 ID:SGTC_1490|Compound:4089-0339|FD-Score:2.91|P-value:7.96E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.31|P-value:1.63E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.08|P-value:4.03E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-2.90|P-value:9.41E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.55|P-value:5.95E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.40|P-value:1.13E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-3.30|P-value:2.01E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.37|P-value:1.25E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.12|P-value:3.45E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.41|P-value:1.06E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.29|P-value:1.61E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-4.12|P-value:4.73E-6 ID:SGTC_2002|Compound:4023503|FD-Score:3.06|P-value:4.39E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.41|P-value:1.08E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.45|P-value:9.01E-5 ID:SGTC_2399|Compound:5884133|FD-Score:2.88|P-value:8.79E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.09|P-value:3.88E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.91|P-value:1.12E-5 ID:SGTC_2696|Compound:st077691|FD-Score:3.29|P-value:1.76E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.10|P-value:4.42E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.41|P-value:1.25E-4 ID:SGTC_3201|Compound:9113999|FD-Score:15.10|P-value:1.60E-60 ID:SGTC_3204|Compound:9114183|FD-Score:6.18|P-value:1.09E-11 ID:SGTC_3206|Compound:9114350|FD-Score:-11.40|P-value:7.10E-35 ID:SGTC_3209|Compound:9113616|FD-Score:-5.32|P-value:5.22E-9 ID:SGTC_3339|Compound:9145883|FD-Score:3.39|P-value:1.19E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.83|P-value:2.00E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:3.13|P-value:3.32E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-4.05|P-value:6.79E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:3.45|P-value:9.01E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:-4.85|P-value:9.43E-8 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.91|P-value:1.38E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.53|P-value:7.54E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:3.43|P-value:9.63E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:3.19|P-value:2.64E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-2.97|P-value:7.32E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-2.93|P-value:8.59E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.08|P-value:5.87E-6 ID:SGTC_1142|Compound:3253-1408|FD-Score:3.08|P-value:4.10E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.87|P-value:1.38E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.35|P-value:1.40E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:5.34|P-value:3.58E-9 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.54|P-value:6.23E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.19|P-value:3.34E-6 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.98|P-value:9.86E-6 ID:SGTC_1490|Compound:4089-0339|FD-Score:2.91|P-value:7.96E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.31|P-value:1.63E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.08|P-value:4.03E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-2.90|P-value:9.41E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.55|P-value:5.95E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.40|P-value:1.13E-4 ID:SGTC_1779|Compound:st039427|FD-Score:-3.30|P-value:2.01E-4 ID:SGTC_1790|Compound:st045711|FD-Score:3.37|P-value:1.25E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.12|P-value:3.45E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.41|P-value:1.06E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.29|P-value:1.61E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-4.12|P-value:4.73E-6 ID:SGTC_2002|Compound:4023503|FD-Score:3.06|P-value:4.39E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.41|P-value:1.08E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.45|P-value:9.01E-5 ID:SGTC_2399|Compound:5884133|FD-Score:2.88|P-value:8.79E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.09|P-value:3.88E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.91|P-value:1.12E-5 ID:SGTC_2696|Compound:st077691|FD-Score:3.29|P-value:1.76E-4 ID:SGTC_2802|Compound:7925815|FD-Score:-3.10|P-value:4.42E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.41|P-value:1.25E-4 ID:SGTC_3201|Compound:9113999|FD-Score:15.10|P-value:1.60E-60 ID:SGTC_3204|Compound:9114183|FD-Score:6.18|P-value:1.09E-11 ID:SGTC_3206|Compound:9114350|FD-Score:-11.40|P-value:7.10E-35 ID:SGTC_3209|Compound:9113616|FD-Score:-5.32|P-value:5.22E-9 ID:SGTC_3339|Compound:9145883|FD-Score:3.39|P-value:1.19E-4

Top fitness defect scores for YHL016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3201 9113999 15.10 49.5 µM 1.60E-60 1 3.84E-52
2 SGTC_3204 9114183 6.18 49.5 µM 1.09E-11 8 3.16E-10
3 SGTC_1248 0469-0687 5.34 58.6 µM 3.58E-9 6 4.58E-8
4 SGTC_1948 st076329 4.29 66.6 µM 1.61E-6 19 8.75E-6
5 SGTC_2483 5729050 3.91 27.2 µM 1.12E-5 25 4.66E-5
6 SGTC_1153 4055-0057 3.87 267.0 µM 1.38E-5 28 5.55E-5
7 SGTC_1719 st032227 3.55 49.2 µM 5.95E-5 34 1.96E-4
8 SGTC_1252 0493-0875 3.54 34.8 µM 6.23E-5 42 2.04E-4
9 SGTC_2301 7769476 3.45 200.0 µM 9.01E-5 30 2.80E-4
10 SGTC_348 k064-0012 3.45 10.7 µM 9.01E-5 60S ribosome export 28 2.80E-4
11 SGTC_702 1488-0190 3.43 94.0 µM 9.63E-5 amide catabolism 27 2.96E-4
12 SGTC_1946 st076057 3.41 65.1 µM 1.06E-4 14 3.21E-4
13 SGTC_2116 5511452 3.41 16.9 µM 1.08E-4 32 3.27E-4
14 SGTC_1728 st035614 3.40 33.8 µM 1.13E-4 83 3.39E-4
15 SGTC_3339 9145883 3.39 14.9 µM 1.19E-4 27 3.55E-4
16 SGTC_1790 st045711 3.37 43.5 µM 1.25E-4 27 3.72E-4
17 SGTC_1170 0310-0127 3.35 64.8 µM 1.40E-4 46 4.10E-4
18 SGTC_1500 4488-1866 3.31 171.0 µM 1.63E-4 RPP1 & pyrimidine depletion 41 4.68E-4
19 SGTC_2696 st077691 3.29 74.3 µM 1.76E-4 55 5.00E-4
20 SGTC_929 2805-0021 3.19 398.0 µM 2.64E-4 37 7.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.02E-24 YPR108W-A_p YPR108W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.168 1.21E-22 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.166 4.89E-22 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.160 1.20E-20 YBR115C LYS2 hom Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
0.159 1.83E-20 YJR002W MPP10 het Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
0.147 1.29E-17 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.133 8.72E-15 YDL031W DBP10 het Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
0.133 1.28E-14 YDR221W GTB1 hom Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress
0.130 4.41E-14 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.125 4.30E-13 YLR221C RSA3 hom Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
0.122 1.52E-12 YOL075C_p YOL075C_p hom Putative ABC transporter
0.121 2.06E-12 YDR061W_p YDR061W_p hom Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
0.119 4.15E-12 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein
0.117 8.56E-12 YDR275W BSC2 hom Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication
0.112 8.15E-11 YLR177W_p YLR177W_p hom Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication