YHL017W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL017W / YHL017W

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:2.85|P-value:8.47E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-4.37|P-value:7.45E-7 ID:SGTC_203|Compound:k066-0004|FD-Score:-2.91|P-value:6.80E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.37|P-value:1.06E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.45|P-value:7.31E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.99|P-value:5.48E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.19|P-value:2.23E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:2.89|P-value:7.53E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-2.93|P-value:6.18E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:4.67|P-value:1.36E-7 ID:SGTC_939|Compound:1165-0479|FD-Score:2.89|P-value:7.52E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.04|P-value:4.08E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.42|P-value:8.36E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.31|P-value:1.35E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-2.92|P-value:6.56E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.19|P-value:2.22E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.18|P-value:2.31E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:-2.86|P-value:8.19E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.57|P-value:4.22E-5 ID:SGTC_1815|Compound:st051655|FD-Score:2.89|P-value:7.39E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.31|P-value:1.37E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.00|P-value:4.72E-4 ID:SGTC_1935|Compound:st074532|FD-Score:5.21|P-value:5.05E-9 ID:SGTC_1939|Compound:st074455|FD-Score:3.63|P-value:3.23E-5 ID:SGTC_1984|Compound:st072354|FD-Score:3.44|P-value:7.79E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.84|P-value:1.18E-5 ID:SGTC_1995|Compound:st072814|FD-Score:2.93|P-value:6.41E-4 ID:SGTC_1997|Compound:st073024|FD-Score:4.48|P-value:4.20E-7 ID:SGTC_2070|Compound:5230947|FD-Score:-4.82|P-value:5.71E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.78|P-value:1.60E-5 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.26|P-value:1.70E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.19|P-value:1.98E-6 ID:SGTC_2303|Compound:7774051|FD-Score:-3.28|P-value:1.52E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.18|P-value:2.30E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.51|P-value:5.63E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-3.02|P-value:4.49E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.02|P-value:4.86E-6 ID:SGTC_2436|Compound:5633522|FD-Score:4.49|P-value:3.93E-7 ID:SGTC_2479|Compound:5617353|FD-Score:3.57|P-value:4.27E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.32|P-value:1.28E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.22|P-value:1.69E-6 ID:SGTC_2782|Compound:7736369|FD-Score:5.30|P-value:2.72E-9 ID:SGTC_2785|Compound:7756463|FD-Score:-5.87|P-value:5.08E-11 ID:SGTC_2789|Compound:5281112|FD-Score:-3.38|P-value:9.93E-5 ID:SGTC_2798|Compound:7813637|FD-Score:4.62|P-value:1.81E-7 ID:SGTC_2838|Compound:9002687|FD-Score:-3.15|P-value:2.62E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.08|P-value:3.43E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.47|P-value:6.84E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:2.85|P-value:8.47E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-4.37|P-value:7.45E-7 ID:SGTC_203|Compound:k066-0004|FD-Score:-2.91|P-value:6.80E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.37|P-value:1.06E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.45|P-value:7.31E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.99|P-value:5.48E-6 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.19|P-value:2.23E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:2.89|P-value:7.53E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-2.93|P-value:6.18E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:4.67|P-value:1.36E-7 ID:SGTC_939|Compound:1165-0479|FD-Score:2.89|P-value:7.52E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.04|P-value:4.08E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.42|P-value:8.36E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.31|P-value:1.35E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-2.92|P-value:6.56E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.19|P-value:2.22E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.18|P-value:2.31E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:-2.86|P-value:8.19E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.57|P-value:4.22E-5 ID:SGTC_1815|Compound:st051655|FD-Score:2.89|P-value:7.39E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.31|P-value:1.37E-4 ID:SGTC_1901|Compound:st060216|FD-Score:-3.00|P-value:4.72E-4 ID:SGTC_1935|Compound:st074532|FD-Score:5.21|P-value:5.05E-9 ID:SGTC_1939|Compound:st074455|FD-Score:3.63|P-value:3.23E-5 ID:SGTC_1984|Compound:st072354|FD-Score:3.44|P-value:7.79E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.84|P-value:1.18E-5 ID:SGTC_1995|Compound:st072814|FD-Score:2.93|P-value:6.41E-4 ID:SGTC_1997|Compound:st073024|FD-Score:4.48|P-value:4.20E-7 ID:SGTC_2070|Compound:5230947|FD-Score:-4.82|P-value:5.71E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.78|P-value:1.60E-5 ID:SGTC_2252|Compound:omeprazole|FD-Score:3.26|P-value:1.70E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.19|P-value:1.98E-6 ID:SGTC_2303|Compound:7774051|FD-Score:-3.28|P-value:1.52E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.18|P-value:2.30E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.51|P-value:5.63E-5 ID:SGTC_2364|Compound:9055074|FD-Score:-3.02|P-value:4.49E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.02|P-value:4.86E-6 ID:SGTC_2436|Compound:5633522|FD-Score:4.49|P-value:3.93E-7 ID:SGTC_2479|Compound:5617353|FD-Score:3.57|P-value:4.27E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.32|P-value:1.28E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.22|P-value:1.69E-6 ID:SGTC_2782|Compound:7736369|FD-Score:5.30|P-value:2.72E-9 ID:SGTC_2785|Compound:7756463|FD-Score:-5.87|P-value:5.08E-11 ID:SGTC_2789|Compound:5281112|FD-Score:-3.38|P-value:9.93E-5 ID:SGTC_2798|Compound:7813637|FD-Score:4.62|P-value:1.81E-7 ID:SGTC_2838|Compound:9002687|FD-Score:-3.15|P-value:2.62E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.08|P-value:3.43E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.47|P-value:6.84E-5

Top fitness defect scores for YHL017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2782 7736369 5.30 71.4 µM 2.72E-9 14 5.74E-8
2 SGTC_1935 st074532 5.21 41.6 µM 5.05E-9 7 9.59E-8
3 SGTC_910 3454-3003 4.67 490.0 µM 1.36E-7 6 1.48E-6
4 SGTC_2798 7813637 4.62 45.5 µM 1.81E-7 18 1.87E-6
5 SGTC_2436 5633522 4.49 8.1 µM 3.93E-7 10 3.58E-6
6 SGTC_1997 st073024 4.48 93.8 µM 4.20E-7 4 3.78E-6
7 SGTC_2753 fluvastatin 4.22 17.1 µM 1.69E-6 azole & statin 28 1.20E-5
8 SGTC_2259 7964009 4.19 200.0 µM 1.98E-6 superoxide 24 1.37E-5
9 SGTC_1991 st073000 3.84 8.9 µM 1.18E-5 NEO1 83 6.08E-5
10 SGTC_1939 st074455 3.63 53.6 µM 3.23E-5 37 1.41E-4
11 SGTC_1490 4089-0339 3.57 670.0 nM 4.22E-5 14 1.76E-4
12 SGTC_2479 5617353 3.57 43.9 µM 4.27E-5 54 1.78E-4
13 SGTC_2357 9067248 3.51 200.0 µM 5.63E-5 34 2.24E-4
14 SGTC_2908 7930301 3.47 100.0 µM 6.84E-5 45 2.63E-4
15 SGTC_780 0109-0199 3.45 192.0 µM 7.31E-5 35 2.78E-4
16 SGTC_1984 st072354 3.44 53.1 µM 7.79E-5 25 2.94E-4
17 SGTC_1059 3448-6867 3.42 171.0 µM 8.36E-5 23 3.11E-4
18 SGTC_430 0958-0115 3.37 16.4 µM 1.06E-4 55 3.79E-4
19 SGTC_2553 4-methylesculetin 3.32 85.1 µM 1.28E-4 46 4.43E-4
20 SGTC_1061 3448-9325 3.31 110.0 µM 1.35E-4 39 4.64E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.52E-13 YDR036C EHD3 hom 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
0.102 2.96E-9 YMR272C SCS7 hom Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
0.097 2.12E-8 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.093 6.43E-8 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.091 1.24E-7 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.091 1.50E-7 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.084 1.05E-6 YHR134W WSS1 hom Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response
0.084 1.22E-6 YBR128C ATG14 hom Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor
0.082 2.18E-6 YCL033C MXR2 hom Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan
0.081 2.66E-6 YOR106W VAM3 hom Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region
0.081 2.81E-6 YBR089C-A NHP6B hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication
0.078 6.72E-6 YNL336W COS1 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.077 7.30E-6 YBL071C-B_p YBL071C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.077 7.38E-6 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.075 1.36E-5 YGR225W AMA1 hom Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis