YHL025W / SNF6

Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL025W / SNF6

Click on Significant Values for Screen Details ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:-4.33|P-value:3.66E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.47|P-value:1.57E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.13|P-value:5.70E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.20|P-value:4.27E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.25|P-value:3.60E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-5.40|P-value:1.23E-8 ID:SGTC_373|Compound:0844-0104|FD-Score:-3.83|P-value:3.57E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-4.96|P-value:1.48E-7 ID:SGTC_531|Compound:3788-1495|FD-Score:-5.85|P-value:7.76E-10 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.45|P-value:1.69E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:-3.13|P-value:5.65E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-4.35|P-value:3.28E-6 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.60|P-value:9.19E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.93|P-value:2.29E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:-5.36|P-value:1.56E-8 ID:SGTC_811|Compound:0416-0114|FD-Score:-5.54|P-value:5.12E-9 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.23|P-value:3.94E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.65|P-value:7.51E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.96|P-value:2.00E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-9.51|P-value:6.70E-23 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.40|P-value:2.62E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-5.47|P-value:8.16E-9 ID:SGTC_921|Compound:1561-0023|FD-Score:-5.27|P-value:2.60E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.11|P-value:5.99E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.30|P-value:2.97E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.17|P-value:4.90E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-8.81|P-value:5.99E-20 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.65|P-value:7.41E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.01|P-value:8.42E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:-2.99|P-value:9.27E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.50|P-value:1.37E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-5.55|P-value:4.85E-9 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.02|P-value:8.20E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:-4.20|P-value:6.73E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:-11.80|P-value:4.06E-34 ID:SGTC_1131|Compound:3454-3128|FD-Score:-13.40|P-value:1.05E-43 ID:SGTC_1132|Compound:3456-3614|FD-Score:-7.92|P-value:1.65E-16 ID:SGTC_1138|Compound:3761-0006|FD-Score:-5.28|P-value:2.38E-8 ID:SGTC_1139|Compound:k015-0024|FD-Score:-4.60|P-value:9.35E-7 ID:SGTC_1143|Compound:3454-2408|FD-Score:-4.65|P-value:7.25E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:-5.78|P-value:1.21E-9 ID:SGTC_1147|Compound:3809-1045|FD-Score:-4.40|P-value:2.54E-6 ID:SGTC_1148|Compound:3909-7663|FD-Score:-4.84|P-value:2.74E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.35|P-value:2.50E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-8.09|P-value:4.12E-17 ID:SGTC_1163|Compound:k060-0048|FD-Score:-4.81|P-value:3.23E-7 ID:SGTC_1167|Compound:k781-0610|FD-Score:-4.84|P-value:2.81E-7 ID:SGTC_1168|Compound:k815-0004|FD-Score:-8.40|P-value:2.67E-18 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.88|P-value:2.82E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:-7.66|P-value:1.48E-15 ID:SGTC_1181|Compound:1222-0449|FD-Score:-3.86|P-value:3.15E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:-5.71|P-value:1.90E-9 ID:SGTC_1185|Compound:1319-0113|FD-Score:-6.60|P-value:5.07E-12 ID:SGTC_1186|Compound:1319-0216|FD-Score:-13.00|P-value:8.09E-41 ID:SGTC_1192|Compound:1488-0095|FD-Score:-16.90|P-value:8.37E-68 ID:SGTC_1200|Compound:1643-0193|FD-Score:-10.00|P-value:2.55E-25 ID:SGTC_1209|Compound:2323-2347|FD-Score:-12.80|P-value:1.65E-39 ID:SGTC_1222|Compound:0366-0074|FD-Score:-4.25|P-value:5.19E-6 ID:SGTC_1228|Compound:0124-0032|FD-Score:-5.43|P-value:1.01E-8 ID:SGTC_1232|Compound:0279-0259|FD-Score:-4.02|P-value:1.55E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:-4.77|P-value:3.99E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:-5.68|P-value:2.19E-9 ID:SGTC_1249|Compound:0481-0015|FD-Score:-5.46|P-value:8.59E-9 ID:SGTC_1250|Compound:0485-0349|FD-Score:-4.27|P-value:4.75E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:-16.10|P-value:1.04E-61 ID:SGTC_1256|Compound:0570-0116|FD-Score:-7.95|P-value:1.37E-16 ID:SGTC_1266|Compound:0828-0227|FD-Score:-16.90|P-value:2.41E-67 ID:SGTC_1271|Compound:0832-2808|FD-Score:-6.26|P-value:5.34E-11 ID:SGTC_1273|Compound:0849-0096|FD-Score:-8.64|P-value:2.97E-19 ID:SGTC_1274|Compound:0865-0114|FD-Score:-10.10|P-value:1.33E-25 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.69|P-value:6.06E-7 ID:SGTC_1311|Compound:1190-0148|FD-Score:-6.30|P-value:3.90E-11 ID:SGTC_1323|Compound:1348-1351|FD-Score:-4.46|P-value:1.91E-6 ID:SGTC_1347|Compound:1493-0251|FD-Score:-7.18|P-value:6.52E-14 ID:SGTC_1358|Compound:1509-0022|FD-Score:-11.30|P-value:2.49E-31 ID:SGTC_1361|Compound:1608-0041|FD-Score:-8.47|P-value:1.41E-18 ID:SGTC_1363|Compound:1636-0063|FD-Score:-6.74|P-value:1.82E-12 ID:SGTC_1845|Compound:st056753|FD-Score:-2.97|P-value:9.79E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.00|P-value:8.94E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-3.12|P-value:5.70E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.68|P-value:6.63E-5 ID:SGTC_1940|Compound:st075990|FD-Score:-3.18|P-value:4.72E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.88|P-value:2.80E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-3.54|P-value:1.18E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.07|P-value:6.92E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.07|P-value:6.92E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.53|P-value:1.34E-6 ID:SGTC_3127|Compound:9126946|FD-Score:-3.23|P-value:3.89E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:-4.33|P-value:3.66E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:-3.47|P-value:1.57E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.13|P-value:5.70E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.20|P-value:4.27E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.25|P-value:3.60E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-5.40|P-value:1.23E-8 ID:SGTC_373|Compound:0844-0104|FD-Score:-3.83|P-value:3.57E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-4.96|P-value:1.48E-7 ID:SGTC_531|Compound:3788-1495|FD-Score:-5.85|P-value:7.76E-10 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.45|P-value:1.69E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:-3.13|P-value:5.65E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-4.35|P-value:3.28E-6 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.60|P-value:9.19E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.93|P-value:2.29E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:-5.36|P-value:1.56E-8 ID:SGTC_811|Compound:0416-0114|FD-Score:-5.54|P-value:5.12E-9 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.23|P-value:3.94E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.65|P-value:7.51E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.96|P-value:2.00E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:-9.51|P-value:6.70E-23 ID:SGTC_914|Compound:3820-6779|FD-Score:-4.40|P-value:2.62E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-5.47|P-value:8.16E-9 ID:SGTC_921|Compound:1561-0023|FD-Score:-5.27|P-value:2.60E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.11|P-value:5.99E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.30|P-value:2.97E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.17|P-value:4.90E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-8.81|P-value:5.99E-20 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.65|P-value:7.41E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.01|P-value:8.42E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:-2.99|P-value:9.27E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.50|P-value:1.37E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:-5.55|P-value:4.85E-9 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.02|P-value:8.20E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:-4.20|P-value:6.73E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:-11.80|P-value:4.06E-34 ID:SGTC_1131|Compound:3454-3128|FD-Score:-13.40|P-value:1.05E-43 ID:SGTC_1132|Compound:3456-3614|FD-Score:-7.92|P-value:1.65E-16 ID:SGTC_1138|Compound:3761-0006|FD-Score:-5.28|P-value:2.38E-8 ID:SGTC_1139|Compound:k015-0024|FD-Score:-4.60|P-value:9.35E-7 ID:SGTC_1143|Compound:3454-2408|FD-Score:-4.65|P-value:7.25E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:-5.78|P-value:1.21E-9 ID:SGTC_1147|Compound:3809-1045|FD-Score:-4.40|P-value:2.54E-6 ID:SGTC_1148|Compound:3909-7663|FD-Score:-4.84|P-value:2.74E-7 ID:SGTC_1153|Compound:4055-0057|FD-Score:-3.35|P-value:2.50E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-8.09|P-value:4.12E-17 ID:SGTC_1163|Compound:k060-0048|FD-Score:-4.81|P-value:3.23E-7 ID:SGTC_1167|Compound:k781-0610|FD-Score:-4.84|P-value:2.81E-7 ID:SGTC_1168|Compound:k815-0004|FD-Score:-8.40|P-value:2.67E-18 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.88|P-value:2.82E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:-7.66|P-value:1.48E-15 ID:SGTC_1181|Compound:1222-0449|FD-Score:-3.86|P-value:3.15E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:-5.71|P-value:1.90E-9 ID:SGTC_1185|Compound:1319-0113|FD-Score:-6.60|P-value:5.07E-12 ID:SGTC_1186|Compound:1319-0216|FD-Score:-13.00|P-value:8.09E-41 ID:SGTC_1192|Compound:1488-0095|FD-Score:-16.90|P-value:8.37E-68 ID:SGTC_1200|Compound:1643-0193|FD-Score:-10.00|P-value:2.55E-25 ID:SGTC_1209|Compound:2323-2347|FD-Score:-12.80|P-value:1.65E-39 ID:SGTC_1222|Compound:0366-0074|FD-Score:-4.25|P-value:5.19E-6 ID:SGTC_1228|Compound:0124-0032|FD-Score:-5.43|P-value:1.01E-8 ID:SGTC_1232|Compound:0279-0259|FD-Score:-4.02|P-value:1.55E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:-4.77|P-value:3.99E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:-5.68|P-value:2.19E-9 ID:SGTC_1249|Compound:0481-0015|FD-Score:-5.46|P-value:8.59E-9 ID:SGTC_1250|Compound:0485-0349|FD-Score:-4.27|P-value:4.75E-6 ID:SGTC_1255|Compound:0566-0045|FD-Score:-16.10|P-value:1.04E-61 ID:SGTC_1256|Compound:0570-0116|FD-Score:-7.95|P-value:1.37E-16 ID:SGTC_1266|Compound:0828-0227|FD-Score:-16.90|P-value:2.41E-67 ID:SGTC_1271|Compound:0832-2808|FD-Score:-6.26|P-value:5.34E-11 ID:SGTC_1273|Compound:0849-0096|FD-Score:-8.64|P-value:2.97E-19 ID:SGTC_1274|Compound:0865-0114|FD-Score:-10.10|P-value:1.33E-25 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.69|P-value:6.06E-7 ID:SGTC_1311|Compound:1190-0148|FD-Score:-6.30|P-value:3.90E-11 ID:SGTC_1323|Compound:1348-1351|FD-Score:-4.46|P-value:1.91E-6 ID:SGTC_1347|Compound:1493-0251|FD-Score:-7.18|P-value:6.52E-14 ID:SGTC_1358|Compound:1509-0022|FD-Score:-11.30|P-value:2.49E-31 ID:SGTC_1361|Compound:1608-0041|FD-Score:-8.47|P-value:1.41E-18 ID:SGTC_1363|Compound:1636-0063|FD-Score:-6.74|P-value:1.82E-12 ID:SGTC_1845|Compound:st056753|FD-Score:-2.97|P-value:9.79E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.00|P-value:8.94E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-3.12|P-value:5.70E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.68|P-value:6.63E-5 ID:SGTC_1940|Compound:st075990|FD-Score:-3.18|P-value:4.72E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.88|P-value:2.80E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-3.54|P-value:1.18E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.07|P-value:6.92E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.07|P-value:6.92E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.53|P-value:1.34E-6 ID:SGTC_3127|Compound:9126946|FD-Score:-3.23|P-value:3.89E-4

Top fitness defect scores for YHL025W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3020 9089140 2.75 49.5 µM 0.00297 88 0.00302
2 SGTC_3028 9087778 2.72 49.5 µM 0.00325 70 0.00330
3 SGTC_51 1013-0126 2.69 23.4 µM 0.00349 83 0.00353
4 SGTC_669 0108-0021 2.60 26.2 µM 0.00466 fatty acid desaturase (OLE1) 202 0.00468
5 SGTC_3194 9111903 2.52 49.5 µM 0.00592 113 0.00592
6 SGTC_1702 st027038 2.51 51.0 µM 0.00602 99 0.00602
7 SGTC_2873 9040596 2.51 71.4 µM 0.00602 144 0.00602
8 SGTC_1871 st057448 2.49 67.3 µM 0.00634 117 0.00633
9 SGTC_3026 9090633 2.47 49.5 µM 0.00683 120 0.00681
10 SGTC_2481 5478948 2.46 45.2 µM 0.00688 PDR1 156 0.00685
11 SGTC_1719 st032227 2.46 49.2 µM 0.00695 128 0.00693
12 SGTC_2276 7947513 2.43 42.1 µM 0.00751 126 0.00747
13 SGTC_2485 5633444 2.38 17.8 µM 0.00865 redox potentiating 179 0.00858
14 SGTC_2060 5238662 2.38 140.0 µM 0.00880 133 0.00873
15 SGTC_2477 5967686 2.37 25.2 µM 0.00909 132 0.00901
16 SGTC_156 3474-0145 2.36 5.6 µM 0.00922 endomembrane recycling 176 0.00913
17 SGTC_2348 9022543 2.36 33.4 µM 0.00934 mitochondrial processes 147 0.00925
18 SGTC_1722 st034304 2.35 3.6 µM 0.00939 mitochondrial processes 170 0.00930
19 SGTC_2065 5221596 2.35 34.3 µM 0.00947 128 0.00937
20 SGTC_164 4100-3994 2.34 89.6 µM 0.00964 181 0.00954

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.60E-12 YBR289W SNF5 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions
0.109 2.28E-10 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
0.103 2.04E-9 YDR487C RIB3 het 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
0.085 7.05E-7 YDL091C UBX3 hom Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10
0.081 2.58E-6 YOL132W GAS4 hom 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
0.072 2.75E-5 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.069 6.29E-5 YGR262C BUD32 hom Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription
0.068 7.44E-5 YNL297C MON2 hom Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins
0.064 1.87E-4 YLR397C AFG2 het ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs
0.064 2.09E-4 YBL045C COR1 hom Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
0.061 3.89E-4 YMR167W MLH1 hom Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer
0.061 3.91E-4 YEL041W YEF1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication
0.060 4.65E-4 YOL117W RRI2 hom Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response
0.060 4.96E-4 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.059 6.79E-4 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction