YHL038C / CBP2

Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL038C / CBP2

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:2.82|P-value:8.70E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.02|P-value:4.16E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.71|P-value:1.52E-21 ID:SGTC_168|Compound:3970-0862|FD-Score:4.35|P-value:8.81E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:3.91|P-value:8.50E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:13.90|P-value:1.99E-51 ID:SGTC_310|Compound:1273-0058|FD-Score:4.51|P-value:3.83E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:2.83|P-value:8.51E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.10|P-value:3.32E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.88|P-value:2.32E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:6.10|P-value:1.36E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-2.98|P-value:9.53E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.14|P-value:2.53E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.27|P-value:1.52E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.68|P-value:2.53E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:2.83|P-value:8.36E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:2.79|P-value:9.65E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:2.86|P-value:7.62E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:2.86|P-value:7.46E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:2.84|P-value:8.01E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.07|P-value:3.42E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.62|P-value:3.26E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:2.98|P-value:4.84E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.35|P-value:1.05E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.48|P-value:1.04E-9 ID:SGTC_1659|Compound:st012954|FD-Score:-3.02|P-value:8.31E-4 ID:SGTC_1660|Compound:st012960|FD-Score:-3.46|P-value:1.44E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.98|P-value:1.42E-5 ID:SGTC_1862|Compound:st057513|FD-Score:2.91|P-value:6.29E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.34|P-value:1.14E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.56|P-value:4.23E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.83|P-value:2.93E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-4.24|P-value:4.02E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.37|P-value:1.00E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.02|P-value:4.06E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:5.43|P-value:1.49E-9 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.22|P-value:1.87E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.43|P-value:1.56E-6 ID:SGTC_2694|Compound:st077685|FD-Score:-4.21|P-value:4.78E-6 ID:SGTC_2927|Compound:9011802|FD-Score:3.00|P-value:4.50E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.00|P-value:4.41E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.35|P-value:1.09E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.52|P-value:5.12E-5 ID:SGTC_3002|Compound:9075603|FD-Score:-3.07|P-value:6.86E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:2.82|P-value:8.70E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.02|P-value:4.16E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.71|P-value:1.52E-21 ID:SGTC_168|Compound:3970-0862|FD-Score:4.35|P-value:8.81E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:3.91|P-value:8.50E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:13.90|P-value:1.99E-51 ID:SGTC_310|Compound:1273-0058|FD-Score:4.51|P-value:3.83E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:2.83|P-value:8.51E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.10|P-value:3.32E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.88|P-value:2.32E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:6.10|P-value:1.36E-11 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-2.98|P-value:9.53E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.14|P-value:2.53E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.27|P-value:1.52E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.68|P-value:2.53E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:2.83|P-value:8.36E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:2.79|P-value:9.65E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:2.86|P-value:7.62E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:2.86|P-value:7.46E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:2.84|P-value:8.01E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.07|P-value:3.42E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.62|P-value:3.26E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:2.98|P-value:4.84E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.35|P-value:1.05E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.48|P-value:1.04E-9 ID:SGTC_1659|Compound:st012954|FD-Score:-3.02|P-value:8.31E-4 ID:SGTC_1660|Compound:st012960|FD-Score:-3.46|P-value:1.44E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.98|P-value:1.42E-5 ID:SGTC_1862|Compound:st057513|FD-Score:2.91|P-value:6.29E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.34|P-value:1.14E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.56|P-value:4.23E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-3.83|P-value:2.93E-5 ID:SGTC_2291|Compound:7917025|FD-Score:-4.24|P-value:4.02E-6 ID:SGTC_2321|Compound:7390090|FD-Score:3.37|P-value:1.00E-4 ID:SGTC_2345|Compound:9052315|FD-Score:3.02|P-value:4.06E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:5.43|P-value:1.49E-9 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.22|P-value:1.87E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.43|P-value:1.56E-6 ID:SGTC_2694|Compound:st077685|FD-Score:-4.21|P-value:4.78E-6 ID:SGTC_2927|Compound:9011802|FD-Score:3.00|P-value:4.50E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.00|P-value:4.41E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.35|P-value:1.09E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.52|P-value:5.12E-5 ID:SGTC_3002|Compound:9075603|FD-Score:-3.07|P-value:6.86E-4

Top fitness defect scores for YHL038C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 13.90 5.3 µM 1.99E-51 119 3.43E-44
2 SGTC_134 0269-0018 8.71 6.9 µM 1.52E-21 51 1.56E-18
3 SGTC_386 1509-0011 6.10 3.1 µM 1.36E-11 91 5.22E-10
4 SGTC_1635 st007035 5.48 42.4 µM 1.04E-9 148 2.12E-8
5 SGTC_2605 digitonin 5.43 300.0 nM 1.49E-9 8 2.88E-8
6 SGTC_310 1273-0058 4.51 1.1 µM 3.83E-7 mitochondrial stress 211 3.30E-6
7 SGTC_168 3970-0862 4.35 530.5 µM 8.81E-7 96 6.72E-6
8 SGTC_366 0181-0206 4.10 4.3 µM 3.32E-6 Golgi 34 2.08E-5
9 SGTC_173 1273-0061 3.91 2.7 µM 8.50E-6 mitochondrial stress 189 4.65E-5
10 SGTC_650 1328-0195 3.68 38.0 µM 2.53E-5 24 1.18E-4
11 SGTC_1314 1222-0010 3.62 41.1 µM 3.26E-5 16 1.46E-4
12 SGTC_2175 5807670 3.56 165.3 µM 4.23E-5 28 1.82E-4
13 SGTC_2960 9079389 3.52 6.0 µM 5.12E-5 46 2.15E-4
14 SGTC_2321 7390090 3.37 138.8 µM 1.00E-4 52 3.80E-4
15 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 3.35 66.5 µM 1.05E-4 28 3.97E-4
16 SGTC_2929 9013348 3.35 24.6 µM 1.09E-4 46 4.10E-4
17 SGTC_2032 5185112 3.34 26.0 µM 1.14E-4 23 4.25E-4
18 SGTC_503 tyrphostin 8 3.27 294.0 µM 1.52E-4 TSC3-RPN4 56 5.43E-4
19 SGTC_2608 thymoquinone 3.22 42.7 µM 1.87E-4 38 6.48E-4
20 SGTC_501 nsc-95397 3.14 161.0 µM 2.53E-4 34 8.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.625 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.620 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.620 0 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.598 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.597 9.88E-324 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.596 1.58E-322 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.587 4.99E-310 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.586 6.29E-308 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.575 1.09E-294 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.572 2.87E-291 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.570 4.76E-288 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.568 9.98E-286 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.557 2.54E-272 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.555 5.49E-271 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.555 9.96E-271 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex