YHL040C / ARN1

ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YHL040C / ARN1

Click on Significant Values for Screen Details ID:SGTC_126|Compound:0417-1624|FD-Score:-4.14|P-value:5.56E-6 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.98|P-value:8.22E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.04|P-value:5.19E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.72|P-value:3.21E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.92|P-value:1.64E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.34|P-value:1.99E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.26|P-value:3.15E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.75|P-value:3.45E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:2.99|P-value:6.27E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.56|P-value:4.92E-7 ID:SGTC_1115|Compound:galangin|FD-Score:4.17|P-value:3.79E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.45|P-value:1.02E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.94|P-value:7.80E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:2.87|P-value:9.79E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.27|P-value:2.17E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.39|P-value:1.32E-4 ID:SGTC_1906|Compound:st060206|FD-Score:2.91|P-value:8.69E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-2.93|P-value:9.54E-4 ID:SGTC_2013|Compound:4024628|FD-Score:4.65|P-value:2.89E-7 ID:SGTC_2058|Compound:5236698|FD-Score:-3.59|P-value:7.13E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-3.12|P-value:4.77E-4 ID:SGTC_2331|Compound:7980721|FD-Score:2.90|P-value:8.94E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-2.98|P-value:8.07E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.14|P-value:3.57E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.23|P-value:2.55E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.98|P-value:1.25E-5 ID:SGTC_3220|Compound:9131269|FD-Score:-3.93|P-value:1.54E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:-4.14|P-value:5.56E-6 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.98|P-value:8.22E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:3.04|P-value:5.19E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.72|P-value:3.21E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.92|P-value:1.64E-5 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.34|P-value:1.99E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.26|P-value:3.15E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.75|P-value:3.45E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:2.99|P-value:6.27E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.56|P-value:4.92E-7 ID:SGTC_1115|Compound:galangin|FD-Score:4.17|P-value:3.79E-6 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.45|P-value:1.02E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:2.94|P-value:7.80E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:2.87|P-value:9.79E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.27|P-value:2.17E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.39|P-value:1.32E-4 ID:SGTC_1906|Compound:st060206|FD-Score:2.91|P-value:8.69E-4 ID:SGTC_1943|Compound:st076331|FD-Score:-2.93|P-value:9.54E-4 ID:SGTC_2013|Compound:4024628|FD-Score:4.65|P-value:2.89E-7 ID:SGTC_2058|Compound:5236698|FD-Score:-3.59|P-value:7.13E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-3.12|P-value:4.77E-4 ID:SGTC_2331|Compound:7980721|FD-Score:2.90|P-value:8.94E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-2.98|P-value:8.07E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.14|P-value:3.57E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.23|P-value:2.55E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.98|P-value:1.25E-5 ID:SGTC_3220|Compound:9131269|FD-Score:-3.93|P-value:1.54E-5

Top fitness defect scores for YHL040C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2013 4024628 4.65 200.0 µM 2.89E-7 29 1.62E-6
2 SGTC_911 3456-4043 4.56 236.0 µM 4.92E-7 mitochondrial processes 18 2.59E-6
3 SGTC_1115 galangin 4.17 695.7 nM 3.79E-6 RPP1 & pyrimidine depletion 8 1.55E-5
4 SGTC_369 0957-0393 3.72 4.5 µM 3.21E-5 cell wall signaling 31 1.01E-4
5 SGTC_1248 0469-0687 3.45 58.6 µM 1.02E-4 49 2.80E-4
6 SGTC_1843 st055809 3.39 45.5 µM 1.32E-4 34 3.49E-4
7 SGTC_1835 st008666 3.27 49.2 µM 2.17E-4 42 5.41E-4
8 SGTC_2602 kawain 3.23 100.0 µM 2.55E-4 58 6.22E-4
9 SGTC_2469 5655019 3.14 90.8 µM 3.57E-4 49 8.37E-4
10 SGTC_245 methotrexate 3.04 289.6 µM 5.19E-4 84 0.00116
11 SGTC_891 0929-0073 2.99 133.0 µM 6.27E-4 64 0.00137
12 SGTC_1309 pyrazolanthrone 2.94 13.4 µM 7.80E-4 62 0.00166
13 SGTC_1906 st060206 2.91 94.7 µM 8.69E-4 74 0.00183
14 SGTC_2331 7980721 2.90 200.0 µM 8.94E-4 81 0.00188
15 SGTC_1389 3405-0187 2.87 19.0 µM 9.79E-4 63 0.00203
16 SGTC_1352 1496-0991 2.84 99.0 µM 0.00109 tubulin folding & SWR complex 72 0.00223
17 SGTC_1101 ebselen 2.80 5.3 µM 0.00125 77 0.00253
18 SGTC_1989 st071868 2.79 50.2 µM 0.00131 66 0.00262
19 SGTC_527 4476-4215 2.77 268.0 µM 0.00141 PDR1 109 0.00281
20 SGTC_249 wiskostatin 2.75 11.2 µM 0.00153 67 0.00301

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.23E-22 YDL149W ATG9 hom Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS
0.152 7.42E-19 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.142 1.08E-16 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.127 1.91E-13 YML116W-A_d YML116W-A_d hom Putative protein of unknown function
0.126 2.19E-13 YFL003C MSH4 hom Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
0.123 7.96E-13 YLR259C HSP60 het Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
0.119 4.16E-12 YGL243W TAD1 hom tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
0.116 1.90E-11 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.113 5.87E-11 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.113 5.93E-11 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.112 7.11E-11 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.111 1.02E-10 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.109 2.71E-10 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.106 6.57E-10 YDL004W ATP16 het Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.106 8.50E-10 YLR060W FRS1 het Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control