| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|
| 0.374 |
7.93E-112 |
YDL155W |
CLB3 |
hom |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress |
| 0.364 |
1.67E-105 |
YPL246C |
RBD2 |
hom |
Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p |
| 0.344 |
1.00E-93 |
YML029W |
USA1 |
hom |
Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p |
| 0.343 |
1.88E-93 |
YGL090W |
LIF1 |
hom |
Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein |
| 0.316 |
1.11E-78 |
YIL009W |
FAA3 |
hom |
Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
| 0.314 |
8.51E-78 |
YLR040C_p |
YLR040C_p |
hom |
Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential |
| 0.301 |
2.90E-71 |
YOR271C_p |
FSF1_p |
hom |
Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis |
| 0.301 |
3.97E-71 |
YNL123W |
NMA111 |
hom |
Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases |
| 0.294 |
8.31E-68 |
YDL022W |
GPD1 |
hom |
NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity |
| 0.285 |
6.88E-64 |
YLR317W_d |
YLR317W_d |
het |
Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C |
| 0.279 |
3.85E-61 |
YGR018C_p |
YGR018C_p |
hom |
Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W |
| 0.266 |
2.31E-55 |
YLR034C |
SMF3 |
hom |
Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress |
| 0.262 |
1.35E-53 |
YML025C |
YML6 |
het |
Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins |
| 0.254 |
9.58E-51 |
YNL103W |
MET4 |
het |
Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p |
| 0.251 |
2.32E-49 |
YLR440C |
SEC39 |
het |
Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope |
