HIPHOP chemogenomics database

YHR007C / ERG11

Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p

Zygosity: Heterozygous strain

fixedexpanded
Profile for YHR007C / ERG11

Click on Significant Values for Screen Details

Top fitness defect scores for YHR007C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_1788	fluconazole	22.20	20.0 µM	1.35E-57	azole & statin	1	3.77E-109	15.40
2	SGTC_2991	9074669	19.80	71.4 µM	1.40E-46	azole & statin	1	6.65E-88	4.75
3	SGTC_1873	rapamycin	19.30	2.0 nM	3.46E-44		2	2.73E-83	6.77
4	SGTC_659	k018-0002	19.10	107.0 µM	3.57E-43		1	2.44E-81	12.20
5	SGTC_221	trifluoperazine	18.60	10.3 µM	5.40E-41	NEO1-PIK1	3	3.90E-77	2.33
6	SGTC_783	0848-0141	16.70	92.7 µM	9.41E-34	RSC & ERG11	2	3.48E-63	9.02
7	SGTC_2567	aureobasidin a	16.60	60.0 nM	3.83E-33		7	5.20E-62	3.52
8	SGTC_145	3737-0113	16.10	38.4 µM	1.58E-31	DNA intercalators	2	6.71E-59	4.52
9	SGTC_643	k048-0106	15.40	28.4 µM	6.34E-29	RSC & ERG11	3	6.88E-54	2.87
10	SGTC_2648	atorvastatin	15.00	78.7 µM	1.20E-27	azole & statin	1	1.96E-51	8.05
11	SGTC_1083	didemethylchlorpromazine sulfoxide	14.40	707.4 nM	2.13E-25	redox potentiating	4	4.20E-47	0.86
12	SGTC_1026	k007-1105	14.30	30.6 µM	4.40E-25	ERAD & cell cycle	4	1.69E-46	4.23
13	SGTC_1731	st035964	13.30	63.0 µM	3.37E-22		1	5.93E-41	4.14
14	SGTC_632	0781-2353	13.10	4.7 µM	2.51E-21	Golgi	1	2.81E-39	5.79
15	SGTC_227	fluconazole	12.90	33.5 µM	1.01E-20	azole & statin	9	4.07E-38	0.24
16	SGTC_868	0527-0199	12.70	213.0 µM	2.93E-20	fatty acid desaturase (OLE1)	1	3.15E-37	4.85
17	SGTC_2765	myclobutanil	12.60	7.7 µM	4.56E-20	azole & statin	1	7.37E-37	7.25
18	SGTC_875	0709-0210	12.30	25.7 µM	3.48E-19	fatty acid desaturase (OLE1)	1	3.65E-35	3.41
19	SGTC_637	1181-0519	11.80	7.3 µM	8.86E-18	fatty acid desaturase (OLE1)	3	1.81E-32	3.64
20	SGTC_2398	5228213	11.80	48.8 µM	9.73E-18	iron homeostasis	2	2.17E-32	2.59

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.375	1.29E-112	YOR319W	HSH49	het	U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
0.279	4.95E-61	YCR093W	CDC39	het	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.258	4.71E-52	YJR102C	VPS25	hom	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.251	2.28E-49	YOR157C	PUP1	het	Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
0.249	1.56E-48	YGL116W	CDC20	het	Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.246	2.65E-47	YOR357C	SNX3	hom	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.228	6.80E-41	YLR025W	SNF7	hom	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.228	1.53E-40	YMR154C	RIM13	hom	Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.227	1.53E-40	YML037C_p	YML037C_p	hom	Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.225	1.08E-39	YNL267W	PIK1	het	Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.225	8.66E-40	YER031C	YPT31	hom	Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.224	2.08E-39	YFL034W_p	YFL034W_p	hom	Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.219	7.82E-38	YJL154C	VPS35	hom	Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.218	2.46E-37	YMR071C	TVP18	hom	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.217	3.41E-37	YHL019C	APM2	hom	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport