YHR033W_p

Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR033W / YHR033W

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.83|P-value:2.87E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:2.70|P-value:7.72E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-2.78|P-value:4.93E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:2.95|P-value:2.73E-4 ID:SGTC_394|Compound:menadione|FD-Score:5.09|P-value:1.06E-9 ID:SGTC_406|Compound:estrone|FD-Score:2.97|P-value:2.49E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.20|P-value:8.46E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:-2.72|P-value:6.32E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-2.67|P-value:7.78E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-2.68|P-value:7.46E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:2.74|P-value:6.46E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.43|P-value:2.41E-5 ID:SGTC_459|Compound:nigericin|FD-Score:-3.29|P-value:4.83E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:-2.94|P-value:2.42E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:2.87|P-value:3.86E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.80|P-value:4.53E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.18|P-value:9.32E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:3.16|P-value:1.03E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.28|P-value:5.83E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.01|P-value:1.79E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.35|P-value:4.29E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:4.39|P-value:1.27E-7 ID:SGTC_998|Compound:3996-0085|FD-Score:4.03|P-value:1.08E-6 ID:SGTC_1012|Compound:4112-3522|FD-Score:2.67|P-value:8.61E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.61|P-value:9.92E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.88|P-value:3.22E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.06|P-value:1.64E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.24|P-value:6.99E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.27|P-value:5.43E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:2.92|P-value:3.10E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:2.81|P-value:4.98E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:2.85|P-value:4.14E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:2.86|P-value:3.89E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-2.64|P-value:8.55E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-2.85|P-value:3.58E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-2.66|P-value:7.90E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.22|P-value:3.63E-7 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.09|P-value:7.95E-7 ID:SGTC_1906|Compound:st060206|FD-Score:2.95|P-value:2.72E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-2.69|P-value:7.13E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.45|P-value:2.62E-5 ID:SGTC_2349|Compound:9023730|FD-Score:4.39|P-value:1.28E-7 ID:SGTC_2354|Compound:9060492|FD-Score:-5.06|P-value:1.12E-9 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.67|P-value:8.86E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.87|P-value:3.75E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-2.67|P-value:7.85E-4 ID:SGTC_2809|Compound:7964133|FD-Score:2.81|P-value:4.89E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-2.64|P-value:8.87E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-2.72|P-value:6.29E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-2.65|P-value:8.53E-4 ID:SGTC_2886|Compound:9058944|FD-Score:2.81|P-value:4.81E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.74|P-value:4.80E-6 ID:SGTC_2898|Compound:9056270|FD-Score:4.36|P-value:1.49E-7 ID:SGTC_2903|Compound:5923464|FD-Score:-2.69|P-value:7.00E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-2.61|P-value:9.77E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.05|P-value:1.71E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-2.83|P-value:3.95E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.83|P-value:2.87E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:2.70|P-value:7.72E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:-2.78|P-value:4.93E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:2.95|P-value:2.73E-4 ID:SGTC_394|Compound:menadione|FD-Score:5.09|P-value:1.06E-9 ID:SGTC_406|Compound:estrone|FD-Score:2.97|P-value:2.49E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.20|P-value:8.46E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:-2.72|P-value:6.32E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-2.67|P-value:7.78E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:-2.68|P-value:7.46E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:2.74|P-value:6.46E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.43|P-value:2.41E-5 ID:SGTC_459|Compound:nigericin|FD-Score:-3.29|P-value:4.83E-5 ID:SGTC_485|Compound:niflumic acid|FD-Score:-2.94|P-value:2.42E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:2.87|P-value:3.86E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.80|P-value:4.53E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.18|P-value:9.32E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:3.16|P-value:1.03E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.28|P-value:5.83E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.01|P-value:1.79E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.35|P-value:4.29E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:4.39|P-value:1.27E-7 ID:SGTC_998|Compound:3996-0085|FD-Score:4.03|P-value:1.08E-6 ID:SGTC_1012|Compound:4112-3522|FD-Score:2.67|P-value:8.61E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.61|P-value:9.92E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.88|P-value:3.22E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.06|P-value:1.64E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.24|P-value:6.99E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.27|P-value:5.43E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:2.92|P-value:3.10E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:2.81|P-value:4.98E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:2.85|P-value:4.14E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:2.86|P-value:3.89E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-2.64|P-value:8.55E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-2.85|P-value:3.58E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-2.66|P-value:7.90E-4 ID:SGTC_1868|Compound:st057644|FD-Score:4.22|P-value:3.63E-7 ID:SGTC_1875|Compound:nocodazole|FD-Score:4.09|P-value:7.95E-7 ID:SGTC_1906|Compound:st060206|FD-Score:2.95|P-value:2.72E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-2.69|P-value:7.13E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.45|P-value:2.62E-5 ID:SGTC_2349|Compound:9023730|FD-Score:4.39|P-value:1.28E-7 ID:SGTC_2354|Compound:9060492|FD-Score:-5.06|P-value:1.12E-9 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.67|P-value:8.86E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:2.87|P-value:3.75E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-2.67|P-value:7.85E-4 ID:SGTC_2809|Compound:7964133|FD-Score:2.81|P-value:4.89E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-2.64|P-value:8.87E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-2.72|P-value:6.29E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-2.65|P-value:8.53E-4 ID:SGTC_2886|Compound:9058944|FD-Score:2.81|P-value:4.81E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.74|P-value:4.80E-6 ID:SGTC_2898|Compound:9056270|FD-Score:4.36|P-value:1.49E-7 ID:SGTC_2903|Compound:5923464|FD-Score:-2.69|P-value:7.00E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-2.61|P-value:9.77E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.05|P-value:1.71E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-2.83|P-value:3.95E-4

Top fitness defect scores for YHR033W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_394 menadione 5.09 8.3 µM 1.06E-9 superoxide 16 1.76E-7
2 SGTC_996 3970-0799 4.39 1.8 µM 1.27E-7 67 5.76E-6
3 SGTC_2349 9023730 4.39 187.1 µM 1.28E-7 14 5.78E-6
4 SGTC_2898 9056270 4.36 58.4 µM 1.49E-7 4 6.46E-6
5 SGTC_1868 st057644 4.22 42.7 µM 3.63E-7 27 1.24E-5
6 SGTC_1875 nocodazole 4.09 6.0 µM 7.95E-7 tubulin folding & SWR complex 47 2.20E-5
7 SGTC_998 3996-0085 4.03 177.0 µM 1.08E-6 16 2.76E-5
8 SGTC_2086 5274770 3.45 176.6 µM 2.62E-5 39 2.85E-4
9 SGTC_993 3909-8757 3.35 62.7 µM 4.29E-5 43 4.10E-4
10 SGTC_944 3370-0224 3.28 231.0 µM 5.83E-5 51 5.14E-4
11 SGTC_1257 0669-0121 3.24 16.0 µM 6.99E-5 60 5.88E-4
12 SGTC_417 st075190 3.20 100.0 µM 8.46E-5 35 6.76E-4
13 SGTC_762 1165-0429 3.18 115.0 µM 9.32E-5 TSC3-RPN4 47 7.27E-4
14 SGTC_847 0342-0274 3.16 5.5 µM 1.03E-4 48 7.84E-4
15 SGTC_1180 1193-0155 3.06 285.0 µM 1.64E-4 54 0.00110
16 SGTC_3266 9136860 3.05 49.5 µM 1.71E-4 cell wall 85 0.00114
17 SGTC_406 estrone 2.97 100.0 µM 2.49E-4 40 0.00150
18 SGTC_1906 st060206 2.95 94.7 µM 2.72E-4 67 0.00160
19 SGTC_378 3970-0959 2.95 8.3 µM 2.73E-4 52 0.00161
20 SGTC_1331 1472-0049 2.92 76.2 µM 3.10E-4 74 0.00176

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.256 2.12E-51 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.208 5.48E-34 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.187 8.05E-28 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.179 1.30E-25 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.179 1.50E-25 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.160 1.59E-20 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.152 8.54E-19 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.149 4.65E-18 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.138 1.20E-15 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.132 1.33E-14 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.130 4.62E-14 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.126 2.26E-13 YPL223C GRE1 hom Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
0.125 3.16E-13 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.124 4.68E-13 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.121 1.71E-12 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance