YHR035W_p

Putative protein of unknown function; not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR035W / YHR035W

Click on Significant Values for Screen Details ID:SGTC_331|Compound:k048-0133|FD-Score:-2.82|P-value:6.32E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:-2.93|P-value:4.05E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.47|P-value:9.72E-8 ID:SGTC_543|Compound:3844-1095|FD-Score:3.14|P-value:1.22E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.14|P-value:1.64E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:2.82|P-value:4.78E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.95|P-value:2.94E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:2.72|P-value:7.18E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:2.87|P-value:4.00E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.88|P-value:6.65E-9 ID:SGTC_1184|Compound:1269-1718|FD-Score:2.93|P-value:3.02E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.86|P-value:3.40E-6 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.45|P-value:3.78E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:2.70|P-value:7.71E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.65|P-value:1.03E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.15|P-value:1.17E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:2.84|P-value:4.54E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:2.72|P-value:7.40E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-2.80|P-value:6.81E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.07|P-value:1.68E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.16|P-value:1.45E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-3.10|P-value:1.95E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:-2.81|P-value:6.40E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.92|P-value:4.09E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.02|P-value:2.05E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.93|P-value:3.18E-6 ID:SGTC_1763|Compound:st044482|FD-Score:3.17|P-value:1.05E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.70|P-value:7.73E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.18|P-value:8.03E-7 ID:SGTC_1959|Compound:st077091|FD-Score:-3.59|P-value:1.93E-5 ID:SGTC_2036|Compound:5160441|FD-Score:-3.15|P-value:1.56E-4 ID:SGTC_2152|Compound:5568786|FD-Score:2.95|P-value:2.76E-4 ID:SGTC_2206|Compound:7254556|FD-Score:2.75|P-value:6.53E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.82|P-value:4.25E-6 ID:SGTC_2245|Compound:6637752|FD-Score:2.67|P-value:8.77E-4 ID:SGTC_2293|Compound:7624732|FD-Score:2.94|P-value:2.97E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.05|P-value:1.81E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.55|P-value:2.33E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:2.87|P-value:3.93E-4 ID:SGTC_2744|Compound:captopril|FD-Score:5.19|P-value:7.52E-10 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.42|P-value:4.40E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-4.02|P-value:1.95E-6 ID:SGTC_2821|Compound:7996764|FD-Score:3.21|P-value:8.82E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.36|P-value:4.43E-5 ID:SGTC_2831|Compound:7999036|FD-Score:2.94|P-value:2.87E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.09|P-value:1.97E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.05|P-value:2.43E-4 ID:SGTC_2980|Compound:9014342|FD-Score:2.99|P-value:2.35E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.69|P-value:8.24E-6 ID:SGTC_3101|Compound:9120531|FD-Score:3.08|P-value:1.59E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.27|P-value:8.93E-5 ID:SGTC_3211|Compound:9128781|FD-Score:4.15|P-value:6.66E-7 ID:SGTC_3259|Compound:9138485|FD-Score:-3.73|P-value:9.42E-6 ID:SGTC_3260|Compound:9137109|FD-Score:2.94|P-value:2.89E-4 ID:SGTC_3264|Compound:9137442|FD-Score:4.58|P-value:4.65E-8 ID:SGTC_3275|Compound:9138069|FD-Score:3.66|P-value:9.59E-6 ID:SGTC_3279|Compound:9140807|FD-Score:-2.83|P-value:5.95E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-2.82|P-value:6.25E-4 ID:SGTC_331|Compound:k048-0133|FD-Score:-2.82|P-value:6.32E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:-2.93|P-value:4.05E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:4.47|P-value:9.72E-8 ID:SGTC_543|Compound:3844-1095|FD-Score:3.14|P-value:1.22E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.14|P-value:1.64E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:2.82|P-value:4.78E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.95|P-value:2.94E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:2.72|P-value:7.18E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:2.87|P-value:4.00E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.88|P-value:6.65E-9 ID:SGTC_1184|Compound:1269-1718|FD-Score:2.93|P-value:3.02E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.86|P-value:3.40E-6 ID:SGTC_1254|Compound:0550-0035|FD-Score:-3.45|P-value:3.78E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:2.70|P-value:7.71E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.65|P-value:1.03E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.15|P-value:1.17E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:2.84|P-value:4.54E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:2.72|P-value:7.40E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:-2.80|P-value:6.81E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.07|P-value:1.68E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.16|P-value:1.45E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-3.10|P-value:1.95E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:-2.81|P-value:6.40E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.92|P-value:4.09E-4 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.02|P-value:2.05E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.93|P-value:3.18E-6 ID:SGTC_1763|Compound:st044482|FD-Score:3.17|P-value:1.05E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.70|P-value:7.73E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.18|P-value:8.03E-7 ID:SGTC_1959|Compound:st077091|FD-Score:-3.59|P-value:1.93E-5 ID:SGTC_2036|Compound:5160441|FD-Score:-3.15|P-value:1.56E-4 ID:SGTC_2152|Compound:5568786|FD-Score:2.95|P-value:2.76E-4 ID:SGTC_2206|Compound:7254556|FD-Score:2.75|P-value:6.53E-4 ID:SGTC_2211|Compound:7117706|FD-Score:3.82|P-value:4.25E-6 ID:SGTC_2245|Compound:6637752|FD-Score:2.67|P-value:8.77E-4 ID:SGTC_2293|Compound:7624732|FD-Score:2.94|P-value:2.97E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.05|P-value:1.81E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.55|P-value:2.33E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:2.87|P-value:3.93E-4 ID:SGTC_2744|Compound:captopril|FD-Score:5.19|P-value:7.52E-10 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.42|P-value:4.40E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-4.02|P-value:1.95E-6 ID:SGTC_2821|Compound:7996764|FD-Score:3.21|P-value:8.82E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.36|P-value:4.43E-5 ID:SGTC_2831|Compound:7999036|FD-Score:2.94|P-value:2.87E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.09|P-value:1.97E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.05|P-value:2.43E-4 ID:SGTC_2980|Compound:9014342|FD-Score:2.99|P-value:2.35E-4 ID:SGTC_3056|Compound:9094900|FD-Score:3.69|P-value:8.24E-6 ID:SGTC_3101|Compound:9120531|FD-Score:3.08|P-value:1.59E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.27|P-value:8.93E-5 ID:SGTC_3211|Compound:9128781|FD-Score:4.15|P-value:6.66E-7 ID:SGTC_3259|Compound:9138485|FD-Score:-3.73|P-value:9.42E-6 ID:SGTC_3260|Compound:9137109|FD-Score:2.94|P-value:2.89E-4 ID:SGTC_3264|Compound:9137442|FD-Score:4.58|P-value:4.65E-8 ID:SGTC_3275|Compound:9138069|FD-Score:3.66|P-value:9.59E-6 ID:SGTC_3279|Compound:9140807|FD-Score:-2.83|P-value:5.95E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-2.82|P-value:6.25E-4

Top fitness defect scores for YHR035W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2744 captopril 5.19 92.0 µM 7.52E-10 60S ribosome export 4 1.04E-7
2 SGTC_1182 1222-0449 4.88 220.0 µM 6.65E-9 5 5.34E-7
3 SGTC_3264 9137442 4.58 49.5 µM 4.65E-8 8 2.29E-6
4 SGTC_534 k292-0788 4.47 63.4 µM 9.72E-8 mitochondrial processes 21 3.99E-6
5 SGTC_3211 9128781 4.15 49.5 µM 6.66E-7 49 1.69E-5
6 SGTC_1253 0550-0034 3.86 176.0 µM 3.40E-6 23 5.74E-5
7 SGTC_2211 7117706 3.82 200.0 µM 4.25E-6 15 6.79E-5
8 SGTC_3056 9094900 3.69 49.5 µM 8.24E-6 30 1.12E-4
9 SGTC_3275 9138069 3.66 49.5 µM 9.59E-6 9 1.25E-4
10 SGTC_1297 1068-0111 3.65 14.1 µM 1.03E-5 16 1.32E-4
11 SGTC_2823 7987624 3.36 58.4 µM 4.43E-5 62 3.96E-4
12 SGTC_2821 7996764 3.21 71.4 µM 8.82E-5 72 6.64E-4
13 SGTC_1763 st044482 3.17 94.5 µM 1.05E-4 copper-dependent oxidative stress 41 7.56E-4
14 SGTC_1344 1488-0097 3.15 29.1 µM 1.17E-4 47 8.23E-4
15 SGTC_543 3844-1095 3.14 191.0 µM 1.22E-4 ERG2 85 8.51E-4
16 SGTC_3101 9120531 3.08 49.5 µM 1.59E-4 69 0.00104
17 SGTC_1507 4075-3230 3.07 155.0 µM 1.68E-4 28 0.00108
18 SGTC_2529 gangaleoidin 3.05 93.6 µM 1.81E-4 48 0.00114
19 SGTC_1561 5-methoxyflavone 3.02 52.9 µM 2.05E-4 21 0.00126
20 SGTC_2980 9014342 2.99 25.3 µM 2.35E-4 82 0.00139

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.18E-17 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.131 2.70E-14 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.111 1.07E-10 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.106 8.46E-10 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.105 1.23E-9 YOR024W_d YOR024W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.103 1.88E-9 YLR254C NDL1 hom Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
0.102 3.21E-9 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.101 5.10E-9 YKL151C YKL151C hom NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.100 6.22E-9 YNL046W_p YNL046W_p hom Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.099 1.08E-8 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.096 2.42E-8 YGR103W NOP7 het Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation
0.096 2.65E-8 YER038W-A_d YER038W-A_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
0.094 4.31E-8 YPL188W POS5 hom Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress
0.092 9.08E-8 YLL025W PAU17 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene
0.089 2.55E-7 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W