YHR061C / GIC1

Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR061C / GIC1

Click on Significant Values for Screen Details ID:SGTC_112|Compound:phenothiazine|FD-Score:3.41|P-value:1.97E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.29|P-value:3.07E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.71|P-value:5.78E-5 ID:SGTC_280|Compound:3448-3607|FD-Score:2.98|P-value:9.82E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.11|P-value:6.17E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.59|P-value:9.62E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.35|P-value:2.31E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.01|P-value:8.70E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:4.36|P-value:2.87E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.62|P-value:7.52E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:5.04|P-value:7.98E-8 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.01|P-value:8.82E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.13|P-value:5.19E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.35|P-value:2.26E-4 ID:SGTC_1516|Compound:st013856|FD-Score:-4.02|P-value:1.32E-5 ID:SGTC_1752|Compound:st044819|FD-Score:4.41|P-value:2.26E-6 ID:SGTC_1758|Compound:st042942|FD-Score:4.06|P-value:1.22E-5 ID:SGTC_1759|Compound:st043059|FD-Score:4.16|P-value:7.45E-6 ID:SGTC_1764|Compound:st044502|FD-Score:3.85|P-value:3.17E-5 ID:SGTC_2073|Compound:5212005|FD-Score:3.24|P-value:3.84E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.54|P-value:1.16E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.40|P-value:1.89E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.60|P-value:8.37E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:5.85|P-value:5.56E-10 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.44|P-value:1.61E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.54|P-value:1.05E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.86|P-value:2.98E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.12|P-value:5.90E-4 ID:SGTC_2955|Compound:9076254|FD-Score:4.01|P-value:1.49E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.46|P-value:1.62E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:3.41|P-value:1.97E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.29|P-value:3.07E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.71|P-value:5.78E-5 ID:SGTC_280|Compound:3448-3607|FD-Score:2.98|P-value:9.82E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:3.11|P-value:6.17E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:3.59|P-value:9.62E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.35|P-value:2.31E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.01|P-value:8.70E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:4.36|P-value:2.87E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.62|P-value:7.52E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:5.04|P-value:7.98E-8 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.01|P-value:8.82E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:-3.13|P-value:5.19E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.35|P-value:2.26E-4 ID:SGTC_1516|Compound:st013856|FD-Score:-4.02|P-value:1.32E-5 ID:SGTC_1752|Compound:st044819|FD-Score:4.41|P-value:2.26E-6 ID:SGTC_1758|Compound:st042942|FD-Score:4.06|P-value:1.22E-5 ID:SGTC_1759|Compound:st043059|FD-Score:4.16|P-value:7.45E-6 ID:SGTC_1764|Compound:st044502|FD-Score:3.85|P-value:3.17E-5 ID:SGTC_2073|Compound:5212005|FD-Score:3.24|P-value:3.84E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.54|P-value:1.16E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.40|P-value:1.89E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.60|P-value:8.37E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:5.85|P-value:5.56E-10 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.44|P-value:1.61E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-4.54|P-value:1.05E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.86|P-value:2.98E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.12|P-value:5.90E-4 ID:SGTC_2955|Compound:9076254|FD-Score:4.01|P-value:1.49E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.46|P-value:1.62E-4

Top fitness defect scores for YHR061C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2605 digitonin 5.85 300.0 nM 5.56E-10 4 2.44E-9
2 SGTC_1004 4084-0029 5.04 199.0 µM 7.98E-8 5 2.39E-7
3 SGTC_1752 st044819 4.41 83.0 µM 2.26E-6 18 5.24E-6
4 SGTC_803 4488-1585 4.36 147.0 µM 2.87E-6 10 6.54E-6
5 SGTC_1759 st043059 4.16 70.0 µM 7.45E-6 amide catabolism 20 1.58E-5
6 SGTC_1758 st042942 4.06 75.2 µM 1.22E-5 17 2.50E-5
7 SGTC_2955 9076254 4.01 12.2 µM 1.49E-5 16 3.00E-5
8 SGTC_2615 purpurogallin-4-carboxylic acid 3.86 100.0 µM 2.98E-5 redox potentiating 68 5.69E-5
9 SGTC_1764 st044502 3.85 93.5 µM 3.17E-5 33 6.02E-5
10 SGTC_121 0557-0495 3.71 61.3 µM 5.78E-5 calcium & mitochondrial duress 69 1.05E-4
11 SGTC_330 1488-0319 3.59 80.1 µM 9.62E-5 RPP1 & pyrimidine depletion 18 1.68E-4
12 SGTC_2346 9031566 3.54 143.8 µM 1.16E-4 Golgi 40 2.00E-4
13 SGTC_3004 9076122 3.46 71.4 µM 1.62E-4 28 2.73E-4
14 SGTC_112 phenothiazine 3.41 287.2 µM 1.97E-4 unfolded protein response 25 3.26E-4
15 SGTC_116 0155-0182 3.29 31.8 µM 3.07E-4 mitochondrial response to ROS 128 4.92E-4
16 SGTC_2073 5212005 3.24 126.0 µM 3.84E-4 19 6.06E-4
17 SGTC_2933 9026794 3.12 32.5 µM 5.90E-4 65 9.03E-4
18 SGTC_321 4534-3890 3.11 65.3 µM 6.17E-4 RPP1 & pyrimidine depletion 20 9.41E-4
19 SGTC_623 k072-0108 3.01 16.9 µM 8.70E-4 heme biosynthesis & mitochondrial translocase 64 0.00129
20 SGTC_1006 4099-6547 3.01 255.0 µM 8.82E-4 76 0.00131

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.64E-22 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.151 1.27E-18 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.140 3.74E-16 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.115 2.72E-11 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.114 4.13E-11 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.108 3.27E-10 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.107 5.63E-10 YHR022C_p YHR022C_p hom Putative protein of unknown function; YHR022C is not an essential gene
0.107 5.69E-10 YPL100W ATG21 hom Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
0.105 1.25E-9 YDR513W GRX2 hom Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication
0.104 1.59E-9 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.101 4.42E-9 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.101 4.60E-9 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.098 1.12E-8 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
0.098 1.19E-8 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.097 2.16E-8 YAL004W_d YAL004W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C