HIPHOP chemogenomics database

YHR066W / SSF1

Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR066W / SSF1

Click on Significant Values for Screen Details

Top fitness defect scores for YHR066W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2636	apigenin dimethyl ether	10.30	100.0 µM	1.34E-24		4	3.79E-25
2	SGTC_2688	kanamycin b	4.82	96.7 µM	7.73E-7	calcium & mitochondrial duress	262	7.02E-7
3	SGTC_1483	3453-0561	4.54	55.9 µM	3.00E-6		12	2.81E-6
4	SGTC_3166	9102297	4.31	49.5 µM	8.36E-6	Golgi	27	8.01E-6
5	SGTC_118	0083-0097	4.28	135.3 µM	9.91E-6	translation	103	9.53E-6
6	SGTC_89	0302-0250	3.95	142.1 µM	3.96E-5		19	3.91E-5
7	SGTC_1031	k035-0009	3.87	16.0 µM	5.41E-5		34	5.39E-5
8	SGTC_1733	st037357	3.84	54.9 µM	6.22E-5	60S ribosome export	33	6.21E-5
9	SGTC_2320	7373003	3.75	200.0 µM	8.66E-5		32	8.70E-5
10	SGTC_1737	st035557	3.69	69.7 µM	1.10E-4		20	1.11E-4
11	SGTC_1944	st076371	3.65	56.9 µM	1.27E-4		28	1.29E-4
12	SGTC_1960	st011366	3.59	51.8 µM	1.60E-4		19	1.62E-4
13	SGTC_2634	4'-methoxyflavone	3.58	100.0 µM	1.69E-4		44	1.72E-4
14	SGTC_167	3672-0051	3.51	66.2 µM	2.18E-4		55	2.22E-4
15	SGTC_1173	0443-0020	3.49	122.0 µM	2.39E-4	TSC3-RPN4	59	2.44E-4
16	SGTC_3164	9100705	3.47	49.5 µM	2.57E-4		11	2.64E-4
17	SGTC_2730	imipramine	3.45	71.3 µM	2.76E-4		43	2.83E-4
18	SGTC_1719	st032227	3.43	49.2 µM	2.92E-4		40	3.00E-4
19	SGTC_581	0958-0271	3.42	211.0 µM	3.00E-4		75	3.08E-4
20	SGTC_26	0302-0163	3.33	425.2 µM	4.14E-4	heme biosynthesis & mitochondrial translocase	23	4.27E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.144	5.97E-17	YPR044C_d	OPI11_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO
0.131	2.59E-14	YDL082W	RPL13A	hom	Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.122	1.15E-12	YEL054C	RPL12A	hom	Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.107	4.93E-10	YDR395W	SXM1	hom	Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
0.104	1.31E-9	YPL249C-A	RPL36B	hom	Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.103	2.42E-9	YMR230W	RPS10B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication
0.102	2.98E-9	YLR061W	RPL22A	hom	Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.102	3.22E-9	YML073C	RPL6A	hom	Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.101	4.10E-9	YDL081C	RPP1A	hom	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.101	5.20E-9	YGR085C	RPL11B	hom	Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.099	8.22E-9	YHL033C	RPL8A	hom	Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.098	1.52E-8	YPL255W	BBP1	het	Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
0.097	1.74E-8	YBR191W	RPL21A	hom	Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.096	2.62E-8	YIR031C	DAL7	hom	Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.095	3.87E-8	YDR447C	RPS17B	hom	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress