YHR066W / SSF1

Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR066W / SSF1

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.33|P-value:4.14E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.95|P-value:3.96E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.28|P-value:9.91E-6 ID:SGTC_162|Compound:k030-0015|FD-Score:-4.21|P-value:2.42E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:3.51|P-value:2.18E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.55|P-value:3.19E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-5.53|P-value:4.22E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.32|P-value:1.51E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.63|P-value:2.41E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.42|P-value:3.00E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-3.94|P-value:7.36E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.49|P-value:7.44E-6 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.87|P-value:5.41E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.49|P-value:2.39E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.20|P-value:6.71E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.16|P-value:7.54E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.20|P-value:6.56E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.19|P-value:6.89E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.54|P-value:3.00E-6 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.14|P-value:8.12E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.21|P-value:6.38E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.76|P-value:1.48E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.77|P-value:1.46E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.43|P-value:2.92E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.84|P-value:6.22E-5 ID:SGTC_1737|Compound:st035557|FD-Score:3.69|P-value:1.10E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.32|P-value:4.35E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.65|P-value:1.27E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.59|P-value:1.60E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-3.27|P-value:8.53E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.13|P-value:8.25E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.75|P-value:8.66E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.65|P-value:2.27E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.19|P-value:6.90E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.58|P-value:1.69E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:10.30|P-value:1.34E-24 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.82|P-value:7.73E-7 ID:SGTC_2730|Compound:imipramine|FD-Score:3.45|P-value:2.76E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-4.01|P-value:5.67E-5 ID:SGTC_2905|Compound:7799065|FD-Score:-3.54|P-value:3.41E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.23|P-value:9.72E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.47|P-value:2.57E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.31|P-value:8.36E-6 ID:SGTC_3339|Compound:9145883|FD-Score:-3.33|P-value:7.02E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.33|P-value:4.14E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.95|P-value:3.96E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.28|P-value:9.91E-6 ID:SGTC_162|Compound:k030-0015|FD-Score:-4.21|P-value:2.42E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:3.51|P-value:2.18E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.55|P-value:3.19E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-5.53|P-value:4.22E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.32|P-value:1.51E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.63|P-value:2.41E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.42|P-value:3.00E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-3.94|P-value:7.36E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.49|P-value:7.44E-6 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.87|P-value:5.41E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.49|P-value:2.39E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.20|P-value:6.71E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.16|P-value:7.54E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.20|P-value:6.56E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.19|P-value:6.89E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.54|P-value:3.00E-6 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.14|P-value:8.12E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.21|P-value:6.38E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.76|P-value:1.48E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.77|P-value:1.46E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.43|P-value:2.92E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.84|P-value:6.22E-5 ID:SGTC_1737|Compound:st035557|FD-Score:3.69|P-value:1.10E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.32|P-value:4.35E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.65|P-value:1.27E-4 ID:SGTC_1960|Compound:st011366|FD-Score:3.59|P-value:1.60E-4 ID:SGTC_2074|Compound:5212007|FD-Score:-3.27|P-value:8.53E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.13|P-value:8.25E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.75|P-value:8.66E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.65|P-value:2.27E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.19|P-value:6.90E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.58|P-value:1.69E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:10.30|P-value:1.34E-24 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.82|P-value:7.73E-7 ID:SGTC_2730|Compound:imipramine|FD-Score:3.45|P-value:2.76E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-4.01|P-value:5.67E-5 ID:SGTC_2905|Compound:7799065|FD-Score:-3.54|P-value:3.41E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-3.23|P-value:9.72E-4 ID:SGTC_3164|Compound:9100705|FD-Score:3.47|P-value:2.57E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.31|P-value:8.36E-6 ID:SGTC_3339|Compound:9145883|FD-Score:-3.33|P-value:7.02E-4

Top fitness defect scores for YHR066W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2636 apigenin dimethyl ether 10.30 100.0 µM 1.34E-24 4 3.79E-25
2 SGTC_2688 kanamycin b 4.82 96.7 µM 7.73E-7 calcium & mitochondrial duress 262 7.02E-7
3 SGTC_1483 3453-0561 4.54 55.9 µM 3.00E-6 12 2.81E-6
4 SGTC_3166 9102297 4.31 49.5 µM 8.36E-6 Golgi 27 8.01E-6
5 SGTC_118 0083-0097 4.28 135.3 µM 9.91E-6 translation 103 9.53E-6
6 SGTC_89 0302-0250 3.95 142.1 µM 3.96E-5 19 3.91E-5
7 SGTC_1031 k035-0009 3.87 16.0 µM 5.41E-5 34 5.39E-5
8 SGTC_1733 st037357 3.84 54.9 µM 6.22E-5 60S ribosome export 33 6.21E-5
9 SGTC_2320 7373003 3.75 200.0 µM 8.66E-5 32 8.70E-5
10 SGTC_1737 st035557 3.69 69.7 µM 1.10E-4 20 1.11E-4
11 SGTC_1944 st076371 3.65 56.9 µM 1.27E-4 28 1.29E-4
12 SGTC_1960 st011366 3.59 51.8 µM 1.60E-4 19 1.62E-4
13 SGTC_2634 4'-methoxyflavone 3.58 100.0 µM 1.69E-4 44 1.72E-4
14 SGTC_167 3672-0051 3.51 66.2 µM 2.18E-4 55 2.22E-4
15 SGTC_1173 0443-0020 3.49 122.0 µM 2.39E-4 TSC3-RPN4 59 2.44E-4
16 SGTC_3164 9100705 3.47 49.5 µM 2.57E-4 11 2.64E-4
17 SGTC_2730 imipramine 3.45 71.3 µM 2.76E-4 43 2.83E-4
18 SGTC_1719 st032227 3.43 49.2 µM 2.92E-4 40 3.00E-4
19 SGTC_581 0958-0271 3.42 211.0 µM 3.00E-4 75 3.08E-4
20 SGTC_26 0302-0163 3.33 425.2 µM 4.14E-4 heme biosynthesis & mitochondrial translocase 23 4.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.97E-17 YPR044C_d OPI11_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO
0.131 2.59E-14 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.122 1.15E-12 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.107 4.93E-10 YDR395W SXM1 hom Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
0.104 1.31E-9 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication
0.103 2.42E-9 YMR230W RPS10B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication
0.102 2.98E-9 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.102 3.22E-9 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.101 4.10E-9 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.101 5.20E-9 YGR085C RPL11B hom Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.099 8.22E-9 YHL033C RPL8A hom Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.098 1.52E-8 YPL255W BBP1 het Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
0.097 1.74E-8 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.096 2.62E-8 YIR031C DAL7 hom Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.095 3.87E-8 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress