HIPHOP chemogenomics database

YHR092C / HXT4

High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR092C / HXT4

Click on Significant Values for Screen Details

Top fitness defect scores for YHR092C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2582	agaric acid	8.63	100.0 µM	2.80E-20	redox potentiating	93	3.04E-18
2	SGTC_2009	4012297	5.43	12.1 µM	3.43E-9	cell wall signaling	29	2.84E-8
3	SGTC_2798	7813637	5.41	45.5 µM	3.75E-9		7	3.07E-8
4	SGTC_2802	7925815	4.92	54.5 µM	7.12E-8		20	4.30E-7
5	SGTC_2248	tofa	4.83	1.1 µM	1.21E-7	sphingolipid biosynthesis & PDR1	29	6.95E-7
6	SGTC_58	0957-0393	4.77	9.0 µM	1.69E-7	cell wall	310	9.32E-7
7	SGTC_2602	kawain	4.68	100.0 µM	2.76E-7		12	1.45E-6
8	SGTC_2633	5,7-dihydroxyisoflavone	4.50	100.0 µM	7.17E-7		23	3.40E-6
9	SGTC_607	4491-0986	4.45	66.8 µM	9.40E-7	heme requiring	16	4.34E-6
10	SGTC_2658	polymyxin b sulfate	4.30	77.0 µM	2.04E-6	NEO1	33	8.69E-6
11	SGTC_2821	7996764	4.27	71.4 µM	2.31E-6		28	9.70E-6
12	SGTC_2450	5739737	4.25	12.9 µM	2.58E-6		19	1.07E-5
13	SGTC_3157	9099274	4.21	49.5 µM	3.15E-6		15	1.28E-5
14	SGTC_405	ebelactone b	4.16	50.0 µM	4.09E-6		14	1.62E-5
15	SGTC_2355	9061122	4.09	103.1 µM	5.65E-6		11	2.16E-5
16	SGTC_1408	3909-7976	3.87	48.8 µM	1.60E-5	Golgi	22	5.48E-5
17	SGTC_1435	4092-0789	3.68	56.7 µM	3.69E-5	plasma membrane duress	18	1.16E-4
18	SGTC_1224	0823-0416	3.67	294.0 µM	3.82E-5		16	1.19E-4
19	SGTC_1794	st048918	3.54	76.9 µM	6.95E-5		14	2.03E-4
20	SGTC_180	1486-1293	3.46	102.8 µM	9.58E-5		53	2.70E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.253	3.53E-50	YML103C	NUP188	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.230	2.22E-41	YGL178W	MPT5	hom	mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.224	2.14E-39	YNL106C	INP52	hom	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.203	2.04E-32	YMR109W	MYO5	hom	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.195	4.06E-30	YEL007W	MIT1	hom	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.189	2.34E-28	YNL105W_d	RRT16_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.188	4.00E-28	YNL027W	CRZ1	hom	Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.184	5.97E-27	YNL074C	MLF3	hom	Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.184	7.25E-27	YHR036W	BRL1	het	Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.183	9.90E-27	YGR196C	FYV8	hom	Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.181	4.57E-26	YOR049C	RSB1	hom	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.180	8.56E-26	YBR082C	UBC4	hom	Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.180	9.97E-26	YOR231W	MKK1	hom	MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.176	9.31E-25	YBR260C	RGD1	hom	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.175	1.89E-24	YML052W	SUR7	hom	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants