YHR095W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR095W / YHR095W

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.27|P-value:4.83E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.09|P-value:9.18E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.81|P-value:6.19E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:3.96|P-value:3.21E-5 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.68|P-value:1.00E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.12|P-value:1.65E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.40|P-value:2.94E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.97|P-value:3.15E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:-3.49|P-value:2.10E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.25|P-value:5.29E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:4.07|P-value:2.07E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.35|P-value:3.66E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.43|P-value:2.72E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.78|P-value:6.91E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.42|P-value:2.83E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.36|P-value:3.50E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:5.29|P-value:4.65E-8 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.17|P-value:6.83E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:5.67|P-value:5.27E-9 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.41|P-value:2.98E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.08|P-value:9.53E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.17|P-value:6.62E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.45|P-value:2.56E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.18|P-value:6.76E-4 ID:SGTC_2082|Compound:5219693|FD-Score:4.18|P-value:1.24E-5 ID:SGTC_2118|Compound:5526350|FD-Score:3.29|P-value:4.57E-4 ID:SGTC_2121|Compound:5257820|FD-Score:5.48|P-value:1.66E-8 ID:SGTC_2158|Compound:5657123|FD-Score:3.55|P-value:1.72E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.74|P-value:8.61E-7 ID:SGTC_2242|Compound:6630449|FD-Score:-3.71|P-value:8.88E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.31|P-value:4.35E-8 ID:SGTC_2712|Compound:st079126|FD-Score:-3.91|P-value:3.84E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.53|P-value:1.87E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.47|P-value:2.34E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.21|P-value:6.03E-4 ID:SGTC_3129|Compound:9127257|FD-Score:5.57|P-value:9.41E-9 ID:SGTC_3149|Compound:9097855|FD-Score:4.20|P-value:1.14E-5 ID:SGTC_3157|Compound:9099274|FD-Score:4.19|P-value:1.19E-5 ID:SGTC_3158|Compound:9100007|FD-Score:4.01|P-value:2.64E-5 ID:SGTC_4|Compound:0960-0234|FD-Score:3.27|P-value:4.83E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.09|P-value:9.18E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.81|P-value:6.19E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:3.96|P-value:3.21E-5 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.68|P-value:1.00E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.12|P-value:1.65E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.40|P-value:2.94E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.97|P-value:3.15E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:-3.49|P-value:2.10E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.25|P-value:5.29E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:4.07|P-value:2.07E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.35|P-value:3.66E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.43|P-value:2.72E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.78|P-value:6.91E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.42|P-value:2.83E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.36|P-value:3.50E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:5.29|P-value:4.65E-8 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.17|P-value:6.83E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:5.67|P-value:5.27E-9 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.41|P-value:2.98E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.08|P-value:9.53E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-3.17|P-value:6.62E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.45|P-value:2.56E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.18|P-value:6.76E-4 ID:SGTC_2082|Compound:5219693|FD-Score:4.18|P-value:1.24E-5 ID:SGTC_2118|Compound:5526350|FD-Score:3.29|P-value:4.57E-4 ID:SGTC_2121|Compound:5257820|FD-Score:5.48|P-value:1.66E-8 ID:SGTC_2158|Compound:5657123|FD-Score:3.55|P-value:1.72E-4 ID:SGTC_2174|Compound:5790901|FD-Score:4.74|P-value:8.61E-7 ID:SGTC_2242|Compound:6630449|FD-Score:-3.71|P-value:8.88E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.31|P-value:4.35E-8 ID:SGTC_2712|Compound:st079126|FD-Score:-3.91|P-value:3.84E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.53|P-value:1.87E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.47|P-value:2.34E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.21|P-value:6.03E-4 ID:SGTC_3129|Compound:9127257|FD-Score:5.57|P-value:9.41E-9 ID:SGTC_3149|Compound:9097855|FD-Score:4.20|P-value:1.14E-5 ID:SGTC_3157|Compound:9099274|FD-Score:4.19|P-value:1.19E-5 ID:SGTC_3158|Compound:9100007|FD-Score:4.01|P-value:2.64E-5

Top fitness defect scores for YHR095W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1164 k060-0068 5.67 93.7 µM 5.27E-9 6 7.01E-9
2 SGTC_3129 9127257 5.57 49.5 µM 9.41E-9 5 1.24E-8
3 SGTC_2121 5257820 5.48 149.6 µM 1.66E-8 1 2.16E-8
4 SGTC_2639 lactacystin 5.31 53.0 µM 4.35E-8 9 5.57E-8
5 SGTC_975 1335-0046 5.29 28.5 µM 4.65E-8 RPP1 & pyrimidine depletion 13 5.95E-8
6 SGTC_2174 5790901 4.74 200.0 µM 8.61E-7 tubulin folding & SWR complex 25 1.05E-6
7 SGTC_3149 9097855 4.20 49.5 µM 1.14E-5 Golgi 21 1.32E-5
8 SGTC_3157 9099274 4.19 49.5 µM 1.19E-5 16 1.38E-5
9 SGTC_2082 5219693 4.18 150.0 µM 1.24E-5 RNA processing & uracil transport 24 1.44E-5
10 SGTC_95 0471-0001 4.12 561.1 µM 1.65E-5 21 1.92E-5
11 SGTC_369 0957-0393 4.07 4.5 µM 2.07E-5 cell wall signaling 21 2.39E-5
12 SGTC_3158 9100007 4.01 49.5 µM 2.64E-5 18 3.03E-5
13 SGTC_158 k038-0087 3.97 26.4 µM 3.15E-5 ubiquinone biosynthesis & proteasome 136 3.60E-5
14 SGTC_42 0133-0086 3.96 60.6 µM 3.21E-5 32 3.67E-5
15 SGTC_39 0986-0283 3.81 58.4 µM 6.19E-5 calcium & mitochondrial duress 39 7.01E-5
16 SGTC_600 1495-0418 3.78 41.6 µM 6.91E-5 RPP1 & pyrimidine depletion 14 7.81E-5
17 SGTC_2158 5657123 3.55 3.6 µM 1.72E-4 11 1.92E-4
18 SGTC_2935 9038016 3.53 30.0 µM 1.87E-4 26 2.08E-4
19 SGTC_2976 9009005 3.47 19.5 µM 2.34E-4 39 2.59E-4
20 SGTC_1924 st058459 3.45 75.1 µM 2.56E-4 20 2.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.76E-9 YOR288C MPD1 hom Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
0.100 7.14E-9 YJR004C SAG1 hom Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
0.096 2.35E-8 YJL197W UBP12 hom Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm
0.093 7.03E-8 YIL119C RPI1 hom Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF
0.092 9.72E-8 YPL163C SVS1 hom Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication
0.090 1.53E-7 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.086 6.82E-7 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
0.085 7.66E-7 YDL141W BPL1 het Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
0.085 9.35E-7 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.084 1.18E-6 YOR344C TYE7 hom Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
0.083 1.88E-6 YML079W_p YML079W_p hom Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm
0.081 2.41E-6 YBL098W BNA4 hom Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
0.081 2.76E-6 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
0.080 3.20E-6 YAR047C_d YAR047C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.078 5.48E-6 YJL213W YJL213W hom Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p