YHR117W / TOM71

Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR117W / TOM71

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:-3.31|P-value:1.67E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:-3.98|P-value:8.13E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:3.32|P-value:1.80E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.18|P-value:3.20E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.93|P-value:5.76E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:3.25|P-value:2.45E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.90|P-value:1.20E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:3.60|P-value:5.40E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-2.91|P-value:7.96E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.87|P-value:7.95E-8 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.42|P-value:1.22E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-2.87|P-value:9.20E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.45|P-value:1.07E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.05|P-value:6.74E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:9.15|P-value:3.45E-23 ID:SGTC_779|Compound:1360-0071|FD-Score:3.63|P-value:4.78E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.19|P-value:3.04E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.63|P-value:4.27E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:2.91|P-value:9.08E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.46|P-value:1.02E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.66|P-value:2.66E-7 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.18|P-value:3.18E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.19|P-value:2.71E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.66|P-value:4.28E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.32|P-value:1.81E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:-2.94|P-value:7.05E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:2.98|P-value:6.87E-4 ID:SGTC_1738|Compound:st035555|FD-Score:2.91|P-value:9.03E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.19|P-value:1.18E-8 ID:SGTC_1763|Compound:st044482|FD-Score:3.48|P-value:9.34E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.37|P-value:1.45E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.77|P-value:2.51E-5 ID:SGTC_1969|Compound:st069479|FD-Score:3.27|P-value:2.20E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.43|P-value:1.14E-4 ID:SGTC_2060|Compound:5238662|FD-Score:5.90|P-value:1.06E-10 ID:SGTC_2301|Compound:7769476|FD-Score:-3.11|P-value:3.73E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.30|P-value:2.00E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.60|P-value:5.63E-5 ID:SGTC_2429|Compound:5902844|FD-Score:-4.48|P-value:6.23E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.69|P-value:3.17E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.49|P-value:7.84E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:2.97|P-value:7.27E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.20|P-value:2.94E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:2.92|P-value:8.60E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.05|P-value:4.82E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.03|P-value:5.07E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.62|P-value:3.31E-7 ID:SGTC_3026|Compound:9090633|FD-Score:5.30|P-value:5.92E-9 ID:SGTC_3030|Compound:9087619|FD-Score:3.55|P-value:6.73E-5 ID:SGTC_3315|Compound:9136395|FD-Score:-3.56|P-value:5.79E-5 ID:SGTC_1|Compound:0258-0098|FD-Score:-3.31|P-value:1.67E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:-3.98|P-value:8.13E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:3.32|P-value:1.80E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.18|P-value:3.20E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.93|P-value:5.76E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:3.25|P-value:2.45E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.90|P-value:1.20E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:3.60|P-value:5.40E-5 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-2.91|P-value:7.96E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.87|P-value:7.95E-8 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.42|P-value:1.22E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-2.87|P-value:9.20E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.45|P-value:1.07E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:4.05|P-value:6.74E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:9.15|P-value:3.45E-23 ID:SGTC_779|Compound:1360-0071|FD-Score:3.63|P-value:4.78E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.19|P-value:3.04E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.63|P-value:4.27E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:2.91|P-value:9.08E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.46|P-value:1.02E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.66|P-value:2.66E-7 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.18|P-value:3.18E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.19|P-value:2.71E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.66|P-value:4.28E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.32|P-value:1.81E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:-2.94|P-value:7.05E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:2.98|P-value:6.87E-4 ID:SGTC_1738|Compound:st035555|FD-Score:2.91|P-value:9.03E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.19|P-value:1.18E-8 ID:SGTC_1763|Compound:st044482|FD-Score:3.48|P-value:9.34E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.37|P-value:1.45E-4 ID:SGTC_1818|Compound:st052136|FD-Score:3.77|P-value:2.51E-5 ID:SGTC_1969|Compound:st069479|FD-Score:3.27|P-value:2.20E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.43|P-value:1.14E-4 ID:SGTC_2060|Compound:5238662|FD-Score:5.90|P-value:1.06E-10 ID:SGTC_2301|Compound:7769476|FD-Score:-3.11|P-value:3.73E-4 ID:SGTC_2312|Compound:7706453|FD-Score:3.30|P-value:2.00E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.60|P-value:5.63E-5 ID:SGTC_2429|Compound:5902844|FD-Score:-4.48|P-value:6.23E-7 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.69|P-value:3.17E-5 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.49|P-value:7.84E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:2.97|P-value:7.27E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.20|P-value:2.94E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:2.92|P-value:8.60E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.05|P-value:4.82E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.03|P-value:5.07E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.62|P-value:3.31E-7 ID:SGTC_3026|Compound:9090633|FD-Score:5.30|P-value:5.92E-9 ID:SGTC_3030|Compound:9087619|FD-Score:3.55|P-value:6.73E-5 ID:SGTC_3315|Compound:9136395|FD-Score:-3.56|P-value:5.79E-5

Top fitness defect scores for YHR117W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_774 k060-0086 9.15 136.0 µM 3.45E-23 2 2.94E-20
2 SGTC_2060 5238662 5.90 140.0 µM 1.06E-10 6 1.77E-9
3 SGTC_3026 9090633 5.30 49.5 µM 5.92E-9 5 5.74E-8
4 SGTC_1754 st042065 5.19 16.1 µM 1.18E-8 NEO1-PIK1 117 1.04E-7
5 SGTC_103 0844-0104 4.93 51.8 µM 5.76E-8 ERAD & cell cycle 104 4.12E-7
6 SGTC_436 n,n-dimethylsphingosine 4.87 3.3 µM 7.95E-8 13 5.44E-7
7 SGTC_1136 pergolide 4.66 1.1 µM 2.66E-7 22 1.55E-6
8 SGTC_2776 terbinafine 4.62 19.9 µM 3.31E-7 cell wall signaling 39 1.88E-6
9 SGTC_605 1315-0399 4.05 119.0 µM 6.74E-6 Golgi 20 2.56E-5
10 SGTC_1818 st052136 3.77 56.3 µM 2.51E-5 NEO1-PIK1 61 8.03E-5
11 SGTC_1407 3909-7909 3.66 12.3 µM 4.28E-5 60S ribosome export 20 1.28E-4
12 SGTC_779 1360-0071 3.63 233.0 µM 4.78E-5 fatty acid desaturase (OLE1) 41 1.41E-4
13 SGTC_169 k015-0017 3.60 16.0 µM 5.40E-5 30 1.56E-4
14 SGTC_2318 6029776 3.60 164.0 µM 5.63E-5 40 1.62E-4
15 SGTC_3030 9087619 3.55 49.5 µM 6.73E-5 20 1.89E-4
16 SGTC_1763 st044482 3.48 94.5 µM 9.34E-5 copper-dependent oxidative stress 31 2.52E-4
17 SGTC_986 1493-0483 3.46 84.0 µM 1.02E-4 25 2.72E-4
18 SGTC_580 1123-0028 3.45 41.0 µM 1.07E-4 DNA damage response 56 2.84E-4
19 SGTC_2041 5107442 3.43 45.3 µM 1.14E-4 RSC complex & mRNA processing 41 2.99E-4
20 SGTC_445 e6 berbamine 3.42 66.0 µM 1.22E-4 NEO1-PIK1 152 3.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 5.24E-15 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication
0.127 1.80E-13 YDR453C TSA2 hom Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress
0.124 5.11E-13 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.119 4.87E-12 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.118 7.86E-12 YBL075C SSA3 hom ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication
0.117 1.28E-11 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.109 2.82E-10 YLR257W YLR257W hom Protein of unknown function; protein abundance increases in response to DNA replication stress
0.107 4.21E-10 YBR059C AKL1 hom Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization
0.103 1.90E-9 YGR175C ERG1 het Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
0.103 1.90E-9 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.102 3.59E-9 YLL058W_p YLL058W_p hom Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene
0.099 9.41E-9 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.094 5.31E-8 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.093 5.80E-8 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.093 7.16E-8 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin