YHR120W / MSH1

DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR120W / MSH1

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.50|P-value:3.71E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.50|P-value:3.64E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.24|P-value:4.82E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.87|P-value:9.90E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:5.84|P-value:1.23E-8 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.69|P-value:3.54E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.57|P-value:1.29E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:10.50|P-value:9.32E-24 ID:SGTC_236|Compound:1509-0011|FD-Score:7.47|P-value:6.01E-13 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.84|P-value:1.77E-6 ID:SGTC_283|Compound:0987-0079|FD-Score:3.65|P-value:2.17E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:10.20|P-value:1.38E-22 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.64|P-value:4.23E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.27|P-value:7.93E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.57|P-value:5.40E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.55|P-value:3.13E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.49|P-value:6.96E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.27|P-value:7.87E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.60|P-value:2.59E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.68|P-value:1.98E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.26|P-value:8.18E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.55|P-value:3.09E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:5.71|P-value:2.48E-8 ID:SGTC_717|Compound:1532-0246|FD-Score:4.05|P-value:4.89E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.67|P-value:8.28E-6 ID:SGTC_763|Compound:3453-1109|FD-Score:3.20|P-value:9.88E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.88|P-value:9.52E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.34|P-value:6.22E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.46|P-value:9.46E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:3.54|P-value:3.17E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.67|P-value:2.06E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.82|P-value:1.17E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.28|P-value:7.66E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:6.11|P-value:2.72E-9 ID:SGTC_1108|Compound:betulinic acid|FD-Score:5.53|P-value:6.31E-8 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.45|P-value:7.79E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.95|P-value:1.44E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-5.15|P-value:9.71E-7 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.89|P-value:1.73E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.77|P-value:1.42E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:4.99|P-value:8.75E-7 ID:SGTC_1695|Compound:st026914|FD-Score:3.35|P-value:6.11E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.37|P-value:2.90E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.75|P-value:5.10E-8 ID:SGTC_1742|Compound:st038235|FD-Score:5.87|P-value:1.04E-8 ID:SGTC_1891|Compound:st059073|FD-Score:3.47|P-value:4.08E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.42|P-value:4.80E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.55|P-value:6.42E-6 ID:SGTC_1913|Compound:st060213|FD-Score:4.46|P-value:9.42E-6 ID:SGTC_1921|Compound:5740136|FD-Score:3.99|P-value:6.20E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.76|P-value:1.46E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.08|P-value:7.92E-12 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.70|P-value:3.48E-4 ID:SGTC_2296|Compound:7971656|FD-Score:5.91|P-value:8.33E-9 ID:SGTC_2309|Compound:7664088|FD-Score:5.76|P-value:1.93E-8 ID:SGTC_2311|Compound:7694451|FD-Score:3.67|P-value:2.07E-4 ID:SGTC_2313|Compound:7726885|FD-Score:5.33|P-value:1.77E-7 ID:SGTC_2526|Compound:patulin|FD-Score:4.51|P-value:7.55E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.52|P-value:3.45E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.16|P-value:3.27E-5 ID:SGTC_2705|Compound:st078069|FD-Score:5.49|P-value:7.76E-8 ID:SGTC_2837|Compound:9008476|FD-Score:-3.79|P-value:2.53E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.60|P-value:5.17E-6 ID:SGTC_2944|Compound:9067346|FD-Score:3.85|P-value:1.06E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.22|P-value:2.53E-5 ID:SGTC_3291|Compound:9121177|FD-Score:3.66|P-value:2.08E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.50|P-value:3.71E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.50|P-value:3.64E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.24|P-value:4.82E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.87|P-value:9.90E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:3.62|P-value:2.45E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:5.84|P-value:1.23E-8 ID:SGTC_94|Compound:0334-0113|FD-Score:-3.69|P-value:3.54E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.57|P-value:1.29E-7 ID:SGTC_173|Compound:1273-0061|FD-Score:10.50|P-value:9.32E-24 ID:SGTC_236|Compound:1509-0011|FD-Score:7.47|P-value:6.01E-13 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.84|P-value:1.77E-6 ID:SGTC_283|Compound:0987-0079|FD-Score:3.65|P-value:2.17E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:10.20|P-value:1.38E-22 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.64|P-value:4.23E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.27|P-value:7.93E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.57|P-value:5.40E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.55|P-value:3.13E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.49|P-value:6.96E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.27|P-value:7.87E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.60|P-value:2.59E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.68|P-value:1.98E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.26|P-value:8.18E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.55|P-value:3.09E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:5.71|P-value:2.48E-8 ID:SGTC_717|Compound:1532-0246|FD-Score:4.05|P-value:4.89E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.67|P-value:8.28E-6 ID:SGTC_763|Compound:3453-1109|FD-Score:3.20|P-value:9.88E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.88|P-value:9.52E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.34|P-value:6.22E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.46|P-value:9.46E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:3.54|P-value:3.17E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.67|P-value:2.06E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.82|P-value:1.17E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.28|P-value:7.66E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:6.11|P-value:2.72E-9 ID:SGTC_1108|Compound:betulinic acid|FD-Score:5.53|P-value:6.31E-8 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.45|P-value:7.79E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.95|P-value:1.44E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-5.15|P-value:9.71E-7 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.89|P-value:1.73E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.77|P-value:1.42E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:4.99|P-value:8.75E-7 ID:SGTC_1695|Compound:st026914|FD-Score:3.35|P-value:6.11E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.37|P-value:2.90E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.75|P-value:5.10E-8 ID:SGTC_1742|Compound:st038235|FD-Score:5.87|P-value:1.04E-8 ID:SGTC_1891|Compound:st059073|FD-Score:3.47|P-value:4.08E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.42|P-value:4.80E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.55|P-value:6.42E-6 ID:SGTC_1913|Compound:st060213|FD-Score:4.46|P-value:9.42E-6 ID:SGTC_1921|Compound:5740136|FD-Score:3.99|P-value:6.20E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.76|P-value:1.46E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.08|P-value:7.92E-12 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.70|P-value:3.48E-4 ID:SGTC_2296|Compound:7971656|FD-Score:5.91|P-value:8.33E-9 ID:SGTC_2309|Compound:7664088|FD-Score:5.76|P-value:1.93E-8 ID:SGTC_2311|Compound:7694451|FD-Score:3.67|P-value:2.07E-4 ID:SGTC_2313|Compound:7726885|FD-Score:5.33|P-value:1.77E-7 ID:SGTC_2526|Compound:patulin|FD-Score:4.51|P-value:7.55E-6 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.52|P-value:3.45E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.16|P-value:3.27E-5 ID:SGTC_2705|Compound:st078069|FD-Score:5.49|P-value:7.76E-8 ID:SGTC_2837|Compound:9008476|FD-Score:-3.79|P-value:2.53E-4 ID:SGTC_2845|Compound:9003024|FD-Score:4.60|P-value:5.17E-6 ID:SGTC_2944|Compound:9067346|FD-Score:3.85|P-value:1.06E-4 ID:SGTC_3283|Compound:9109332|FD-Score:4.22|P-value:2.53E-5 ID:SGTC_3291|Compound:9121177|FD-Score:3.66|P-value:2.08E-4

Top fitness defect scores for YHR120W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 10.50 2.7 µM 9.32E-24 mitochondrial stress 36 3.35E-26
2 SGTC_310 1273-0058 10.20 1.1 µM 1.38E-22 mitochondrial stress 39 6.86E-25
3 SGTC_236 1509-0011 7.47 5.3 µM 6.01E-13 259 4.11E-14
4 SGTC_2250 alverine citrate 7.08 130.0 µM 7.92E-12 34 7.30E-13
5 SGTC_1107 amlodipine 6.11 47.0 µM 2.72E-9 4 4.86E-10
6 SGTC_2296 7971656 5.91 126.5 µM 8.33E-9 13 1.69E-9
7 SGTC_1742 st038235 5.87 28.9 µM 1.04E-8 mitochondrial stress 49 2.16E-9
8 SGTC_70 0141-0289 5.84 43.3 µM 1.23E-8 mitochondrial stress 85 2.61E-9
9 SGTC_2309 7664088 5.76 163.9 µM 1.93E-8 6 4.28E-9
10 SGTC_697 0508-1955 5.71 564.0 µM 2.48E-8 6 5.67E-9
11 SGTC_1108 betulinic acid 5.53 729.1 nM 6.31E-8 2 1.60E-8
12 SGTC_2705 st078069 5.49 42.8 µM 7.76E-8 1 2.01E-8
13 SGTC_2313 7726885 5.33 200.0 µM 1.77E-7 RPP1 & pyrimidine depletion 12 5.03E-8
14 SGTC_1462 k081-0014 4.99 26.5 µM 8.75E-7 5 2.95E-7
15 SGTC_275 trichlorophene 4.84 5.7 µM 1.77E-6 mitochondrial stress 178 6.42E-7
16 SGTC_2845 9003024 4.60 43.0 µM 5.17E-6 amide catabolism 28 2.11E-6
17 SGTC_1911 st060208 4.55 74.3 µM 6.42E-6 21 2.68E-6
18 SGTC_2526 patulin 4.51 37.6 µM 7.55E-6 62 3.21E-6
19 SGTC_1913 st060213 4.46 96.1 µM 9.42E-6 17 4.09E-6
20 SGTC_832 4083-0019 4.46 164.0 µM 9.46E-6 translation 62 4.11E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.399 2.06E-128 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.390 7.71E-122 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.388 4.71E-121 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.387 2.15E-120 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.384 4.09E-118 YLR149C YLR149C hom Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.375 2.04E-112 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.374 7.06E-112 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.374 1.91E-111 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.372 9.02E-111 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.370 1.19E-109 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.370 2.91E-109 YIL070C MAM33 hom Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
0.366 3.66E-107 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.366 5.65E-107 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.365 1.28E-106 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.364 7.27E-106 YNL284C MRPL10 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels