YHR135C / YCK1

Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR135C / YCK1

Click on Significant Values for Screen Details ID:SGTC_88|Compound:0180-0332|FD-Score:-3.53|P-value:1.59E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.16|P-value:6.41E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:-3.22|P-value:5.19E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.22|P-value:5.10E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.70|P-value:8.19E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.03|P-value:9.96E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.40|P-value:2.58E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:-4.18|P-value:1.01E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.83|P-value:4.84E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.35|P-value:3.12E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.65|P-value:1.01E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.49|P-value:2.26E-6 ID:SGTC_1199|Compound:1638-0010|FD-Score:-3.67|P-value:9.11E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.68|P-value:8.53E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.08|P-value:8.24E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.13|P-value:7.08E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.29|P-value:5.93E-6 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.41|P-value:2.53E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.41|P-value:3.41E-6 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.74|P-value:6.66E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.69|P-value:8.18E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.29|P-value:6.10E-6 ID:SGTC_1637|Compound:st007924|FD-Score:4.77|P-value:5.73E-7 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.25|P-value:4.57E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.91|P-value:3.32E-5 ID:SGTC_1923|Compound:st058458|FD-Score:3.33|P-value:3.37E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.29|P-value:3.93E-4 ID:SGTC_2030|Compound:5175110|FD-Score:-3.59|P-value:1.28E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-3.32|P-value:3.53E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.36|P-value:2.99E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.31|P-value:3.68E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.89|P-value:3.07E-7 ID:SGTC_2421|Compound:5690543|FD-Score:3.68|P-value:8.53E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-4.05|P-value:1.80E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.12|P-value:7.19E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.79|P-value:5.61E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.04|P-value:9.58E-4 ID:SGTC_2892|Compound:9047358|FD-Score:-3.38|P-value:2.83E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.18|P-value:5.79E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.79|P-value:5.59E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.08|P-value:8.21E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.25|P-value:4.57E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.24|P-value:4.74E-4 ID:SGTC_3238|Compound:9133470|FD-Score:4.52|P-value:1.99E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:-3.53|P-value:1.59E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.16|P-value:6.41E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:-3.22|P-value:5.19E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.22|P-value:5.10E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.70|P-value:8.19E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.03|P-value:9.96E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:3.40|P-value:2.58E-4 ID:SGTC_693|Compound:4161-2696|FD-Score:-4.18|P-value:1.01E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.83|P-value:4.84E-5 ID:SGTC_791|Compound:1348-1292|FD-Score:3.35|P-value:3.12E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.65|P-value:1.01E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.49|P-value:2.26E-6 ID:SGTC_1199|Compound:1638-0010|FD-Score:-3.67|P-value:9.11E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.68|P-value:8.53E-5 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.08|P-value:8.24E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.13|P-value:7.08E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.29|P-value:5.93E-6 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.41|P-value:2.53E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.41|P-value:3.41E-6 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.74|P-value:6.66E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.69|P-value:8.18E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.29|P-value:6.10E-6 ID:SGTC_1637|Compound:st007924|FD-Score:4.77|P-value:5.73E-7 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.25|P-value:4.57E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.91|P-value:3.32E-5 ID:SGTC_1923|Compound:st058458|FD-Score:3.33|P-value:3.37E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.29|P-value:3.93E-4 ID:SGTC_2030|Compound:5175110|FD-Score:-3.59|P-value:1.28E-4 ID:SGTC_2043|Compound:5101342|FD-Score:-3.32|P-value:3.53E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.36|P-value:2.99E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.31|P-value:3.68E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.89|P-value:3.07E-7 ID:SGTC_2421|Compound:5690543|FD-Score:3.68|P-value:8.53E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-4.05|P-value:1.80E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.12|P-value:7.19E-4 ID:SGTC_2700|Compound:st077718|FD-Score:3.79|P-value:5.61E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.04|P-value:9.58E-4 ID:SGTC_2892|Compound:9047358|FD-Score:-3.38|P-value:2.83E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.18|P-value:5.79E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.79|P-value:5.59E-5 ID:SGTC_2991|Compound:9074669|FD-Score:3.08|P-value:8.21E-4 ID:SGTC_3106|Compound:9121286|FD-Score:3.25|P-value:4.57E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.24|P-value:4.74E-4 ID:SGTC_3238|Compound:9133470|FD-Score:4.52|P-value:1.99E-6

Top fitness defect scores for YHR135C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2420 aureobasidin a 4.89 50.0 nM 3.07E-7 19 5.10E-7
2 SGTC_1637 st007924 4.77 17.4 µM 5.73E-7 13 9.30E-7
3 SGTC_3238 9133470 4.52 49.5 µM 1.99E-6 4 3.09E-6
4 SGTC_1129 3453-1384 4.49 223.0 µM 2.26E-6 26 3.49E-6
5 SGTC_1350 1495-0454 4.41 146.0 µM 3.41E-6 15 5.17E-6
6 SGTC_1281 0884-0031 4.29 11.8 µM 5.93E-6 fatty acid desaturase (OLE1) 18 8.82E-6
7 SGTC_1636 st007707 4.29 68.9 µM 6.10E-6 42 9.06E-6
8 SGTC_2937 9044753 3.79 11.3 µM 5.59E-5 60S ribosome export 39 7.65E-5
9 SGTC_2700 st077718 3.79 96.8 µM 5.61E-5 16 7.68E-5
10 SGTC_1470 k295-0292 3.74 231.0 µM 6.66E-5 18 9.05E-5
11 SGTC_1511 0906-3109 3.69 28.5 µM 8.18E-5 excess fatty acid 61 1.10E-4
12 SGTC_2421 5690543 3.68 90.7 µM 8.53E-5 23 1.15E-4
13 SGTC_1207 2099-0101 3.68 141.0 µM 8.53E-5 28 1.15E-4
14 SGTC_1341 1486-1360 3.41 280.0 µM 2.53E-4 47 3.28E-4
15 SGTC_687 k029-0044 3.40 34.9 µM 2.58E-4 PDR1 33 3.33E-4
16 SGTC_2061 5245884 3.36 81.0 µM 2.99E-4 tubulin folding & SWR complex 42 3.85E-4
17 SGTC_791 1348-1292 3.35 225.0 µM 3.12E-4 65 4.01E-4
18 SGTC_1923 st058458 3.33 19.1 µM 3.37E-4 61 4.32E-4
19 SGTC_2069 5228469 3.31 200.0 µM 3.68E-4 36 4.69E-4
20 SGTC_2029 5175081 3.29 200.0 µM 3.93E-4 44 5.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.84E-16 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.100 6.17E-9 YLL055W YCT1 hom High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
0.088 3.38E-7 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.081 2.63E-6 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.081 2.69E-6 YKL105C SEG2 hom Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes
0.079 5.25E-6 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.078 5.83E-6 YGR256W GND2 hom 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication
0.078 6.09E-6 YGR074W SMD1 het Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; protein abundance increases in response to DNA replication stress
0.077 7.88E-6 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.077 8.04E-6 YNR071C_p YNR071C_p hom Putative aldose 1-epimerase
0.077 8.47E-6 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.075 1.32E-5 YML017W PSP2 hom Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
0.075 1.35E-5 YKL197C PEX1 hom AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis
0.074 2.00E-5 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.073 2.07E-5 YEL039C CYC7 hom Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication