YHR137W / ARO9

Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR137W / ARO9

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.18|P-value:4.02E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.16|P-value:6.26E-6 ID:SGTC_216|Compound:k038-0035|FD-Score:3.34|P-value:2.21E-4 ID:SGTC_458|Compound:nppb|FD-Score:-3.32|P-value:2.32E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:3.25|P-value:3.18E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.70|P-value:5.15E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:4.17|P-value:5.76E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:4.00|P-value:1.33E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:2.96|P-value:9.56E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:2.97|P-value:9.18E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:4.41|P-value:1.79E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.87|P-value:2.42E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.86|P-value:1.60E-7 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.56|P-value:9.05E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.44|P-value:1.53E-6 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.35|P-value:2.13E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.94|P-value:1.74E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.14|P-value:4.85E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.93|P-value:1.81E-5 ID:SGTC_1665|Compound:st014639|FD-Score:3.82|P-value:3.04E-5 ID:SGTC_1809|Compound:st050081|FD-Score:3.61|P-value:7.40E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.32|P-value:2.31E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.27|P-value:2.84E-4 ID:SGTC_1992|Compound:st073643|FD-Score:4.39|P-value:1.98E-6 ID:SGTC_2041|Compound:5107442|FD-Score:3.04|P-value:7.11E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.24|P-value:3.27E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.57|P-value:8.30E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.61|P-value:7.45E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.32|P-value:2.48E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.41|P-value:1.73E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:4.35|P-value:2.41E-6 ID:SGTC_2620|Compound:irigenin|FD-Score:4.92|P-value:1.18E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.43|P-value:1.55E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.19|P-value:4.04E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.62|P-value:7.11E-5 ID:SGTC_2906|Compound:7926292|FD-Score:4.31|P-value:2.98E-6 ID:SGTC_3049|Compound:9092223|FD-Score:3.70|P-value:5.13E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-2.95|P-value:9.34E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.18|P-value:4.02E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:4.16|P-value:6.26E-6 ID:SGTC_216|Compound:k038-0035|FD-Score:3.34|P-value:2.21E-4 ID:SGTC_458|Compound:nppb|FD-Score:-3.32|P-value:2.32E-4 ID:SGTC_460|Compound:trequinsin|FD-Score:3.25|P-value:3.18E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.70|P-value:5.15E-5 ID:SGTC_631|Compound:k072-0230|FD-Score:4.17|P-value:5.76E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:4.00|P-value:1.33E-5 ID:SGTC_857|Compound:0438-0306|FD-Score:2.96|P-value:9.56E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:2.97|P-value:9.18E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:4.41|P-value:1.79E-6 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.87|P-value:2.42E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.86|P-value:1.60E-7 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.56|P-value:9.05E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.44|P-value:1.53E-6 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.35|P-value:2.13E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:3.94|P-value:1.74E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.14|P-value:4.85E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.93|P-value:1.81E-5 ID:SGTC_1665|Compound:st014639|FD-Score:3.82|P-value:3.04E-5 ID:SGTC_1809|Compound:st050081|FD-Score:3.61|P-value:7.40E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.32|P-value:2.31E-4 ID:SGTC_1991|Compound:st073000|FD-Score:-3.27|P-value:2.84E-4 ID:SGTC_1992|Compound:st073643|FD-Score:4.39|P-value:1.98E-6 ID:SGTC_2041|Compound:5107442|FD-Score:3.04|P-value:7.11E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.24|P-value:3.27E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.57|P-value:8.30E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.61|P-value:7.45E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.32|P-value:2.48E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.41|P-value:1.73E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:4.35|P-value:2.41E-6 ID:SGTC_2620|Compound:irigenin|FD-Score:4.92|P-value:1.18E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.43|P-value:1.55E-4 ID:SGTC_2671|Compound:danthron|FD-Score:3.19|P-value:4.04E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.62|P-value:7.11E-5 ID:SGTC_2906|Compound:7926292|FD-Score:4.31|P-value:2.98E-6 ID:SGTC_3049|Compound:9092223|FD-Score:3.70|P-value:5.13E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-2.95|P-value:9.34E-4

Top fitness defect scores for YHR137W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2620 irigenin 4.92 100.0 µM 1.18E-7 13 4.41E-7
2 SGTC_1041 0206-0046 4.86 107.0 µM 1.60E-7 19 5.81E-7
3 SGTC_1215 3852-0577 4.44 11.2 µM 1.53E-6 10 4.49E-6
4 SGTC_891 0929-0073 4.41 133.0 µM 1.79E-6 15 5.19E-6
5 SGTC_1992 st073643 4.39 23.3 µM 1.98E-6 mitochondrial processes 8 5.69E-6
6 SGTC_2515 chrysin 4.35 20.8 µM 2.41E-6 RPP1 & pyrimidine depletion 5 6.80E-6
7 SGTC_2906 7926292 4.31 26.4 µM 2.98E-6 17 8.25E-6
8 SGTC_631 k072-0230 4.17 41.5 µM 5.76E-6 60S ribosome export 14 1.50E-5
9 SGTC_61 0978-8327 4.16 98.6 µM 6.26E-6 ergosterol biosynthesis 29 1.62E-5
10 SGTC_692 k241-0027 4.00 77.8 µM 1.33E-5 7 3.20E-5
11 SGTC_1399 3562-5772 3.94 25.0 µM 1.74E-5 RPP1 & pyrimidine depletion 19 4.10E-5
12 SGTC_1492 4158-0558 3.93 28.5 µM 1.81E-5 60S ribosome export 15 4.23E-5
13 SGTC_1003 4049-0218 3.87 100.0 µM 2.42E-5 18 5.51E-5
14 SGTC_1665 st014639 3.82 11.4 µM 3.04E-5 NEO1 25 6.78E-5
15 SGTC_3049 9092223 3.70 49.5 µM 5.13E-5 31 1.09E-4
16 SGTC_579 4491-1009 3.70 110.0 µM 5.15E-5 60S ribosome export 29 1.10E-4
17 SGTC_2766 oltipraz 3.62 83.9 µM 7.11E-5 heme requiring 39 1.47E-4
18 SGTC_1809 st050081 3.61 57.6 µM 7.40E-5 21 1.52E-4
19 SGTC_2167 5876490 3.61 200.0 µM 7.45E-5 44 1.53E-4
20 SGTC_1182 1222-0449 3.56 220.0 µM 9.05E-5 27 1.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.092 1.08E-7 YHR181W SVP26 hom Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
0.086 5.61E-7 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.085 8.04E-7 YJL010C NOP9 het Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain
0.084 1.12E-6 YIR031C DAL7 hom Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.071 3.91E-5 YCL027W FUS1 hom Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate
0.071 4.17E-5 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.070 4.74E-5 YKL063C_p YKL063C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.070 4.98E-5 YBL106C SRO77 hom Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication
0.069 7.13E-5 YIL045W PIG2 hom Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
0.068 7.46E-5 YGL085W_p LCL3_p hom Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS
0.067 9.87E-5 YOR338W_p YOR338W_p hom Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication
0.066 1.18E-4 YOR286W RDL2 hom Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss
0.066 1.47E-4 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.064 1.88E-4 YKR087C OMA1 hom Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes
0.064 1.94E-4 YNR065C_p YNR065C_p hom Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene