YHR149C / SKG6

Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR149C / SKG6

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.88|P-value:5.10E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:3.14|P-value:8.25E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.23|P-value:5.71E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.05|P-value:2.45E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.21|P-value:6.45E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.31|P-value:4.60E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.69|P-value:1.09E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:4.94|P-value:3.62E-7 ID:SGTC_143|Compound:4032-1194|FD-Score:6.58|P-value:2.04E-11 ID:SGTC_144|Compound:4161-2749|FD-Score:3.39|P-value:3.49E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:8.14|P-value:1.56E-16 ID:SGTC_184|Compound:1494-0393|FD-Score:5.19|P-value:9.73E-8 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.25|P-value:1.00E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.21|P-value:6.15E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.97|P-value:3.14E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.21|P-value:6.65E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:4.16|P-value:1.53E-5 ID:SGTC_918|Compound:glabranin|FD-Score:4.75|P-value:9.53E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:3.31|P-value:4.58E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.09|P-value:9.22E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.64|P-value:1.35E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.36|P-value:3.79E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.50|P-value:2.13E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.79|P-value:7.35E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.09|P-value:9.78E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.38|P-value:3.59E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-3.22|P-value:5.87E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.27|P-value:4.86E-4 ID:SGTC_1675|Compound:st018485|FD-Score:7.00|P-value:1.07E-12 ID:SGTC_1739|Compound:st037196|FD-Score:3.87|P-value:5.27E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.09|P-value:9.99E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.39|P-value:3.44E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.13|P-value:4.04E-10 ID:SGTC_2238|Compound:6671620|FD-Score:3.27|P-value:5.37E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.03|P-value:2.25E-7 ID:SGTC_2398|Compound:5228213|FD-Score:4.10|P-value:1.97E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.72|P-value:9.52E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-4.11|P-value:1.72E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.87|P-value:4.78E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.72|P-value:9.81E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.09|P-value:9.26E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:5.07|P-value:1.85E-7 ID:SGTC_3201|Compound:9113999|FD-Score:-3.46|P-value:2.41E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.88|P-value:5.10E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:3.14|P-value:8.25E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.23|P-value:5.71E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.05|P-value:2.45E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.21|P-value:6.45E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.31|P-value:4.60E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.69|P-value:1.09E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:4.94|P-value:3.62E-7 ID:SGTC_143|Compound:4032-1194|FD-Score:6.58|P-value:2.04E-11 ID:SGTC_144|Compound:4161-2749|FD-Score:3.39|P-value:3.49E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:8.14|P-value:1.56E-16 ID:SGTC_184|Compound:1494-0393|FD-Score:5.19|P-value:9.73E-8 ID:SGTC_256|Compound:clotrimazole|FD-Score:4.25|P-value:1.00E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.21|P-value:6.15E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.97|P-value:3.14E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.21|P-value:6.65E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:4.16|P-value:1.53E-5 ID:SGTC_918|Compound:glabranin|FD-Score:4.75|P-value:9.53E-7 ID:SGTC_951|Compound:1171-0579|FD-Score:3.31|P-value:4.58E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.09|P-value:9.22E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.64|P-value:1.35E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.36|P-value:3.79E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.50|P-value:2.13E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.79|P-value:7.35E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.09|P-value:9.78E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.38|P-value:3.59E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-3.22|P-value:5.87E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.27|P-value:4.86E-4 ID:SGTC_1675|Compound:st018485|FD-Score:7.00|P-value:1.07E-12 ID:SGTC_1739|Compound:st037196|FD-Score:3.87|P-value:5.27E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.09|P-value:9.99E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.39|P-value:3.44E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.13|P-value:4.04E-10 ID:SGTC_2238|Compound:6671620|FD-Score:3.27|P-value:5.37E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.03|P-value:2.25E-7 ID:SGTC_2398|Compound:5228213|FD-Score:4.10|P-value:1.97E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.72|P-value:9.52E-5 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-4.11|P-value:1.72E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.87|P-value:4.78E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.72|P-value:9.81E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:-3.09|P-value:9.26E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:5.07|P-value:1.85E-7 ID:SGTC_3201|Compound:9113999|FD-Score:-3.46|P-value:2.41E-4

Top fitness defect scores for YHR149C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_145 3737-0113 8.14 38.4 µM 1.56E-16 DNA intercalators 8 1.97E-16
2 SGTC_1675 st018485 7.00 24.5 µM 1.07E-12 60S ribosome export 2 1.26E-12
3 SGTC_143 4032-1194 6.58 15.7 µM 2.04E-11 15 2.35E-11
4 SGTC_1926 methyl fluorone black 6.13 53.6 µM 4.04E-10 DNA intercalators 18 4.53E-10
5 SGTC_184 1494-0393 5.19 24.7 µM 9.73E-8 25 1.05E-7
6 SGTC_2771 fluoxetine 5.07 41.0 µM 1.85E-7 6 1.99E-7
7 SGTC_2289 7946404 5.03 165.1 µM 2.25E-7 55 2.41E-7
8 SGTC_131 0141-0277 4.94 33.9 µM 3.62E-7 16 3.87E-7
9 SGTC_918 glabranin 4.75 770.7 nM 9.53E-7 14 1.01E-6
10 SGTC_256 clotrimazole 4.25 625.0 nM 1.00E-5 ergosterol depletion effects on membrane 22 1.05E-5
11 SGTC_867 0518-0118 4.16 155.0 µM 1.53E-5 DNA intercalators 16 1.59E-5
12 SGTC_2398 5228213 4.10 48.8 µM 1.97E-5 iron homeostasis 34 2.04E-5
13 SGTC_66 0109-0187 4.05 42.4 µM 2.45E-5 39 2.54E-5
14 SGTC_4 0960-0234 3.88 25.7 µM 5.10E-5 Golgi 15 5.26E-5
15 SGTC_1739 st037196 3.87 92.5 µM 5.27E-5 27 5.44E-5
16 SGTC_1242 0402-0103 3.79 60.1 µM 7.35E-5 27 7.56E-5
17 SGTC_2476 5806916 3.72 10.5 µM 9.52E-5 21 9.79E-5
18 SGTC_2640 pentamidine 3.72 10.4 µM 9.81E-5 mitochondrial processes 41 1.01E-4
19 SGTC_128 0906-2981 3.69 13.4 µM 1.09E-4 20 1.12E-4
20 SGTC_1026 k007-1105 3.64 30.6 µM 1.35E-4 ERAD & cell cycle 110 1.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.295 4.04E-68 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.243 2.75E-46 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.237 6.46E-44 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.224 2.87E-39 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.219 1.08E-37 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.217 6.53E-37 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.216 9.11E-37 YBR182C-A_p YBR182C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.215 2.18E-36 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.215 2.42E-36 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.214 3.17E-36 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.214 4.64E-36 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.208 4.57E-34 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.208 5.26E-34 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.203 1.59E-32 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.202 3.76E-32 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene