Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHR159W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.159 | 1.69E-20 | YGL023C | PIB2 | hom | Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27 |
0.157 | 5.87E-20 | YMR168C | CEP3 | het | Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain |
0.153 | 4.48E-19 | YHL039W | EFM1 | hom | Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
0.150 | 2.39E-18 | YMR166C_p | YMR166C_p | hom | Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene |
0.121 | 1.94E-12 | YPL157W | TGS1 | hom | Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs |
0.120 | 3.15E-12 | YMR289W | ABZ2 | hom | Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis |
0.115 | 2.30E-11 | YGL041C_d | YGL041C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.109 | 2.49E-10 | YGR065C | VHT1 | het | High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin |
0.102 | 3.68E-9 | YDR124W_p | YDR124W_p | hom | Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor |
0.099 | 9.48E-9 | YOR133W | EFT1 | hom | Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication |
0.098 | 1.24E-8 | YBR196C-B_p | YBR196C-B_p | hom | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
0.097 | 1.55E-8 | YGL118C_d | YGL118C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.097 | 1.97E-8 | YBR170C | NPL4 | hom | Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) |
0.094 | 5.57E-8 | YDL223C | HBT1 | hom | Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis |
0.092 | 8.57E-8 | YFR032C-A | RPL29 | hom | Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog |