YHR159W_p / TDA11

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR159W / TDA11

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.71|P-value:3.28E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-6.08|P-value:9.88E-9 ID:SGTC_264|Compound:promethazine|FD-Score:3.58|P-value:5.00E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.94|P-value:1.49E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.97|P-value:1.31E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.87|P-value:3.84E-6 ID:SGTC_532|Compound:1548-0774|FD-Score:3.67|P-value:3.76E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-5.10|P-value:1.27E-6 ID:SGTC_706|Compound:4262-0057|FD-Score:4.31|P-value:3.79E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:5.29|P-value:5.82E-7 ID:SGTC_722|Compound:3534-0461|FD-Score:4.11|P-value:8.00E-5 ID:SGTC_732|Compound:3970-1727|FD-Score:4.32|P-value:3.65E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.39|P-value:9.21E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:4.56|P-value:1.38E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:3.38|P-value:9.63E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:4.13|P-value:7.41E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.52|P-value:5.62E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:4.85|P-value:4.22E-6 ID:SGTC_944|Compound:3370-0224|FD-Score:5.13|P-value:1.19E-6 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:-3.51|P-value:5.89E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:-3.89|P-value:1.64E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.81|P-value:2.32E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.44|P-value:7.45E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-4.89|P-value:3.14E-6 ID:SGTC_1860|Compound:st056228|FD-Score:4.64|P-value:9.92E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-3.89|P-value:1.64E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-4.81|P-value:4.51E-6 ID:SGTC_2278|Compound:7948257|FD-Score:3.55|P-value:5.54E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.58|P-value:5.02E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.38|P-value:2.90E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.72|P-value:3.20E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.87|P-value:1.90E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.39|P-value:8.53E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.42|P-value:8.32E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-6.38|P-value:1.93E-9 ID:SGTC_49|Compound:0717-0965|FD-Score:3.71|P-value:3.28E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-6.08|P-value:9.88E-9 ID:SGTC_264|Compound:promethazine|FD-Score:3.58|P-value:5.00E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.94|P-value:1.49E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.97|P-value:1.31E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.87|P-value:3.84E-6 ID:SGTC_532|Compound:1548-0774|FD-Score:3.67|P-value:3.76E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-5.10|P-value:1.27E-6 ID:SGTC_706|Compound:4262-0057|FD-Score:4.31|P-value:3.79E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:5.29|P-value:5.82E-7 ID:SGTC_722|Compound:3534-0461|FD-Score:4.11|P-value:8.00E-5 ID:SGTC_732|Compound:3970-1727|FD-Score:4.32|P-value:3.65E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.39|P-value:9.21E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:4.56|P-value:1.38E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:3.38|P-value:9.63E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:4.13|P-value:7.41E-5 ID:SGTC_940|Compound:3232-1287|FD-Score:-3.52|P-value:5.62E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:4.85|P-value:4.22E-6 ID:SGTC_944|Compound:3370-0224|FD-Score:5.13|P-value:1.19E-6 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:-3.51|P-value:5.89E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:-3.89|P-value:1.64E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.81|P-value:2.32E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.44|P-value:7.45E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-4.89|P-value:3.14E-6 ID:SGTC_1860|Compound:st056228|FD-Score:4.64|P-value:9.92E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-3.89|P-value:1.64E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-4.81|P-value:4.51E-6 ID:SGTC_2278|Compound:7948257|FD-Score:3.55|P-value:5.54E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.58|P-value:5.02E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.38|P-value:2.90E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.72|P-value:3.20E-4 ID:SGTC_3095|Compound:9117207|FD-Score:3.87|P-value:1.90E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.39|P-value:8.53E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.42|P-value:8.32E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-6.38|P-value:1.93E-9

Top fitness defect scores for YHR159W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_718 1130-0073 5.29 349.0 µM 5.82E-7 6 6.18E-8
2 SGTC_944 3370-0224 5.13 231.0 µM 1.19E-6 8 1.43E-7
3 SGTC_518 1021-0119 4.87 62.6 µM 3.84E-6 ERG2 16 5.65E-7
4 SGTC_941 3237-0776 4.85 460.0 µM 4.22E-6 4 6.32E-7
5 SGTC_1860 st056228 4.64 74.6 µM 9.92E-6 6 1.72E-6
6 SGTC_780 0109-0199 4.56 192.0 µM 1.38E-5 6 2.54E-6
7 SGTC_2592 piperlongumine 4.38 83.3 µM 2.90E-5 TSC3-RPN4 25 6.04E-6
8 SGTC_732 3970-1727 4.32 52.7 µM 3.65E-5 6 7.93E-6
9 SGTC_706 4262-0057 4.31 46.9 µM 3.79E-5 fatty acid desaturase (OLE1) 24 8.28E-6
10 SGTC_811 0416-0114 4.13 265.0 µM 7.41E-5 15 1.82E-5
11 SGTC_722 3534-0461 4.11 190.0 µM 8.00E-5 PDR1 32 1.99E-5
12 SGTC_512 prima-1 3.97 270.0 µM 1.31E-4 DNA intercalators 25 3.56E-5
13 SGTC_471 1-acyl-paf 3.94 4.0 µM 1.49E-4 DNA intercalators 31 4.13E-5
14 SGTC_3095 9117207 3.87 49.5 µM 1.90E-4 6 5.47E-5
15 SGTC_1368 1852-0141 3.81 284.0 µM 2.32E-4 ERG2 40 6.93E-5
16 SGTC_2758 dehydroepiandrosterone 3.72 69.3 µM 3.20E-4 43 1.01E-4
17 SGTC_49 0717-0965 3.71 32.1 µM 3.28E-4 60S ribosome export 26 1.04E-4
18 SGTC_532 1548-0774 3.67 215.0 µM 3.76E-4 29 1.22E-4
19 SGTC_264 promethazine 3.58 12.5 mM 5.00E-4 DNA intercalators 67 1.70E-4
20 SGTC_2316 5844804 3.58 197.4 µM 5.02E-4 48 1.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 1.69E-20 YGL023C PIB2 hom Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27
0.157 5.87E-20 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.153 4.48E-19 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.150 2.39E-18 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.121 1.94E-12 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.120 3.15E-12 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.115 2.30E-11 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.109 2.49E-10 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.102 3.68E-9 YDR124W_p YDR124W_p hom Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
0.099 9.48E-9 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.098 1.24E-8 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.097 1.55E-8 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.097 1.97E-8 YBR170C NPL4 hom Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
0.094 5.57E-8 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.092 8.57E-8 YFR032C-A RPL29 hom Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog