YHR193C / EGD2

Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR193C / EGD2

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:4.03|P-value:2.18E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.17|P-value:5.68E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.99|P-value:2.52E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.32|P-value:3.77E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-4.44|P-value:2.69E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:4.65|P-value:1.16E-6 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.58|P-value:1.18E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:10.40|P-value:1.18E-26 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.14|P-value:7.17E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.28|P-value:3.79E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.47|P-value:2.13E-4 ID:SGTC_398|Compound:bronopol|FD-Score:6.90|P-value:1.09E-12 ID:SGTC_403|Compound:arphamenine a|FD-Score:5.39|P-value:2.14E-8 ID:SGTC_574|Compound:1315-0397|FD-Score:4.09|P-value:1.66E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:3.89|P-value:3.95E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.27|P-value:3.93E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.05|P-value:9.94E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.80|P-value:5.78E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.36|P-value:3.28E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.14|P-value:7.38E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:6.68|P-value:5.22E-12 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.27|P-value:4.60E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.07|P-value:9.33E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.62|P-value:1.17E-4 ID:SGTC_1861|Compound:st057647|FD-Score:6.05|P-value:3.88E-10 ID:SGTC_1932|Compound:st074806|FD-Score:4.70|P-value:8.76E-7 ID:SGTC_2057|Compound:5236571|FD-Score:3.94|P-value:3.18E-5 ID:SGTC_2166|Compound:5933061|FD-Score:4.18|P-value:1.08E-5 ID:SGTC_2391|Compound:6285546|FD-Score:4.04|P-value:2.06E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:9.15|P-value:5.73E-21 ID:SGTC_2412|Compound:st077135|FD-Score:-4.90|P-value:2.60E-7 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.72|P-value:7.89E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.45|P-value:2.00E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-4.08|P-value:1.42E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.68|P-value:9.36E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.58|P-value:1.40E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.29|P-value:3.65E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.60|P-value:1.29E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.27|P-value:4.63E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.74|P-value:7.45E-7 ID:SGTC_2857|Compound:9024691|FD-Score:4.89|P-value:3.30E-7 ID:SGTC_2881|Compound:9058953|FD-Score:3.12|P-value:7.71E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-3.40|P-value:2.41E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:4.03|P-value:2.18E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.17|P-value:5.68E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.99|P-value:2.52E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:3.32|P-value:3.77E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-4.44|P-value:2.69E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:4.65|P-value:1.16E-6 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.58|P-value:1.18E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:10.40|P-value:1.18E-26 ID:SGTC_247|Compound:mechlorethamine|FD-Score:3.14|P-value:7.17E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.28|P-value:3.79E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.47|P-value:2.13E-4 ID:SGTC_398|Compound:bronopol|FD-Score:6.90|P-value:1.09E-12 ID:SGTC_403|Compound:arphamenine a|FD-Score:5.39|P-value:2.14E-8 ID:SGTC_574|Compound:1315-0397|FD-Score:4.09|P-value:1.66E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:3.89|P-value:3.95E-5 ID:SGTC_1023|Compound:4482-3888|FD-Score:-3.27|P-value:3.93E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.05|P-value:9.94E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.80|P-value:5.78E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.36|P-value:3.28E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.14|P-value:7.38E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:6.68|P-value:5.22E-12 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.27|P-value:4.60E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.07|P-value:9.33E-4 ID:SGTC_1856|Compound:st057054|FD-Score:3.62|P-value:1.17E-4 ID:SGTC_1861|Compound:st057647|FD-Score:6.05|P-value:3.88E-10 ID:SGTC_1932|Compound:st074806|FD-Score:4.70|P-value:8.76E-7 ID:SGTC_2057|Compound:5236571|FD-Score:3.94|P-value:3.18E-5 ID:SGTC_2166|Compound:5933061|FD-Score:4.18|P-value:1.08E-5 ID:SGTC_2391|Compound:6285546|FD-Score:4.04|P-value:2.06E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:9.15|P-value:5.73E-21 ID:SGTC_2412|Compound:st077135|FD-Score:-4.90|P-value:2.60E-7 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.72|P-value:7.89E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.45|P-value:2.00E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-4.08|P-value:1.42E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.68|P-value:9.36E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.58|P-value:1.40E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.29|P-value:3.65E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.60|P-value:1.29E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.27|P-value:4.63E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.74|P-value:7.45E-7 ID:SGTC_2857|Compound:9024691|FD-Score:4.89|P-value:3.30E-7 ID:SGTC_2881|Compound:9058953|FD-Score:3.12|P-value:7.71E-4 ID:SGTC_2894|Compound:9048625|FD-Score:-3.40|P-value:2.41E-4

Top fitness defect scores for YHR193C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_177 1327-0068 10.40 8.4 µM 1.18E-26 5 9.26E-26
2 SGTC_2405 ticlatone 9.15 3.5 µM 5.73E-21 12 2.75E-20
3 SGTC_398 bronopol 6.90 33.3 µM 1.09E-12 RNA processing & uracil transport 6 2.58E-12
4 SGTC_1424 4048-1941 6.68 275.0 µM 5.22E-12 3 1.17E-11
5 SGTC_1861 st057647 6.05 17.4 µM 3.88E-10 1 7.44E-10
6 SGTC_403 arphamenine a 5.39 50.0 µM 2.14E-8 60S ribosome export 6 3.55E-8
7 SGTC_2857 9024691 4.89 58.4 µM 3.30E-7 10 4.98E-7
8 SGTC_2723 salbutamol 4.74 83.6 µM 7.45E-7 4 1.09E-6
9 SGTC_1932 st074806 4.70 40.9 µM 8.76E-7 9 1.28E-6
10 SGTC_166 k072-0058 4.65 166.4 µM 1.16E-6 DNA intercalators 19 1.68E-6
11 SGTC_2166 5933061 4.18 31.5 µM 1.08E-5 tubulin folding & SWR complex 33 1.44E-5
12 SGTC_574 1315-0397 4.09 40.0 µM 1.66E-5 33 2.18E-5
13 SGTC_2391 6285546 4.04 200.0 µM 2.06E-5 17 2.70E-5
14 SGTC_62 0180-0423 4.03 3.2 µM 2.18E-5 60S ribosome export 15 2.84E-5
15 SGTC_122 0236-0016 3.99 402.4 µM 2.52E-5 RNA processing & uracil transport 30 3.27E-5
16 SGTC_2057 5236571 3.94 38.3 µM 3.18E-5 RPP1 & pyrimidine depletion 32 4.11E-5
17 SGTC_881 0833-0569 3.89 170.0 µM 3.95E-5 31 5.06E-5
18 SGTC_1165 k072-0275 3.80 30.3 µM 5.78E-5 47 7.31E-5
19 SGTC_2555 cholic acid 3.72 100.0 µM 7.89E-5 21 9.88E-5
20 SGTC_2614 arthonioic acid 3.68 13.4 µM 9.36E-5 28 1.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.288 6.79E-65 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.249 1.85E-48 YGR134W CAF130 hom Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
0.147 1.43E-17 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.129 6.85E-14 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
0.127 1.84E-13 YJR049C UTR1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication
0.122 1.68E-12 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.118 8.09E-12 YKL075C_p YKL075C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin
0.115 2.05E-11 YBR265W TSC10 het 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
0.115 2.30E-11 YKL090W CUE2 hom Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
0.095 3.43E-8 YHR037W PUT2 hom Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
0.092 1.04E-7 YMR042W ARG80 hom Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
0.091 1.50E-7 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.090 1.88E-7 YHL042W_p YHL042W_p hom Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.089 2.25E-7 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.088 3.55E-7 YGR147C NAT2 het Protein with an apparent role in acetylation of N-terminal methionine residues