YHR194W / MDM31

Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR194W / MDM31

Click on Significant Values for Screen Details ID:SGTC_88|Compound:0180-0332|FD-Score:3.99|P-value:6.30E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:3.99|P-value:6.28E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.49|P-value:4.12E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.56|P-value:1.87E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.32|P-value:4.51E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:-4.12|P-value:1.99E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:8.34|P-value:2.87E-16 ID:SGTC_236|Compound:1509-0011|FD-Score:4.43|P-value:9.91E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:5.13|P-value:3.67E-7 ID:SGTC_446|Compound:go6976|FD-Score:3.59|P-value:2.89E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.42|P-value:3.16E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.47|P-value:4.46E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.55|P-value:3.36E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.34|P-value:6.90E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.93|P-value:1.00E-6 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.78|P-value:2.05E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.41|P-value:1.10E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.38|P-value:6.02E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.14|P-value:3.41E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.37|P-value:6.20E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.64|P-value:2.36E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.09|P-value:4.11E-5 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.89|P-value:9.20E-5 ID:SGTC_1609|Compound:st001574|FD-Score:3.51|P-value:3.81E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.58|P-value:5.18E-6 ID:SGTC_1887|Compound:st057648|FD-Score:3.71|P-value:1.84E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.43|P-value:5.03E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.97|P-value:6.78E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.49|P-value:4.04E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-4.24|P-value:1.22E-5 ID:SGTC_2352|Compound:9027995|FD-Score:3.62|P-value:2.55E-4 ID:SGTC_2357|Compound:9067248|FD-Score:5.05|P-value:5.53E-7 ID:SGTC_2365|Compound:9042475|FD-Score:5.19|P-value:2.67E-7 ID:SGTC_2424|Compound:5537928|FD-Score:3.33|P-value:7.18E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.36|P-value:6.52E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.41|P-value:1.08E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.95|P-value:7.44E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-7.41|P-value:1.18E-13 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-10.70|P-value:4.15E-26 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.29|P-value:8.04E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.38|P-value:5.95E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.29|P-value:4.88E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.23|P-value:2.38E-5 ID:SGTC_2811|Compound:7967822|FD-Score:4.37|P-value:1.28E-5 ID:SGTC_2872|Compound:9044037|FD-Score:3.43|P-value:5.02E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.76|P-value:1.50E-4 ID:SGTC_3035|Compound:9091303|FD-Score:3.43|P-value:5.10E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.99|P-value:6.30E-5 ID:SGTC_91|Compound:0417-1751|FD-Score:3.99|P-value:6.28E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.49|P-value:4.12E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.56|P-value:1.87E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.32|P-value:4.51E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:-4.12|P-value:1.99E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:8.34|P-value:2.87E-16 ID:SGTC_236|Compound:1509-0011|FD-Score:4.43|P-value:9.91E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:5.13|P-value:3.67E-7 ID:SGTC_446|Compound:go6976|FD-Score:3.59|P-value:2.89E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.42|P-value:3.16E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.47|P-value:4.46E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.55|P-value:3.36E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.34|P-value:6.90E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:4.93|P-value:1.00E-6 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.78|P-value:2.05E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.41|P-value:1.10E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.38|P-value:6.02E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.14|P-value:3.41E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.37|P-value:6.20E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.64|P-value:2.36E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:4.09|P-value:4.11E-5 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.89|P-value:9.20E-5 ID:SGTC_1609|Compound:st001574|FD-Score:3.51|P-value:3.81E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.58|P-value:5.18E-6 ID:SGTC_1887|Compound:st057648|FD-Score:3.71|P-value:1.84E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.43|P-value:5.03E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.97|P-value:6.78E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.49|P-value:4.04E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-4.24|P-value:1.22E-5 ID:SGTC_2352|Compound:9027995|FD-Score:3.62|P-value:2.55E-4 ID:SGTC_2357|Compound:9067248|FD-Score:5.05|P-value:5.53E-7 ID:SGTC_2365|Compound:9042475|FD-Score:5.19|P-value:2.67E-7 ID:SGTC_2424|Compound:5537928|FD-Score:3.33|P-value:7.18E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.36|P-value:6.52E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.41|P-value:1.08E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.95|P-value:7.44E-5 ID:SGTC_2601|Compound:securinine|FD-Score:-7.41|P-value:1.18E-13 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-10.70|P-value:4.15E-26 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.29|P-value:8.04E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.38|P-value:5.95E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.29|P-value:4.88E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.23|P-value:2.38E-5 ID:SGTC_2811|Compound:7967822|FD-Score:4.37|P-value:1.28E-5 ID:SGTC_2872|Compound:9044037|FD-Score:3.43|P-value:5.02E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.76|P-value:1.50E-4 ID:SGTC_3035|Compound:9091303|FD-Score:3.43|P-value:5.10E-4

Top fitness defect scores for YHR194W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_141 0443-0274 8.34 32.3 µM 2.87E-16 mitochondrial response to ROS 9 3.74E-17
2 SGTC_2365 9042475 5.19 200.0 µM 2.67E-7 12 1.04E-7
3 SGTC_421 streptovitacin 5.13 30.0 mM 3.67E-7 4 1.45E-7
4 SGTC_2357 9067248 5.05 200.0 µM 5.53E-7 5 2.23E-7
5 SGTC_1075 aripiprazole 4.93 15.2 µM 1.00E-6 10 4.19E-7
6 SGTC_1103 duloxetine 4.78 36.1 µM 2.05E-6 11 8.91E-7
7 SGTC_1623 st003709 4.58 20.3 µM 5.18E-6 calcium & mitochondrial duress 47 2.37E-6
8 SGTC_236 1509-0011 4.43 5.3 µM 9.91E-6 361 4.70E-6
9 SGTC_2553 4-methylesculetin 4.41 85.1 µM 1.08E-5 12 5.17E-6
10 SGTC_1160 4092-0570 4.41 10.5 µM 1.10E-5 plasma membrane duress 29 5.28E-6
11 SGTC_2811 7967822 4.37 32.5 µM 1.28E-5 13 6.19E-6
12 SGTC_2753 fluvastatin 4.23 17.1 µM 2.38E-5 azole & statin 27 1.19E-5
13 SGTC_1339 1486-1321 4.14 22.7 µM 3.41E-5 ERG2 17 1.74E-5
14 SGTC_1414 3917-0015 4.09 5.4 µM 4.11E-5 9 2.12E-5
15 SGTC_91 0417-1751 3.99 58.4 µM 6.28E-5 Golgi 52 3.32E-5
16 SGTC_88 0180-0332 3.99 8.7 µM 6.30E-5 22 3.33E-5
17 SGTC_2033 5192550 3.97 145.0 µM 6.78E-5 14 3.60E-5
18 SGTC_2575 plumbagin 3.95 510.0 nM 7.44E-5 superoxide 42 3.97E-5
19 SGTC_1479 0549-0158 3.89 134.0 µM 9.20E-5 27 4.97E-5
20 SGTC_2873 9040596 3.76 71.4 µM 1.50E-4 53 8.34E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 2.23E-48 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.231 7.82E-42 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.216 1.42E-36 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.211 5.11E-35 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.183 1.35E-26 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.173 5.87E-24 YGL144C ROG1 hom Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.162 3.91E-21 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.156 1.03E-19 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.147 1.12E-17 YPR047W MSF1 hom Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase
0.145 2.47E-17 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.143 6.48E-17 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.142 1.20E-16 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.139 6.17E-16 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.138 9.48E-16 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.136 2.84E-15 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother