YHR209W / CRG1

S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin

Zygosity: Homozygous strain
fixedexpanded
Profile for YHR209W / CRG1

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:-4.79|P-value:8.27E-7 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.51|P-value:2.27E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.56|P-value:1.86E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.27|P-value:5.51E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:46.70|P-value:0 ID:SGTC_349|Compound:k015-0014|FD-Score:4.11|P-value:1.97E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:3.19|P-value:7.26E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.57|P-value:2.51E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:-5.32|P-value:5.09E-8 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.17|P-value:7.59E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:14.20|P-value:6.46E-46 ID:SGTC_422|Compound:cantharidin|FD-Score:14.90|P-value:2.57E-50 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.71|P-value:1.05E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.48|P-value:2.52E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.56|P-value:1.40E-8 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.29|P-value:4.93E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.72|P-value:9.97E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.74|P-value:9.08E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:3.61|P-value:1.54E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.92|P-value:4.49E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:5.17|P-value:1.22E-7 ID:SGTC_891|Compound:0929-0073|FD-Score:3.50|P-value:2.33E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.98|P-value:3.46E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:4.11|P-value:2.02E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.65|P-value:1.72E-6 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.28|P-value:5.31E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:-3.38|P-value:3.58E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.87|P-value:5.36E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:6.01|P-value:9.30E-10 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.10|P-value:9.75E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.17|P-value:7.70E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.15|P-value:8.23E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:6.62|P-value:1.88E-11 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.61|P-value:1.52E-4 ID:SGTC_1776|Compound:st049249|FD-Score:4.73|P-value:1.17E-6 ID:SGTC_1778|Compound:st046819|FD-Score:3.31|P-value:4.73E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.87|P-value:5.62E-7 ID:SGTC_1799|Compound:st045822|FD-Score:3.60|P-value:1.60E-4 ID:SGTC_1916|Compound:st067606|FD-Score:4.15|P-value:1.66E-5 ID:SGTC_1933|Compound:st074711|FD-Score:3.43|P-value:3.02E-4 ID:SGTC_2073|Compound:5212005|FD-Score:4.94|P-value:4.05E-7 ID:SGTC_2084|Compound:5306078|FD-Score:3.10|P-value:9.79E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.38|P-value:3.61E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.61|P-value:1.54E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-6.69|P-value:1.13E-11 ID:SGTC_2278|Compound:7948257|FD-Score:4.66|P-value:1.59E-6 ID:SGTC_2279|Compound:7948423|FD-Score:7.71|P-value:6.75E-15 ID:SGTC_2298|Compound:7976326|FD-Score:3.74|P-value:9.29E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.09|P-value:9.96E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.84|P-value:6.49E-7 ID:SGTC_2450|Compound:5739737|FD-Score:3.20|P-value:7.00E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:37.20|P-value:1.78E-302 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.70|P-value:1.06E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.11|P-value:9.60E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.22|P-value:1.19E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.49|P-value:2.38E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.26|P-value:5.65E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-3.19|P-value:7.15E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.29|P-value:5.04E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.88|P-value:5.33E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.24|P-value:5.95E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.34|P-value:4.20E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.29|P-value:4.92E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-4.08|P-value:2.24E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.71|P-value:1.04E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.75|P-value:8.98E-5 ID:SGTC_2977|Compound:9011197|FD-Score:4.59|P-value:2.31E-6 ID:SGTC_3234|Compound:9132280|FD-Score:3.38|P-value:3.63E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.24|P-value:5.99E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-4.79|P-value:8.27E-7 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.51|P-value:2.27E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.56|P-value:1.86E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.27|P-value:5.51E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:46.70|P-value:0 ID:SGTC_349|Compound:k015-0014|FD-Score:4.11|P-value:1.97E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:3.19|P-value:7.26E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:4.57|P-value:2.51E-6 ID:SGTC_358|Compound:0075-0058|FD-Score:-5.32|P-value:5.09E-8 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.17|P-value:7.59E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:14.20|P-value:6.46E-46 ID:SGTC_422|Compound:cantharidin|FD-Score:14.90|P-value:2.57E-50 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.71|P-value:1.05E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.48|P-value:2.52E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.56|P-value:1.40E-8 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.29|P-value:4.93E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.72|P-value:9.97E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.74|P-value:9.08E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:3.61|P-value:1.54E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.92|P-value:4.49E-5 ID:SGTC_793|Compound:0488-0545|FD-Score:5.17|P-value:1.22E-7 ID:SGTC_891|Compound:0929-0073|FD-Score:3.50|P-value:2.33E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.98|P-value:3.46E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:4.11|P-value:2.02E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.65|P-value:1.72E-6 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.28|P-value:5.31E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:-3.38|P-value:3.58E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.87|P-value:5.36E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:6.01|P-value:9.30E-10 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.10|P-value:9.75E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:3.17|P-value:7.70E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.15|P-value:8.23E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:6.62|P-value:1.88E-11 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.61|P-value:1.52E-4 ID:SGTC_1776|Compound:st049249|FD-Score:4.73|P-value:1.17E-6 ID:SGTC_1778|Compound:st046819|FD-Score:3.31|P-value:4.73E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.87|P-value:5.62E-7 ID:SGTC_1799|Compound:st045822|FD-Score:3.60|P-value:1.60E-4 ID:SGTC_1916|Compound:st067606|FD-Score:4.15|P-value:1.66E-5 ID:SGTC_1933|Compound:st074711|FD-Score:3.43|P-value:3.02E-4 ID:SGTC_2073|Compound:5212005|FD-Score:4.94|P-value:4.05E-7 ID:SGTC_2084|Compound:5306078|FD-Score:3.10|P-value:9.79E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.38|P-value:3.61E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.61|P-value:1.54E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-6.69|P-value:1.13E-11 ID:SGTC_2278|Compound:7948257|FD-Score:4.66|P-value:1.59E-6 ID:SGTC_2279|Compound:7948423|FD-Score:7.71|P-value:6.75E-15 ID:SGTC_2298|Compound:7976326|FD-Score:3.74|P-value:9.29E-5 ID:SGTC_2432|Compound:5630864|FD-Score:3.09|P-value:9.96E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.84|P-value:6.49E-7 ID:SGTC_2450|Compound:5739737|FD-Score:3.20|P-value:7.00E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:37.20|P-value:1.78E-302 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.70|P-value:1.06E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.11|P-value:9.60E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.22|P-value:1.19E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.49|P-value:2.38E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.26|P-value:5.65E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-3.19|P-value:7.15E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.29|P-value:5.04E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.88|P-value:5.33E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.24|P-value:5.95E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.34|P-value:4.20E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.29|P-value:4.92E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-4.08|P-value:2.24E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.71|P-value:1.04E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.75|P-value:8.98E-5 ID:SGTC_2977|Compound:9011197|FD-Score:4.59|P-value:2.31E-6 ID:SGTC_3234|Compound:9132280|FD-Score:3.38|P-value:3.63E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.24|P-value:5.99E-4

Top fitness defect scores for YHR209W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_241 5hr heat shock (37°C) + cantharidin 46.70 155.4 µM 0 cell wall signaling 1 0
2 SGTC_2489 cantharidin 37.20 73.4 µM 1.78E-302 cell wall signaling 1 1.05E-302
3 SGTC_422 cantharidin 14.90 155.0 µM 2.57E-50 cell wall signaling 3 2.32E-50
4 SGTC_408 cantharidin 14.20 100.0 µM 6.46E-46 cell wall signaling 3 5.86E-46
5 SGTC_2279 7948423 7.71 32.9 µM 6.75E-15 1 6.50E-15
6 SGTC_1564 D-Arginine 6.62 115.0 µM 1.88E-11 6 1.83E-11
7 SGTC_1117 retinoic acid 6.01 1.1 µM 9.30E-10 3 9.06E-10
8 SGTC_525 k781-2675 5.56 26.7 µM 1.40E-8 redox potentiating 29 1.37E-8
9 SGTC_793 0488-0545 5.17 106.0 µM 1.22E-7 6 1.19E-7
10 SGTC_2073 5212005 4.94 126.0 µM 4.05E-7 3 3.97E-7
11 SGTC_1779 st039427 4.87 55.0 µM 5.62E-7 9 5.51E-7
12 SGTC_2435 5706476 4.84 10.6 µM 6.49E-7 11 6.37E-7
13 SGTC_1776 st049249 4.73 45.9 µM 1.17E-6 6 1.15E-6
14 SGTC_2278 7948257 4.66 134.3 µM 1.59E-6 13 1.57E-6
15 SGTC_1077 5-fluorocytosine 4.65 377.0 nM 1.72E-6 exosome 9 1.69E-6
16 SGTC_2977 9011197 4.59 71.4 µM 2.31E-6 9 2.26E-6
17 SGTC_353 1988-1175 4.57 58.3 µM 2.51E-6 unfolded protein response 16 2.47E-6
18 SGTC_1916 st067606 4.15 49.2 µM 1.66E-5 30 1.64E-5
19 SGTC_349 k015-0014 4.11 24.0 µM 1.97E-5 16 1.94E-5
20 SGTC_990 3985-0011 4.11 41.3 µM 2.02E-5 amide catabolism 16 1.99E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.336 2.09E-89 YPL089C RLM1 hom MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication
0.290 3.49E-66 YPL017C IRC15 hom Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
0.284 1.85E-63 YER133W GLC7 het Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
0.260 5.39E-53 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.247 5.54E-48 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.236 7.15E-44 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.227 2.49E-40 YJR105W ADO1 hom Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
0.205 2.83E-33 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.199 3.65E-31 YJL148W RPA34 hom RNA polymerase I subunit A34.5
0.190 2.03E-28 YML035C AMD1 hom AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools
0.188 5.26E-28 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.186 1.56E-27 YML094W GIM5 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.184 4.39E-27 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.179 1.62E-25 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.177 4.27E-25 YJR018W_d YJR018W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data