S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YHR209W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.336 | 2.09E-89 | YPL089C | RLM1 | hom | MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication |
0.290 | 3.49E-66 | YPL017C | IRC15 | hom | Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci |
0.284 | 1.85E-63 | YER133W | GLC7 | het | Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest |
0.260 | 5.39E-53 | YJL095W | BCK1 | hom | Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p |
0.247 | 5.54E-48 | YLR027C | AAT2 | hom | Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells |
0.236 | 7.15E-44 | YCR063W | BUD31 | hom | Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis |
0.227 | 2.49E-40 | YJR105W | ADO1 | hom | Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle |
0.205 | 2.83E-33 | YDR429C | TIF35 | het | eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation |
0.199 | 3.65E-31 | YJL148W | RPA34 | hom | RNA polymerase I subunit A34.5 |
0.190 | 2.03E-28 | YML035C | AMD1 | hom | AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools |
0.188 | 5.26E-28 | YCR064C_d | YCR064C_d | hom | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 |
0.186 | 1.56E-27 | YML094W | GIM5 | hom | Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it |
0.184 | 4.39E-27 | YDR260C | SWM1 | hom | Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation |
0.179 | 1.62E-25 | YHR030C | SLT2 | hom | Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway |
0.177 | 4.27E-25 | YJR018W_d | YJR018W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |