HIPHOP chemogenomics database

YHR209W / CRG1

S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin

Zygosity: Homozygous strain

fixedexpanded
Profile for YHR209W / CRG1

Click on Significant Values for Screen Details

Top fitness defect scores for YHR209W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_241	5hr heat shock (37°C) + cantharidin	46.70	155.4 µM	0	cell wall signaling	1	0
2	SGTC_2489	cantharidin	37.20	73.4 µM	1.78E-302	cell wall signaling	1	1.05E-302
3	SGTC_422	cantharidin	14.90	155.0 µM	2.57E-50	cell wall signaling	3	2.32E-50
4	SGTC_408	cantharidin	14.20	100.0 µM	6.46E-46	cell wall signaling	3	5.86E-46
5	SGTC_2279	7948423	7.71	32.9 µM	6.75E-15		1	6.50E-15
6	SGTC_1564	D-Arginine	6.62	115.0 µM	1.88E-11		6	1.83E-11
7	SGTC_1117	retinoic acid	6.01	1.1 µM	9.30E-10		3	9.06E-10
8	SGTC_525	k781-2675	5.56	26.7 µM	1.40E-8	redox potentiating	29	1.37E-8
9	SGTC_793	0488-0545	5.17	106.0 µM	1.22E-7		6	1.19E-7
10	SGTC_2073	5212005	4.94	126.0 µM	4.05E-7		3	3.97E-7
11	SGTC_1779	st039427	4.87	55.0 µM	5.62E-7		9	5.51E-7
12	SGTC_2435	5706476	4.84	10.6 µM	6.49E-7		11	6.37E-7
13	SGTC_1776	st049249	4.73	45.9 µM	1.17E-6		6	1.15E-6
14	SGTC_2278	7948257	4.66	134.3 µM	1.59E-6		13	1.57E-6
15	SGTC_1077	5-fluorocytosine	4.65	377.0 nM	1.72E-6	exosome	9	1.69E-6
16	SGTC_2977	9011197	4.59	71.4 µM	2.31E-6		9	2.26E-6
17	SGTC_353	1988-1175	4.57	58.3 µM	2.51E-6	unfolded protein response	16	2.47E-6
18	SGTC_1916	st067606	4.15	49.2 µM	1.66E-5		30	1.64E-5
19	SGTC_349	k015-0014	4.11	24.0 µM	1.97E-5		16	1.94E-5
20	SGTC_990	3985-0011	4.11	41.3 µM	2.02E-5	amide catabolism	16	1.99E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.336	2.09E-89	YPL089C	RLM1	hom	MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication
0.290	3.49E-66	YPL017C	IRC15	hom	Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
0.284	1.85E-63	YER133W	GLC7	het	Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
0.260	5.39E-53	YJL095W	BCK1	hom	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.247	5.54E-48	YLR027C	AAT2	hom	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.236	7.15E-44	YCR063W	BUD31	hom	Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.227	2.49E-40	YJR105W	ADO1	hom	Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
0.205	2.83E-33	YDR429C	TIF35	het	eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.199	3.65E-31	YJL148W	RPA34	hom	RNA polymerase I subunit A34.5
0.190	2.03E-28	YML035C	AMD1	hom	AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools
0.188	5.26E-28	YCR064C_d	YCR064C_d	hom	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.186	1.56E-27	YML094W	GIM5	hom	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.184	4.39E-27	YDR260C	SWM1	hom	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.179	1.62E-25	YHR030C	SLT2	hom	Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.177	4.27E-25	YJR018W_d	YJR018W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data