HIPHOP chemogenomics database

YIL003W / CFD1

Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol

Zygosity: Heterozygous strain

fixedexpanded
Profile for YIL003W / CFD1

Click on Significant Values for Screen Details

Top fitness defect scores for YIL003W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_163	1327-0036	7.32	7.5 µM	1.82E-16		26	1.23E-13	0.04
2	SGTC_2329	6138490	5.52	200.0 µM	3.15E-10		3	1.72E-8	0.48
3	SGTC_2651	1327-0036	4.96	5.0 µM	1.20E-8		40	3.44E-7	0.29
4	SGTC_513	4245-1575	4.69	41.7 µM	6.53E-8	unfolded protein response	21	1.38E-6	0.23
5	SGTC_2064	5220758	4.18	200.0 µM	1.17E-6		4	1.47E-5	0.16
6	SGTC_1374	2889-5571	4.15	141.0 µM	1.33E-6	RSC complex & mRNA processing	38	1.63E-5	0.10
7	SGTC_214	4373-3496	3.94	70.0 µM	4.04E-6		18	4.08E-5	0.06
8	SGTC_3303	9125618	3.94	40.6 µM	4.13E-6		9	4.15E-5	0.02
9	SGTC_108	0509-0257	3.93	621.1 µM	4.27E-6		14	4.26E-5	0.10
10	SGTC_564	3555-0129	3.81	330.0 µM	7.69E-6		4	6.90E-5	0.16
11	SGTC_2582	agaric acid	3.77	100.0 µM	9.33E-6	redox potentiating	36	8.08E-5	0.16
12	SGTC_81	0411-0046	3.68	10.0 µM	1.47E-5		42	1.17E-4	0.01
13	SGTC_459	nigericin	3.51	15.3 µM	3.31E-5		13	2.28E-4	0.19
14	SGTC_309	k408-0051	3.36	1.5 µM	6.30E-5		40	3.85E-4	0.01
15	SGTC_1825	st052143	3.35	62.6 µM	6.55E-5		10	3.97E-4	0.04
16	SGTC_1271	0832-2808	3.34	169.0 µM	7.01E-5		15	4.20E-4	0.07
17	SGTC_2619	obliquin	3.34	87.9 µM	7.14E-5	cell wall	39	4.26E-4	0.01
18	SGTC_104	0074-0074	3.31	591.0 µM	7.97E-5		26	4.67E-4	0.04
19	SGTC_2024	5144227	3.21	134.0 µM	1.23E-4		12	6.67E-4	0.02
20	SGTC_979	1426-2828	3.19	121.0 µM	1.33E-4		7	7.10E-4	0.13

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.322	6.02E-82	YIR008C	PRI1	het	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.315	2.62E-78	YJR013W	GPI14	het	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.313	4.69E-77	YJL019W	MPS3	het	Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.280	1.19E-61	YIR012W	SQT1	het	Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.259	1.66E-52	YFL037W	TUB2	het	Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.240	2.35E-45	YJL005W	CYR1	het	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.232	2.30E-42	YIL019W	FAF1	het	Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.226	3.06E-40	YIL022W	TIM44	het	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.214	4.52E-36	YIL129C	TAO3	het	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.205	3.11E-33	YIL046W	MET30	het	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.203	2.01E-32	YIL031W	ULP2	het	Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
0.201	6.64E-32	YJR139C	HOM6	hom	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.198	4.79E-31	YGR193C	PDX1	hom	Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.193	2.24E-29	YER052C	HOM3	hom	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.175	1.30E-24	YDR381W	YRA1	het	RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member