Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YIL024C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.137 | 1.30E-15 | YGR173W | RBG2 | hom | Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein |
0.131 | 2.48E-14 | YLL055W | YCT1 | hom | High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene |
0.120 | 2.54E-12 | YFL038C | YPT1 | het | Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) |
0.116 | 1.50E-11 | YMR059W | SEN15 | het | Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p |
0.116 | 1.56E-11 | YPR121W | THI22 | hom | Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis |
0.110 | 1.64E-10 | YLL017W | YLL017W | hom | Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication |
0.107 | 4.29E-10 | YGR122C-A_d | YGR122C-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W |
0.099 | 9.76E-9 | YLR285W | NNT1 | hom | S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination |
0.098 | 1.18E-8 | YGR112W | SHY1 | hom | Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome |
0.092 | 8.36E-8 | YOR098C | NUP1 | het | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153 |
0.092 | 8.61E-8 | YLR237W | THI7 | hom | Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia |
0.091 | 1.33E-7 | YMR096W | SNZ1 | hom | Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins |
0.091 | 1.51E-7 | YKL020C | SPT23 | hom | ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting |
0.089 | 2.72E-7 | YGL097W | SRM1 | het | Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p |
0.088 | 3.72E-7 | YIL137C | TMA108 | hom | Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease |