YIL041W / GVP36

BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL041W / GVP36

Click on Significant Values for Screen Details ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.50|P-value:5.46E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.65|P-value:6.95E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:4.11|P-value:6.08E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:4.73|P-value:5.00E-6 ID:SGTC_334|Compound:1502-1024|FD-Score:4.50|P-value:1.33E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.34|P-value:9.25E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.92|P-value:2.12E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:7.87|P-value:8.96E-14 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.99|P-value:8.82E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.84|P-value:1.66E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.74|P-value:4.73E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:3.50|P-value:5.39E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.62|P-value:3.66E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.85|P-value:1.60E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.32|P-value:9.71E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.76|P-value:4.36E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.54|P-value:4.70E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.26|P-value:3.48E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.35|P-value:8.90E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.18|P-value:4.73E-5 ID:SGTC_1832|Compound:st054113|FD-Score:-3.43|P-value:6.27E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.67|P-value:6.23E-6 ID:SGTC_2095|Compound:5432005|FD-Score:3.48|P-value:5.81E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.62|P-value:3.33E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.46|P-value:5.58E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.50|P-value:5.49E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.84|P-value:1.70E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.50|P-value:5.46E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.65|P-value:6.95E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:4.11|P-value:6.08E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:4.73|P-value:5.00E-6 ID:SGTC_334|Compound:1502-1024|FD-Score:4.50|P-value:1.33E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.34|P-value:9.25E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.92|P-value:2.12E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:7.87|P-value:8.96E-14 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.99|P-value:8.82E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.84|P-value:1.66E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.74|P-value:4.73E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:3.50|P-value:5.39E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.62|P-value:3.66E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.85|P-value:1.60E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.32|P-value:9.71E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.76|P-value:4.36E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.54|P-value:4.70E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.26|P-value:3.48E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.35|P-value:8.90E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.18|P-value:4.73E-5 ID:SGTC_1832|Compound:st054113|FD-Score:-3.43|P-value:6.27E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.67|P-value:6.23E-6 ID:SGTC_2095|Compound:5432005|FD-Score:3.48|P-value:5.81E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.62|P-value:3.33E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.46|P-value:5.58E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.50|P-value:5.49E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.84|P-value:1.70E-4

Top fitness defect scores for YIL041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_528 3492-0019 7.87 172.0 µM 8.96E-14 calcium & mitochondrial duress 75 1.79E-15
2 SGTC_445 e6 berbamine 4.92 66.0 µM 2.12E-6 NEO1-PIK1 66 4.33E-7
3 SGTC_1353 1498-1206 4.76 8.1 µM 4.36E-6 mitochondrial response to ROS 33 9.80E-7
4 SGTC_778 3456-2434 4.74 196.0 µM 4.73E-6 mitochondrial response to ROS 53 1.07E-6
5 SGTC_315 k915-0449 4.73 187.0 µM 5.00E-6 38 1.15E-6
6 SGTC_1844 rapamycin 4.67 4.0 nM 6.23E-6 124 1.47E-6
7 SGTC_254 nsc-64875 4.65 3.8 µM 6.95E-6 ergosterol depletion effects on membrane 22 1.66E-6
8 SGTC_334 1502-1024 4.50 68.5 µM 1.33E-5 6 3.47E-6
9 SGTC_1635 st007035 4.26 42.4 µM 3.48E-5 199 1.03E-5
10 SGTC_1786 berberine 4.18 21.6 µM 4.73E-5 60S ribosome export 24 1.47E-5
11 SGTC_309 k408-0051 4.11 1.5 µM 6.08E-5 43 1.95E-5
12 SGTC_1070 indatraline 3.85 8.8 µM 1.60E-4 60S ribosome export 28 5.84E-5
13 SGTC_598 3937-0236 3.84 20.2 µM 1.66E-4 ERG2 27 6.08E-5
14 SGTC_2679 rapamycin 3.84 1.0 nM 1.70E-4 153 6.24E-5
15 SGTC_917 harmaline 3.62 728.1 nM 3.66E-4 ergosterol biosynthesis 39 1.49E-4
16 SGTC_1495 4469-0029 3.54 237.0 µM 4.70E-4 135 1.98E-4
17 SGTC_792 4534-1957 3.50 155.0 µM 5.39E-4 55 2.32E-4
18 SGTC_226 1,3-diallylurea 3.50 8.3 mM 5.46E-4 18 2.35E-4
19 SGTC_2624 nerol 3.50 100.0 µM 5.49E-4 18 2.36E-4
20 SGTC_2095 5432005 3.48 200.0 µM 5.81E-4 26 2.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.310 1.34E-75 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.279 4.63E-61 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.243 3.19E-46 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.204 9.40E-33 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.191 7.90E-29 YIL065C FIS1 hom Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation
0.187 9.29E-28 YBL051C PIN4 hom Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
0.179 1.98E-25 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.175 1.83E-24 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.173 5.21E-24 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.170 3.18E-23 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.169 5.85E-23 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.166 4.61E-22 YOR069W VPS5 hom Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes
0.166 5.27E-22 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.163 2.23E-21 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.161 6.24E-21 YOR068C VAM10 hom Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering