YIL050W / PCL7

Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL050W / PCL7

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-3.25|P-value:1.97E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.43|P-value:3.78E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.11|P-value:1.61E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.01|P-value:2.42E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:2.96|P-value:3.07E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:2.98|P-value:2.74E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.38|P-value:4.68E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.41|P-value:9.79E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.03|P-value:2.23E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.39|P-value:4.66E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:2.86|P-value:4.46E-4 ID:SGTC_917|Compound:harmaline|FD-Score:2.67|P-value:9.53E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:2.68|P-value:9.16E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:2.87|P-value:4.37E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.33|P-value:5.96E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.29|P-value:7.22E-10 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.32|P-value:1.47E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.13|P-value:2.27E-9 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.00|P-value:2.53E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.04|P-value:2.20E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.74|P-value:8.44E-6 ID:SGTC_1558|Compound:st069300|FD-Score:2.93|P-value:3.40E-4 ID:SGTC_1634|Compound:st006576|FD-Score:2.99|P-value:2.69E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.30|P-value:6.93E-5 ID:SGTC_1740|Compound:st038286|FD-Score:2.78|P-value:6.29E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.99|P-value:2.62E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.36|P-value:2.89E-7 ID:SGTC_1909|Compound:st060837|FD-Score:2.77|P-value:6.49E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.10|P-value:1.70E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.19|P-value:1.11E-4 ID:SGTC_2086|Compound:5274770|FD-Score:2.68|P-value:9.33E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.10|P-value:1.69E-4 ID:SGTC_2290|Compound:7904846|FD-Score:2.80|P-value:5.68E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-2.87|P-value:9.12E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-2.87|P-value:9.11E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.29|P-value:7.30E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.28|P-value:7.65E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.30|P-value:6.81E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:3.30|P-value:6.80E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.20|P-value:1.08E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.10|P-value:1.66E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.52|P-value:2.41E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:2.82|P-value:5.30E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.60|P-value:1.66E-5 ID:SGTC_2803|Compound:7707263|FD-Score:3.13|P-value:1.45E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.15|P-value:9.53E-7 ID:SGTC_2890|Compound:9046729|FD-Score:-2.92|P-value:7.58E-4 ID:SGTC_3102|Compound:9121669|FD-Score:4.52|P-value:1.08E-7 ID:SGTC_3104|Compound:9120930|FD-Score:3.88|P-value:4.10E-6 ID:SGTC_3107|Compound:9121808|FD-Score:3.44|P-value:3.57E-5 ID:SGTC_3110|Compound:9122132|FD-Score:6.49|P-value:7.39E-14 ID:SGTC_3111|Compound:9122088|FD-Score:-2.93|P-value:7.44E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-4.31|P-value:1.10E-6 ID:SGTC_3114|Compound:9122766|FD-Score:-5.76|P-value:1.03E-10 ID:SGTC_3119|Compound:9125183|FD-Score:-3.83|P-value:1.36E-5 ID:SGTC_3136|Compound:9095672|FD-Score:-2.88|P-value:8.94E-4 ID:SGTC_3152|Compound:9099253|FD-Score:2.86|P-value:4.50E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-2.91|P-value:7.93E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.62|P-value:1.48E-5 ID:SGTC_3288|Compound:9119690|FD-Score:-3.17|P-value:2.81E-4 ID:SGTC_3328|Compound:9140624|FD-Score:4.21|P-value:6.64E-7 ID:SGTC_3333|Compound:9141820|FD-Score:-4.53|P-value:3.21E-7 ID:SGTC_3350|Compound:9150499|FD-Score:-2.94|P-value:7.02E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.25|P-value:1.97E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:3.43|P-value:3.78E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.11|P-value:1.61E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.01|P-value:2.42E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:2.96|P-value:3.07E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:2.98|P-value:2.74E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.38|P-value:4.68E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.41|P-value:9.79E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:3.03|P-value:2.23E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.39|P-value:4.66E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:2.86|P-value:4.46E-4 ID:SGTC_917|Compound:harmaline|FD-Score:2.67|P-value:9.53E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:2.68|P-value:9.16E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:2.87|P-value:4.37E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:3.33|P-value:5.96E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.29|P-value:7.22E-10 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.32|P-value:1.47E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:5.13|P-value:2.27E-9 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.00|P-value:2.53E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.04|P-value:2.20E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.74|P-value:8.44E-6 ID:SGTC_1558|Compound:st069300|FD-Score:2.93|P-value:3.40E-4 ID:SGTC_1634|Compound:st006576|FD-Score:2.99|P-value:2.69E-4 ID:SGTC_1646|Compound:st011709|FD-Score:3.30|P-value:6.93E-5 ID:SGTC_1740|Compound:st038286|FD-Score:2.78|P-value:6.29E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.99|P-value:2.62E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.36|P-value:2.89E-7 ID:SGTC_1909|Compound:st060837|FD-Score:2.77|P-value:6.49E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.10|P-value:1.70E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.19|P-value:1.11E-4 ID:SGTC_2086|Compound:5274770|FD-Score:2.68|P-value:9.33E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.10|P-value:1.69E-4 ID:SGTC_2290|Compound:7904846|FD-Score:2.80|P-value:5.68E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-2.87|P-value:9.12E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-2.87|P-value:9.11E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.29|P-value:7.30E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.28|P-value:7.65E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.30|P-value:6.81E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:3.30|P-value:6.80E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.20|P-value:1.08E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.10|P-value:1.66E-4 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.52|P-value:2.41E-5 ID:SGTC_2762|Compound:leflunomide|FD-Score:2.82|P-value:5.30E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.60|P-value:1.66E-5 ID:SGTC_2803|Compound:7707263|FD-Score:3.13|P-value:1.45E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.15|P-value:9.53E-7 ID:SGTC_2890|Compound:9046729|FD-Score:-2.92|P-value:7.58E-4 ID:SGTC_3102|Compound:9121669|FD-Score:4.52|P-value:1.08E-7 ID:SGTC_3104|Compound:9120930|FD-Score:3.88|P-value:4.10E-6 ID:SGTC_3107|Compound:9121808|FD-Score:3.44|P-value:3.57E-5 ID:SGTC_3110|Compound:9122132|FD-Score:6.49|P-value:7.39E-14 ID:SGTC_3111|Compound:9122088|FD-Score:-2.93|P-value:7.44E-4 ID:SGTC_3112|Compound:9123419|FD-Score:-4.31|P-value:1.10E-6 ID:SGTC_3114|Compound:9122766|FD-Score:-5.76|P-value:1.03E-10 ID:SGTC_3119|Compound:9125183|FD-Score:-3.83|P-value:1.36E-5 ID:SGTC_3136|Compound:9095672|FD-Score:-2.88|P-value:8.94E-4 ID:SGTC_3152|Compound:9099253|FD-Score:2.86|P-value:4.50E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-2.91|P-value:7.93E-4 ID:SGTC_3280|Compound:9140961|FD-Score:3.62|P-value:1.48E-5 ID:SGTC_3288|Compound:9119690|FD-Score:-3.17|P-value:2.81E-4 ID:SGTC_3328|Compound:9140624|FD-Score:4.21|P-value:6.64E-7 ID:SGTC_3333|Compound:9141820|FD-Score:-4.53|P-value:3.21E-7 ID:SGTC_3350|Compound:9150499|FD-Score:-2.94|P-value:7.02E-4

Top fitness defect scores for YIL050W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3110 9122132 6.49 49.5 µM 7.39E-14 redox potentiating 4 4.38E-11
2 SGTC_1029 k015-0030 5.29 64.7 µM 7.22E-10 11 5.97E-8
3 SGTC_1057 3448-5381 5.13 134.0 µM 2.27E-9 calcium & mitochondrial duress 11 1.47E-7
4 SGTC_3102 9121669 4.52 49.5 µM 1.08E-7 4 3.05E-6
5 SGTC_1800 st050079 4.36 29.1 µM 2.89E-7 NEO1-PIK1 104 6.59E-6
6 SGTC_3328 9140624 4.21 29.0 µM 6.64E-7 12 1.26E-5
7 SGTC_2830 7992007 4.15 71.4 µM 9.53E-7 17 1.68E-5
8 SGTC_3104 9120930 3.88 49.5 µM 4.10E-6 13 5.27E-5
9 SGTC_1426 4048-4480 3.74 71.7 µM 8.44E-6 60S ribosome export 23 9.30E-5
10 SGTC_3280 9140961 3.62 49.5 µM 1.48E-5 60S ribosome export 23 1.45E-4
11 SGTC_2763 lisinopril 3.60 49.3 µM 1.66E-5 16 1.58E-4
12 SGTC_2668 2',4'-dihydroxychalcone 3.52 15.1 µM 2.41E-5 25 2.12E-4
13 SGTC_3107 9121808 3.44 49.5 µM 3.57E-5 14 2.88E-4
14 SGTC_67 0335-0847 3.43 266.0 µM 3.78E-5 ubiquinone biosynthesis & proteasome 149 3.01E-4
15 SGTC_769 0302-0231 3.39 76.0 µM 4.66E-5 76 3.55E-4
16 SGTC_421 streptovitacin 3.38 30.0 mM 4.68E-5 46 3.57E-4
17 SGTC_993 3909-8757 3.33 62.7 µM 5.96E-5 46 4.31E-4
18 SGTC_2610 ononetin 3.30 44.2 µM 6.80E-5 73 4.78E-4
19 SGTC_2566 crystal violet carbinol 3.30 226.0 nM 6.81E-5 66 4.78E-4
20 SGTC_1646 st011709 3.30 75.6 µM 6.93E-5 28 4.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.01E-10 YDR153C ENT5 hom Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
0.090 1.94E-7 YOL159C-A YOL159C-A hom Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species
0.089 2.45E-7 YBL018C POP8 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.087 5.03E-7 YDR344C_d YDR344C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 8.82E-7 YDL053C PBP4 hom Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress
0.085 9.04E-7 YLL003W SFI1 het Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C
0.082 1.99E-6 YMR047C NUP116 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)
0.078 5.69E-6 YKL116C PRR1 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
0.076 1.02E-5 YLR130C ZRT2 hom Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor
0.076 1.15E-5 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.075 1.32E-5 YML081W TDA9 hom DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
0.075 1.34E-5 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.075 1.42E-5 YLR077W FMP25 hom Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria
0.075 1.56E-5 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
0.074 1.86E-5 YBL011W SCT1 hom Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed