HIPHOP chemogenomics database

YIL093C / RSM25

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain

fixedexpanded
Profile for YIL093C / RSM25

Click on Significant Values for Screen Details

Top fitness defect scores for YIL093C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_275	trichlorophene	16.20	5.7 µM	6.02E-48	mitochondrial stress	6	1.74E-59
2	SGTC_1742	st038235	12.70	28.9 µM	2.78E-30	mitochondrial stress	4	2.37E-37
3	SGTC_236	1509-0011	12.50	5.3 µM	3.61E-29		140	5.87E-36
4	SGTC_310	1273-0058	10.80	1.1 µM	3.20E-22	mitochondrial stress	34	2.90E-27
5	SGTC_173	1273-0061	9.69	2.7 µM	2.07E-18	mitochondrial stress	41	1.68E-22
6	SGTC_116	0155-0182	6.16	31.8 µM	1.57E-8	mitochondrial response to ROS	23	3.53E-10
7	SGTC_673	1082-0474	5.73	110.0 µM	1.32E-7	RSC complex & mRNA processing	25	4.98E-9
8	SGTC_1995	st072814	5.56	61.1 µM	3.03E-7		1	1.39E-8
9	SGTC_404	fumagillin	5.51	50.0 µM	3.69E-7		2	1.77E-8
10	SGTC_118	0083-0097	4.97	135.3 µM	3.95E-6	translation	59	3.35E-7
11	SGTC_831	k061-1017	4.95	217.0 µM	4.36E-6	translation	23	3.78E-7
12	SGTC_1944	st076371	4.92	56.9 µM	4.79E-6		10	4.25E-7
13	SGTC_908	3448-7491	4.84	47.7 µM	6.69E-6	mitochondrial stress	84	6.43E-7
14	SGTC_1922	5578187	4.81	25.0 µM	7.55E-6	TRP & mitochondrial translation	12	7.46E-7
15	SGTC_1674	st016616	4.72	23.6 µM	1.08E-5		13	1.17E-6
16	SGTC_2409	alverine citrate	4.71	64.0 µM	1.14E-5		37	1.24E-6
17	SGTC_2830	7992007	4.69	71.4 µM	1.23E-5		12	1.36E-6
18	SGTC_10	0279-0212	4.64	42.6 µM	1.52E-5	TRP & mitochondrial translation	79	1.77E-6
19	SGTC_119	0121-0043	4.47	24.8 µM	2.92E-5	mitochondrial stress	79	3.97E-6
20	SGTC_19	0279-0214	4.46	38.4 µM	2.95E-5	TRP & mitochondrial translation	31	4.02E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.467	4.74E-181	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.446	2.99E-163	YMR098C	ATP25	hom	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.437	3.43E-156	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.437	2.54E-156	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.426	2.20E-148	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.417	1.13E-140	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.417	5.52E-141	YDR337W	MRPS28	hom	Mitochondrial ribosomal protein of the small subunit
0.414	2.49E-139	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.414	2.70E-139	YLR091W	GEP5	hom	Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.413	9.19E-139	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.409	7.28E-136	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.407	5.65E-134	YHR168W	MTG2	hom	Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.406	1.98E-133	YNL081C	SWS2	hom	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.404	9.11E-132	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.401	4.55E-130	YLR067C	PET309	hom	Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)