YIL097W / FYV10

Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL097W / FYV10

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.52|P-value:2.66E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.43|P-value:3.72E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.11|P-value:2.41E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.74|P-value:1.59E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:3.85|P-value:7.59E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.41|P-value:4.03E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.99|P-value:4.39E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.50|P-value:4.76E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.46|P-value:3.10E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.40|P-value:4.12E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.91|P-value:6.08E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.19|P-value:7.81E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.44|P-value:3.26E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.19|P-value:8.72E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.51|P-value:2.85E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.37|P-value:4.61E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.17|P-value:9.26E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.46|P-value:5.12E-6 ID:SGTC_706|Compound:4262-0057|FD-Score:3.99|P-value:4.39E-5 ID:SGTC_707|Compound:0865-0008|FD-Score:3.55|P-value:2.46E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.47|P-value:3.23E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:5.04|P-value:3.50E-7 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.51|P-value:2.58E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.71|P-value:1.76E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:4.41|P-value:7.06E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:-4.22|P-value:1.46E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.29|P-value:5.67E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.34|P-value:5.20E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.16|P-value:8.71E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.46|P-value:3.37E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.20|P-value:1.81E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.36|P-value:4.76E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.16|P-value:9.55E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:-3.13|P-value:9.53E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:10.30|P-value:2.55E-24 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.69|P-value:1.44E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:10.50|P-value:1.64E-25 ID:SGTC_1312|Compound:1218-2183|FD-Score:-4.34|P-value:8.71E-6 ID:SGTC_1435|Compound:4092-0789|FD-Score:-3.58|P-value:1.98E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.39|P-value:4.36E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.42|P-value:4.71E-8 ID:SGTC_1652|Compound:st011932|FD-Score:3.46|P-value:3.32E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.11|P-value:2.41E-5 ID:SGTC_1746|Compound:st038117|FD-Score:3.58|P-value:2.15E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.62|P-value:2.69E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:3.39|P-value:4.29E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.18|P-value:9.00E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.22|P-value:7.80E-4 ID:SGTC_2040|Compound:5100729|FD-Score:5.87|P-value:3.86E-9 ID:SGTC_2054|Compound:5233173|FD-Score:5.21|P-value:1.45E-7 ID:SGTC_2061|Compound:5245884|FD-Score:5.25|P-value:1.16E-7 ID:SGTC_2062|Compound:5245942|FD-Score:4.12|P-value:2.50E-5 ID:SGTC_2068|Compound:5226020|FD-Score:3.22|P-value:7.69E-4 ID:SGTC_2189|Compound:6047310|FD-Score:-3.20|P-value:7.65E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.23|P-value:7.55E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.67|P-value:2.16E-6 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-4.03|P-value:3.33E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.36|P-value:4.39E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.94|P-value:5.43E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.39|P-value:4.31E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:6.94|P-value:4.24E-12 ID:SGTC_3060|Compound:1327-0027|FD-Score:5.22|P-value:1.36E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.88|P-value:7.96E-7 ID:SGTC_3138|Compound:9097216|FD-Score:-3.32|P-value:4.97E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.39|P-value:4.35E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.58|P-value:1.93E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.61|P-value:1.91E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.31|P-value:5.67E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.15|P-value:9.99E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.52|P-value:2.66E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.43|P-value:3.72E-4 ID:SGTC_57|Compound:miconazole|FD-Score:-4.11|P-value:2.41E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.74|P-value:1.59E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:3.85|P-value:7.59E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.41|P-value:4.03E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.99|P-value:4.39E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:4.50|P-value:4.76E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.46|P-value:3.10E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.40|P-value:4.12E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.91|P-value:6.08E-5 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.19|P-value:7.81E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.44|P-value:3.26E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.19|P-value:8.72E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.51|P-value:2.85E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:3.37|P-value:4.61E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.17|P-value:9.26E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-4.46|P-value:5.12E-6 ID:SGTC_706|Compound:4262-0057|FD-Score:3.99|P-value:4.39E-5 ID:SGTC_707|Compound:0865-0008|FD-Score:3.55|P-value:2.46E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.47|P-value:3.23E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:5.04|P-value:3.50E-7 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.51|P-value:2.58E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.71|P-value:1.76E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:4.41|P-value:7.06E-6 ID:SGTC_943|Compound:3253-1379|FD-Score:-4.22|P-value:1.46E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.29|P-value:5.67E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.34|P-value:5.20E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.16|P-value:8.71E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.46|P-value:3.37E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:4.20|P-value:1.81E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.36|P-value:4.76E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.16|P-value:9.55E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:-3.13|P-value:9.53E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:10.30|P-value:2.55E-24 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.69|P-value:1.44E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:10.50|P-value:1.64E-25 ID:SGTC_1312|Compound:1218-2183|FD-Score:-4.34|P-value:8.71E-6 ID:SGTC_1435|Compound:4092-0789|FD-Score:-3.58|P-value:1.98E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.39|P-value:4.36E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.42|P-value:4.71E-8 ID:SGTC_1652|Compound:st011932|FD-Score:3.46|P-value:3.32E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.11|P-value:2.41E-5 ID:SGTC_1746|Compound:st038117|FD-Score:3.58|P-value:2.15E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.62|P-value:2.69E-6 ID:SGTC_1876|Compound:myriocin|FD-Score:3.39|P-value:4.29E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.18|P-value:9.00E-4 ID:SGTC_2029|Compound:5175081|FD-Score:3.22|P-value:7.80E-4 ID:SGTC_2040|Compound:5100729|FD-Score:5.87|P-value:3.86E-9 ID:SGTC_2054|Compound:5233173|FD-Score:5.21|P-value:1.45E-7 ID:SGTC_2061|Compound:5245884|FD-Score:5.25|P-value:1.16E-7 ID:SGTC_2062|Compound:5245942|FD-Score:4.12|P-value:2.50E-5 ID:SGTC_2068|Compound:5226020|FD-Score:3.22|P-value:7.69E-4 ID:SGTC_2189|Compound:6047310|FD-Score:-3.20|P-value:7.65E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.23|P-value:7.55E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.67|P-value:2.16E-6 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-4.03|P-value:3.33E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.36|P-value:4.39E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:3.94|P-value:5.43E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.39|P-value:4.31E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:6.94|P-value:4.24E-12 ID:SGTC_3060|Compound:1327-0027|FD-Score:5.22|P-value:1.36E-7 ID:SGTC_3063|Compound:1327-0034|FD-Score:4.88|P-value:7.96E-7 ID:SGTC_3138|Compound:9097216|FD-Score:-3.32|P-value:4.97E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.39|P-value:4.35E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.58|P-value:1.93E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.61|P-value:1.91E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.31|P-value:5.67E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.15|P-value:9.99E-4

Top fitness defect scores for YIL097W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1309 pyrazolanthrone 10.50 13.4 µM 1.64E-25 2 3.26E-26
2 SGTC_1294 1000-1494 10.30 117.0 µM 2.55E-24 12 5.50E-25
3 SGTC_3059 1327-0034 6.94 3.0 µM 4.24E-12 24 2.02E-12
4 SGTC_2040 5100729 5.87 123.0 µM 3.86E-9 13 2.24E-9
5 SGTC_1635 st007035 5.42 42.4 µM 4.71E-8 151 2.94E-8
6 SGTC_2061 5245884 5.25 81.0 µM 1.16E-7 tubulin folding & SWR complex 8 7.44E-8
7 SGTC_3060 1327-0027 5.22 12.5 µM 1.36E-7 22 8.74E-8
8 SGTC_2054 5233173 5.21 129.0 µM 1.45E-7 mitochondrial response to ROS 21 9.30E-8
9 SGTC_759 3486-0358 5.04 89.3 µM 3.50E-7 10 2.31E-7
10 SGTC_3063 1327-0034 4.88 4.0 µM 7.96E-7 30 5.38E-7
11 SGTC_58 0957-0393 4.74 9.0 µM 1.59E-6 cell wall 315 1.09E-6
12 SGTC_794 k038-0031 4.71 316.0 µM 1.76E-6 ubiquinone biosynthesis & proteasome 85 1.22E-6
13 SGTC_2365 9042475 4.67 200.0 µM 2.16E-6 19 1.50E-6
14 SGTC_1750 st081859 4.62 2.4 µM 2.69E-6 endomembrane recycling 148 1.88E-6
15 SGTC_207 4185-0010 4.50 4.5 µM 4.76E-6 endomembrane recycling 69 3.39E-6
16 SGTC_871 0574-0004 4.41 149.0 µM 7.06E-6 36 5.08E-6
17 SGTC_1164 k060-0068 4.20 93.7 µM 1.81E-5 19 1.34E-5
18 SGTC_2062 5245942 4.12 200.0 µM 2.50E-5 13 1.87E-5
19 SGTC_107 0358-0022 3.99 2.7 µM 4.39E-5 SWF1 & branched chain AA biosynthesis 26 3.33E-5
20 SGTC_706 4262-0057 3.99 46.9 µM 4.39E-5 fatty acid desaturase (OLE1) 31 3.33E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.343 3.69E-93 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.336 1.87E-89 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.305 4.43E-73 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.290 3.46E-66 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.285 8.29E-64 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.272 8.18E-58 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.272 8.65E-58 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.268 3.45E-56 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.265 4.58E-55 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.260 1.05E-52 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.259 1.87E-52 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.222 9.03E-39 YNL136W EAF7 hom Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A
0.210 8.76E-35 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.199 3.89E-31 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.188 6.03E-28 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M