YIL101C / XBP1

Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL101C / XBP1

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:3.55|P-value:2.35E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.25|P-value:6.73E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.16|P-value:9.18E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:4.69|P-value:1.91E-6 ID:SGTC_512|Compound:prima-1|FD-Score:-3.61|P-value:2.12E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:4.05|P-value:3.38E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:3.25|P-value:6.79E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.15|P-value:9.58E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.16|P-value:9.15E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.40|P-value:4.39E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.86|P-value:7.27E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.45|P-value:3.34E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.40|P-value:4.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.19|P-value:8.27E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.80|P-value:1.03E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.42|P-value:4.17E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.69|P-value:1.40E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.32|P-value:1.04E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.66|P-value:1.56E-4 ID:SGTC_1622|Compound:st003707|FD-Score:-3.32|P-value:5.78E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.77|P-value:1.15E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.35|P-value:4.86E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.31|P-value:5.60E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.69|P-value:1.98E-6 ID:SGTC_1934|Compound:st074720|FD-Score:3.44|P-value:3.55E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-4.03|P-value:4.05E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.22|P-value:7.46E-4 ID:SGTC_2012|Compound:4023501|FD-Score:6.15|P-value:7.27E-10 ID:SGTC_2146|Compound:5545642|FD-Score:3.36|P-value:4.59E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.38|P-value:4.40E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.62|P-value:1.83E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.53|P-value:2.52E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.35|P-value:1.17E-16 ID:SGTC_2585|Compound:alliin|FD-Score:-3.28|P-value:6.80E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.90|P-value:8.03E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:9.12|P-value:1.55E-19 ID:SGTC_2692|Compound:st077426|FD-Score:3.22|P-value:7.48E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.79|P-value:9.49E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.73|P-value:1.22E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.32|P-value:5.81E-4 ID:SGTC_2835|Compound:9006588|FD-Score:5.24|P-value:1.25E-7 ID:SGTC_2989|Compound:9073649|FD-Score:4.78|P-value:1.27E-6 ID:SGTC_3026|Compound:9090633|FD-Score:3.25|P-value:6.85E-4 ID:SGTC_3038|Compound:9091290|FD-Score:-3.32|P-value:5.89E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.35|P-value:5.27E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.68|P-value:1.63E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.21|P-value:7.73E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-3.38|P-value:4.72E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.55|P-value:2.35E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:3.25|P-value:6.73E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.16|P-value:9.18E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:4.69|P-value:1.91E-6 ID:SGTC_512|Compound:prima-1|FD-Score:-3.61|P-value:2.12E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:4.05|P-value:3.38E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:3.25|P-value:6.79E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.15|P-value:9.58E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.16|P-value:9.15E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.40|P-value:4.39E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:3.86|P-value:7.27E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.45|P-value:3.34E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.40|P-value:4.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.19|P-value:8.27E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.80|P-value:1.03E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.42|P-value:4.17E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.69|P-value:1.40E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.32|P-value:1.04E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.66|P-value:1.56E-4 ID:SGTC_1622|Compound:st003707|FD-Score:-3.32|P-value:5.78E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.77|P-value:1.15E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.35|P-value:4.86E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.31|P-value:5.60E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.69|P-value:1.98E-6 ID:SGTC_1934|Compound:st074720|FD-Score:3.44|P-value:3.55E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-4.03|P-value:4.05E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.22|P-value:7.46E-4 ID:SGTC_2012|Compound:4023501|FD-Score:6.15|P-value:7.27E-10 ID:SGTC_2146|Compound:5545642|FD-Score:3.36|P-value:4.59E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.38|P-value:4.40E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.62|P-value:1.83E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.53|P-value:2.52E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.35|P-value:1.17E-16 ID:SGTC_2585|Compound:alliin|FD-Score:-3.28|P-value:6.80E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-4.90|P-value:8.03E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:9.12|P-value:1.55E-19 ID:SGTC_2692|Compound:st077426|FD-Score:3.22|P-value:7.48E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.79|P-value:9.49E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.73|P-value:1.22E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.32|P-value:5.81E-4 ID:SGTC_2835|Compound:9006588|FD-Score:5.24|P-value:1.25E-7 ID:SGTC_2989|Compound:9073649|FD-Score:4.78|P-value:1.27E-6 ID:SGTC_3026|Compound:9090633|FD-Score:3.25|P-value:6.85E-4 ID:SGTC_3038|Compound:9091290|FD-Score:-3.32|P-value:5.89E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.35|P-value:5.27E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.68|P-value:1.63E-4 ID:SGTC_3140|Compound:9094243|FD-Score:3.21|P-value:7.73E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-3.38|P-value:4.72E-4

Top fitness defect scores for YIL101C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2651 1327-0036 9.12 5.0 µM 1.55E-19 30 3.72E-20
2 SGTC_2582 agaric acid 8.35 100.0 µM 1.17E-16 redox potentiating 97 3.55E-17
3 SGTC_2012 4023501 6.15 200.0 µM 7.27E-10 5 3.87E-10
4 SGTC_2835 9006588 5.24 71.4 µM 1.25E-7 14 7.99E-8
5 SGTC_2989 9073649 4.78 71.4 µM 1.27E-6 15 8.75E-7
6 SGTC_382 3229-0966 4.69 23.2 µM 1.91E-6 6 1.34E-6
7 SGTC_1932 st074806 4.69 40.9 µM 1.98E-6 10 1.39E-6
8 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 4.32 61.9 µM 1.04E-5 8 7.71E-6
9 SGTC_620 0109-0052 4.05 432.0 µM 3.38E-5 16 2.60E-5
10 SGTC_999 4022-0066 3.86 22.7 µM 7.27E-5 Golgi 49 5.74E-5
11 SGTC_2784 7567673 3.79 72.7 µM 9.49E-5 iron homeostasis 34 7.56E-5
12 SGTC_2791 5663188 3.73 71.4 µM 1.22E-4 RPP1 & pyrimidine depletion 26 9.77E-5
13 SGTC_1492 4158-0558 3.69 28.5 µM 1.40E-4 60S ribosome export 19 1.13E-4
14 SGTC_1550 gossypolone 3.66 36.6 µM 1.56E-4 16 1.26E-4
15 SGTC_2339 9000433 3.62 200.0 µM 1.83E-4 47 1.49E-4
16 SGTC_95 0471-0001 3.55 561.1 µM 2.35E-4 38 1.93E-4
17 SGTC_2501 sodium tetradecyl sulfate 3.53 13.4 µM 2.52E-4 48 2.07E-4
18 SGTC_1028 k015-0029 3.45 4.8 µM 3.34E-4 41 2.77E-4
19 SGTC_1934 st074720 3.44 32.6 µM 3.55E-4 82 2.95E-4
20 SGTC_2173 5763948 3.38 167.0 µM 4.40E-4 tubulin folding & SWR complex 28 3.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.256 3.71E-51 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.197 9.16E-31 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.193 2.31E-29 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.192 4.13E-29 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.188 4.46E-28 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.185 2.77E-27 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.180 9.53E-26 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.177 4.72E-25 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.175 1.88E-24 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.174 3.80E-24 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.170 2.88E-23 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.165 5.36E-22 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.161 5.34E-21 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.161 7.89E-21 YHR013C ARD1 hom Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress
0.159 2.07E-20 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p