YIL108W

Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL108W / YIL108W

Click on Significant Values for Screen Details

Top fitness defect scores for YIL108W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2764 methyldopa 4.94 94.7 µM 2.50E-8 10 3.93E-7
2 SGTC_2770 toltrazuril 4.34 17.5 µM 8.19E-7 15 7.18E-6
3 SGTC_943 3253-1379 4.12 105.0 µM 2.62E-6 24 1.89E-5
4 SGTC_865 0488-0499 3.81 301.0 µM 1.24E-5 21 6.93E-5
5 SGTC_1778 st046819 3.58 58.9 µM 3.72E-5 35 1.73E-4
6 SGTC_1224 0823-0416 3.47 294.0 µM 6.20E-5 23 2.65E-4
7 SGTC_1772 st048439 3.15 82.2 µM 2.44E-4 64 8.29E-4
8 SGTC_2608 thymoquinone 3.12 42.7 µM 2.73E-4 47 9.12E-4
9 SGTC_86 0417-1630 3.07 471.9 µM 3.26E-4 ubiquinone biosynthesis & proteasome 215 0.00106
10 SGTC_1010 4112-3296 3.06 15.2 µM 3.45E-4 61 0.00111
11 SGTC_2763 lisinopril 2.96 49.3 µM 5.04E-4 38 0.00152
12 SGTC_1186 1319-0216 2.73 26.0 µM 0.00123 86 0.00320
13 SGTC_518 1021-0119 2.66 62.6 µM 0.00157 ERG2 128 0.00393
14 SGTC_2504 purpurogallin 2.61 52.3 µM 0.00186 RPP1 & pyrimidine depletion 94 0.00453
15 SGTC_2420 aureobasidin a 2.60 50.0 nM 0.00192 144 0.00465
16 SGTC_2130 NSC 7 2.58 2.5 µM 0.00204 copper-dependent oxidative stress 141 0.00490
17 SGTC_1913 st060213 2.57 96.1 µM 0.00212 148 0.00505
18 SGTC_417 st075190 2.53 100.0 µM 0.00242 98 0.00566
19 SGTC_1877 wortmannin 2.52 25.0 µM 0.00257 205 0.00594
20 SGTC_3007 9078383 2.49 71.4 µM 0.00278 114 0.00635

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.06E-17 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.129 5.29E-14 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.122 1.27E-12 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.114 3.75E-11 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.101 3.90E-9 YBR153W RIB7 het Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
0.098 1.51E-8 YKL034W TUL1 hom Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1
0.097 1.81E-8 YLR342W-A_p YLR342W-A_p hom Putative protein of unknown function
0.090 1.99E-7 YDL108W KIN28 het Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
0.089 2.55E-7 YML066C SMA2 hom Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation
0.088 2.90E-7 YGL059W PKP2 hom Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.085 8.20E-7 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.083 1.34E-6 YOR316C-A_p YOR316C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.083 1.80E-6 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.083 1.71E-6 YIL089W YIL089W hom Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking
0.082 1.88E-6 YGR181W TIM13 hom Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane