YIL121W / QDR2

Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL121W / QDR2

Click on Significant Values for Screen Details ID:SGTC_335|Compound:4077-0256|FD-Score:2.98|P-value:7.43E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.02|P-value:6.39E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.12|P-value:4.40E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.55|P-value:8.70E-5 ID:SGTC_709|Compound:3807-1509|FD-Score:-2.99|P-value:7.87E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-3.81|P-value:2.78E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:3.23|P-value:2.82E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.47|P-value:1.07E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.45|P-value:1.16E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:6.21|P-value:2.01E-11 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.08|P-value:5.67E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:5.20|P-value:1.57E-8 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.51|P-value:9.09E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.51|P-value:8.97E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.27|P-value:2.42E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.10|P-value:5.21E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.03|P-value:6.05E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.18|P-value:3.47E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-3.33|P-value:2.13E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.40|P-value:1.64E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.21|P-value:3.09E-4 ID:SGTC_1893|Compound:st059353|FD-Score:4.29|P-value:2.47E-6 ID:SGTC_2055|Compound:5235184|FD-Score:-2.98|P-value:8.36E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.64|P-value:5.97E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-3.58|P-value:7.70E-5 ID:SGTC_2245|Compound:6637752|FD-Score:-3.23|P-value:3.21E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.75|P-value:2.13E-7 ID:SGTC_2285|Compound:7945142|FD-Score:4.24|P-value:3.20E-6 ID:SGTC_2288|Compound:7946289|FD-Score:3.44|P-value:1.21E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.18|P-value:3.45E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.60|P-value:6.32E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.97|P-value:8.44E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:5.94|P-value:1.29E-10 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.65|P-value:4.29E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.22|P-value:1.40E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:-7.27|P-value:6.54E-15 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:2.98|P-value:7.26E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.61|P-value:4.63E-7 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.52|P-value:9.91E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.03|P-value:6.12E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.64|P-value:5.94E-5 ID:SGTC_2884|Compound:9058502|FD-Score:3.07|P-value:5.25E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.02|P-value:7.09E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-5.90|P-value:2.05E-10 ID:SGTC_3029|Compound:9088683|FD-Score:-2.94|P-value:9.50E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-4.52|P-value:8.88E-7 ID:SGTC_3150|Compound:9097574|FD-Score:-3.11|P-value:5.10E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.57|P-value:8.02E-5 ID:SGTC_3343|Compound:9148379|FD-Score:3.23|P-value:2.81E-4 ID:SGTC_3352|Compound:9151559|FD-Score:2.90|P-value:9.99E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:2.98|P-value:7.43E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.02|P-value:6.39E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.12|P-value:4.40E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.55|P-value:8.70E-5 ID:SGTC_709|Compound:3807-1509|FD-Score:-2.99|P-value:7.87E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-3.81|P-value:2.78E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:3.23|P-value:2.82E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.47|P-value:1.07E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.45|P-value:1.16E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:6.21|P-value:2.01E-11 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.08|P-value:5.67E-4 ID:SGTC_1158|Compound:4092-0494|FD-Score:5.20|P-value:1.57E-8 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.51|P-value:9.09E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.51|P-value:8.97E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.27|P-value:2.42E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.10|P-value:5.21E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.03|P-value:6.05E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.18|P-value:3.47E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-3.33|P-value:2.13E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.40|P-value:1.64E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.21|P-value:3.09E-4 ID:SGTC_1893|Compound:st059353|FD-Score:4.29|P-value:2.47E-6 ID:SGTC_2055|Compound:5235184|FD-Score:-2.98|P-value:8.36E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.64|P-value:5.97E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-3.58|P-value:7.70E-5 ID:SGTC_2245|Compound:6637752|FD-Score:-3.23|P-value:3.21E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.75|P-value:2.13E-7 ID:SGTC_2285|Compound:7945142|FD-Score:4.24|P-value:3.20E-6 ID:SGTC_2288|Compound:7946289|FD-Score:3.44|P-value:1.21E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.18|P-value:3.45E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.60|P-value:6.32E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.97|P-value:8.44E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:5.94|P-value:1.29E-10 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.65|P-value:4.29E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.22|P-value:1.40E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:-7.27|P-value:6.54E-15 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:2.98|P-value:7.26E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.61|P-value:4.63E-7 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.52|P-value:9.91E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.03|P-value:6.12E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.64|P-value:5.94E-5 ID:SGTC_2884|Compound:9058502|FD-Score:3.07|P-value:5.25E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.02|P-value:7.09E-4 ID:SGTC_3025|Compound:9087895|FD-Score:-5.90|P-value:2.05E-10 ID:SGTC_3029|Compound:9088683|FD-Score:-2.94|P-value:9.50E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-4.52|P-value:8.88E-7 ID:SGTC_3150|Compound:9097574|FD-Score:-3.11|P-value:5.10E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.57|P-value:8.02E-5 ID:SGTC_3343|Compound:9148379|FD-Score:3.23|P-value:2.81E-4 ID:SGTC_3352|Compound:9151559|FD-Score:2.90|P-value:9.99E-4

Top fitness defect scores for YIL121W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1120 ficusin 6.21 1.8 µM 2.01E-11 2 2.72E-10
2 SGTC_2573 2',4'-dihydroxychalcone 5.94 15.0 µM 1.29E-10 13 1.42E-9
3 SGTC_2581 avocatin a 5.22 64.0 µM 1.40E-8 sphingolipid biosynthesis & PDR1 32 9.09E-8
4 SGTC_1158 4092-0494 5.20 91.8 µM 1.57E-8 4 1.01E-7
5 SGTC_2282 7944268 4.75 200.0 µM 2.13E-7 RPP1 & pyrimidine depletion 15 1.02E-6
6 SGTC_2636 apigenin dimethyl ether 4.61 100.0 µM 4.63E-7 26 2.04E-6
7 SGTC_1893 st059353 4.29 36.1 µM 2.47E-6 14 9.01E-6
8 SGTC_2285 7945142 4.24 200.0 µM 3.20E-6 15 1.14E-5
9 SGTC_2361 9034121 3.60 116.0 µM 6.32E-5 RSC complex & mRNA processing 26 1.61E-4
10 SGTC_1447 4239-0816 3.51 81.9 µM 8.97E-5 45 2.20E-4
11 SGTC_1222 0366-0074 3.51 1.2 µM 9.09E-5 TSC3-RPN4 29 2.23E-4
12 SGTC_1043 0916-0009 3.47 19.3 µM 1.07E-4 39 2.58E-4
13 SGTC_1085 doxorubicin 3.45 7.7 µM 1.16E-4 anthracycline transcription coupled DNA repair 34 2.77E-4
14 SGTC_2288 7946289 3.44 167.3 µM 1.21E-4 45 2.88E-4
15 SGTC_1451 4152-0210 3.27 104.0 µM 2.42E-4 52 5.33E-4
16 SGTC_3343 9148379 3.23 19.0 µM 2.81E-4 21 6.10E-4
17 SGTC_950 1165-0508 3.23 94.1 µM 2.82E-4 52 6.11E-4
18 SGTC_1734 st037168 3.21 69.4 µM 3.09E-4 59 6.62E-4
19 SGTC_2290 7904846 3.18 200.0 µM 3.45E-4 60 7.31E-4
20 SGTC_1604 st002052 3.18 72.4 µM 3.47E-4 TSC3-RPN4 49 7.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 5.99E-22 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.145 3.22E-17 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.138 9.15E-16 YDR246W-A_p YDR246W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.115 1.98E-11 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.113 5.01E-11 YDL037C BSC1 hom Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.106 8.68E-10 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.103 2.03E-9 YER093C-A AIM11 hom Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication
0.103 2.11E-9 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.099 1.07E-8 YGL062W PYC1 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication
0.093 7.93E-8 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.092 8.53E-8 YGR234W YHB1 hom Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.087 3.88E-7 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.087 4.39E-7 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.087 4.57E-7 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.086 6.90E-7 YGL136C MRM2 hom Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ