YIL123W / SIM1

Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL123W / SIM1

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:3.18|P-value:4.44E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:11.90|P-value:6.73E-36 ID:SGTC_182|Compound:3448-4371|FD-Score:3.38|P-value:2.06E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:2.98|P-value:9.30E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.06|P-value:6.86E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-3.08|P-value:5.73E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.38|P-value:2.03E-4 ID:SGTC_456|Compound:gingerol|FD-Score:4.35|P-value:2.64E-6 ID:SGTC_486|Compound:niguldipine|FD-Score:3.82|P-value:3.20E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.23|P-value:3.69E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.35|P-value:2.29E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.39|P-value:1.78E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:6.13|P-value:6.73E-11 ID:SGTC_617|Compound:3770-0098|FD-Score:3.36|P-value:2.24E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.44|P-value:1.62E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.30|P-value:3.42E-6 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.33|P-value:2.44E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:-4.39|P-value:1.91E-6 ID:SGTC_1234|Compound:0326-0494|FD-Score:-3.20|P-value:3.71E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.69|P-value:4.63E-7 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.12|P-value:4.97E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:5.31|P-value:1.36E-8 ID:SGTC_1403|Compound:3909-7815|FD-Score:-3.39|P-value:1.77E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.42|P-value:1.73E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:-3.01|P-value:7.54E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.22|P-value:5.09E-6 ID:SGTC_1613|Compound:st002381|FD-Score:3.08|P-value:6.42E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-3.32|P-value:2.35E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.05|P-value:6.54E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.14|P-value:7.49E-6 ID:SGTC_1908|Compound:st060353|FD-Score:4.32|P-value:3.11E-6 ID:SGTC_1920|Compound:st075728|FD-Score:3.28|P-value:3.03E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.12|P-value:5.44E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.75|P-value:3.36E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.80|P-value:2.52E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.24|P-value:3.21E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.35|P-value:2.26E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.74|P-value:4.65E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.24|P-value:3.46E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.44|P-value:1.57E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.16|P-value:4.85E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-3.52|P-value:1.04E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.04|P-value:7.34E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:3.18|P-value:4.44E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:11.90|P-value:6.73E-36 ID:SGTC_182|Compound:3448-4371|FD-Score:3.38|P-value:2.06E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:2.98|P-value:9.30E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.06|P-value:6.86E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-3.08|P-value:5.73E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.38|P-value:2.03E-4 ID:SGTC_456|Compound:gingerol|FD-Score:4.35|P-value:2.64E-6 ID:SGTC_486|Compound:niguldipine|FD-Score:3.82|P-value:3.20E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.23|P-value:3.69E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.35|P-value:2.29E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.39|P-value:1.78E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:6.13|P-value:6.73E-11 ID:SGTC_617|Compound:3770-0098|FD-Score:3.36|P-value:2.24E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.44|P-value:1.62E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.30|P-value:3.42E-6 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.33|P-value:2.44E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:-4.39|P-value:1.91E-6 ID:SGTC_1234|Compound:0326-0494|FD-Score:-3.20|P-value:3.71E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:4.69|P-value:4.63E-7 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.12|P-value:4.97E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:5.31|P-value:1.36E-8 ID:SGTC_1403|Compound:3909-7815|FD-Score:-3.39|P-value:1.77E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.42|P-value:1.73E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:-3.01|P-value:7.54E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.22|P-value:5.09E-6 ID:SGTC_1613|Compound:st002381|FD-Score:3.08|P-value:6.42E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-3.32|P-value:2.35E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.05|P-value:6.54E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:4.14|P-value:7.49E-6 ID:SGTC_1908|Compound:st060353|FD-Score:4.32|P-value:3.11E-6 ID:SGTC_1920|Compound:st075728|FD-Score:3.28|P-value:3.03E-4 ID:SGTC_2063|Compound:5246145|FD-Score:3.12|P-value:5.44E-4 ID:SGTC_2167|Compound:5876490|FD-Score:4.75|P-value:3.36E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.80|P-value:2.52E-7 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.24|P-value:3.21E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.35|P-value:2.26E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.74|P-value:4.65E-5 ID:SGTC_2828|Compound:7998861|FD-Score:3.24|P-value:3.46E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.44|P-value:1.57E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.16|P-value:4.85E-4 ID:SGTC_3097|Compound:9117246|FD-Score:-3.52|P-value:1.04E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.04|P-value:7.34E-4

Top fitness defect scores for YIL123W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 11.90 9.0 µM 6.73E-36 cell wall 54 8.41E-33
2 SGTC_522 1273-0010 6.13 11.6 µM 6.73E-11 60S ribosome export 3 4.44E-10
3 SGTC_1395 3486-0190 5.31 4.3 µM 1.36E-8 2 5.58E-8
4 SGTC_2582 agaric acid 4.80 100.0 µM 2.52E-7 redox potentiating 235 8.02E-7
5 SGTC_2167 5876490 4.75 200.0 µM 3.36E-7 13 1.04E-6
6 SGTC_1388 3346-4487 4.69 254.0 µM 4.63E-7 9 1.39E-6
7 SGTC_456 gingerol 4.35 170.0 µM 2.64E-6 11 6.83E-6
8 SGTC_1908 st060353 4.32 56.5 µM 3.11E-6 RPP1 & pyrimidine depletion 27 7.94E-6
9 SGTC_1045 1348-1485 4.30 165.0 µM 3.42E-6 21 8.65E-6
10 SGTC_1466 k213-0079 4.22 57.5 µM 5.09E-6 11 1.24E-5
11 SGTC_1869 3',7'-dimethoxyflavone 4.14 40.3 µM 7.49E-6 20 1.77E-5
12 SGTC_486 niguldipine 3.82 82.0 µM 3.20E-5 amide catabolism 17 6.67E-5
13 SGTC_2797 7859098 3.74 81.8 µM 4.65E-5 31 9.38E-5
14 SGTC_2944 9067346 3.44 25.6 µM 1.57E-4 48 2.86E-4
15 SGTC_892 0929-0076 3.44 29.0 µM 1.62E-4 TRP & mitochondrial translation 65 2.93E-4
16 SGTC_1409 3909-8004 3.42 61.9 µM 1.73E-4 41 3.12E-4
17 SGTC_255 tunicamycin 3.38 200.5 nM 2.03E-4 unfolded protein response 100 3.61E-4
18 SGTC_182 3448-4371 3.38 550.5 µM 2.06E-4 42 3.66E-4
19 SGTC_617 3770-0098 3.36 35.0 µM 2.24E-4 exosome 28 3.95E-4
20 SGTC_2702 st077768 3.35 96.8 µM 2.26E-4 37 3.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.365 1.92E-106 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.325 2.47E-83 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.308 9.22E-75 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.305 2.71E-73 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.279 4.27E-61 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.277 8.28E-60 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.269 7.85E-57 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.268 2.85E-56 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.264 1.11E-54 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.261 1.92E-53 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.259 1.05E-52 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.257 1.18E-51 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.256 3.27E-51 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.255 6.64E-51 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.241 1.26E-45 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C