YIL124W / AYR1

NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL124W / AYR1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.18|P-value:1.37E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.11|P-value:9.19E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.61|P-value:1.83E-6 ID:SGTC_271|Compound:rotenone|FD-Score:4.66|P-value:1.43E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:-3.43|P-value:2.72E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.76|P-value:7.94E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:4.44|P-value:4.23E-6 ID:SGTC_487|Compound:nimodipine|FD-Score:3.94|P-value:3.91E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.09|P-value:2.03E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.15|P-value:7.60E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.23|P-value:5.99E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.46|P-value:2.63E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.23|P-value:5.87E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.07|P-value:9.87E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.81|P-value:6.46E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-3.39|P-value:3.25E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.77|P-value:8.21E-7 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.62|P-value:1.77E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:4.60|P-value:1.95E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.32|P-value:4.09E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.49|P-value:2.28E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.50|P-value:2.24E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.95|P-value:3.69E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.48|P-value:2.36E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.74|P-value:8.29E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.34|P-value:4.02E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:4.41|P-value:4.72E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.89|P-value:4.71E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:7.88|P-value:1.19E-15 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.70|P-value:9.72E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.84|P-value:5.75E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-3.23|P-value:5.73E-4 ID:SGTC_1893|Compound:st059353|FD-Score:6.11|P-value:4.13E-10 ID:SGTC_1981|Compound:st071826|FD-Score:3.09|P-value:9.52E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.74|P-value:9.77E-7 ID:SGTC_2040|Compound:5100729|FD-Score:7.48|P-value:2.93E-14 ID:SGTC_2284|Compound:7945075|FD-Score:3.17|P-value:7.24E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.09|P-value:9.78E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-4.23|P-value:1.02E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-6.25|P-value:1.64E-10 ID:SGTC_2301|Compound:7769476|FD-Score:3.25|P-value:5.48E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.89|P-value:4.71E-5 ID:SGTC_2358|Compound:9037157|FD-Score:4.15|P-value:1.54E-5 ID:SGTC_2361|Compound:9034121|FD-Score:-4.05|P-value:2.24E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-4.98|P-value:2.63E-7 ID:SGTC_2425|Compound:5628681|FD-Score:3.75|P-value:8.33E-5 ID:SGTC_2427|Compound:5545055|FD-Score:4.30|P-value:7.80E-6 ID:SGTC_2439|Compound:5492030|FD-Score:3.66|P-value:1.21E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.77|P-value:7.76E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.09|P-value:9.28E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.52|P-value:2.05E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.81|P-value:3.15E-23 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.48|P-value:1.87E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.35|P-value:6.41E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:3.41|P-value:3.09E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.66|P-value:1.21E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.19|P-value:6.78E-4 ID:SGTC_2918|Compound:7977171|FD-Score:4.15|P-value:1.56E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.66|P-value:1.15E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-4.06|P-value:2.15E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-3.09|P-value:9.23E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.23|P-value:6.05E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.30|P-value:4.72E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.40|P-value:3.19E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:4.18|P-value:1.37E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.11|P-value:9.19E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.61|P-value:1.83E-6 ID:SGTC_271|Compound:rotenone|FD-Score:4.66|P-value:1.43E-6 ID:SGTC_373|Compound:0844-0104|FD-Score:-3.43|P-value:2.72E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.76|P-value:7.94E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:4.44|P-value:4.23E-6 ID:SGTC_487|Compound:nimodipine|FD-Score:3.94|P-value:3.91E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.09|P-value:2.03E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.15|P-value:7.60E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.23|P-value:5.99E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.46|P-value:2.63E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.23|P-value:5.87E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.07|P-value:9.87E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.81|P-value:6.46E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-3.39|P-value:3.25E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.77|P-value:8.21E-7 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.62|P-value:1.77E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:4.60|P-value:1.95E-6 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.32|P-value:4.09E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.49|P-value:2.28E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.50|P-value:2.24E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.95|P-value:3.69E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.48|P-value:2.36E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-3.74|P-value:8.29E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.34|P-value:4.02E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:4.41|P-value:4.72E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.89|P-value:4.71E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:7.88|P-value:1.19E-15 ID:SGTC_1325|Compound:1431-0015|FD-Score:-3.70|P-value:9.72E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.84|P-value:5.75E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-3.23|P-value:5.73E-4 ID:SGTC_1893|Compound:st059353|FD-Score:6.11|P-value:4.13E-10 ID:SGTC_1981|Compound:st071826|FD-Score:3.09|P-value:9.52E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.74|P-value:9.77E-7 ID:SGTC_2040|Compound:5100729|FD-Score:7.48|P-value:2.93E-14 ID:SGTC_2284|Compound:7945075|FD-Score:3.17|P-value:7.24E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.09|P-value:9.78E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-4.23|P-value:1.02E-5 ID:SGTC_2300|Compound:7976697|FD-Score:-6.25|P-value:1.64E-10 ID:SGTC_2301|Compound:7769476|FD-Score:3.25|P-value:5.48E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.89|P-value:4.71E-5 ID:SGTC_2358|Compound:9037157|FD-Score:4.15|P-value:1.54E-5 ID:SGTC_2361|Compound:9034121|FD-Score:-4.05|P-value:2.24E-5 ID:SGTC_2363|Compound:9053361|FD-Score:-4.98|P-value:2.63E-7 ID:SGTC_2425|Compound:5628681|FD-Score:3.75|P-value:8.33E-5 ID:SGTC_2427|Compound:5545055|FD-Score:4.30|P-value:7.80E-6 ID:SGTC_2439|Compound:5492030|FD-Score:3.66|P-value:1.21E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.77|P-value:7.76E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.09|P-value:9.28E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.52|P-value:2.05E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.81|P-value:3.15E-23 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.48|P-value:1.87E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.35|P-value:6.41E-6 ID:SGTC_2730|Compound:imipramine|FD-Score:3.41|P-value:3.09E-4 ID:SGTC_2812|Compound:7970281|FD-Score:3.66|P-value:1.21E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.19|P-value:6.78E-4 ID:SGTC_2918|Compound:7977171|FD-Score:4.15|P-value:1.56E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.66|P-value:1.15E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-4.06|P-value:2.15E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-3.09|P-value:9.23E-4 ID:SGTC_2976|Compound:9009005|FD-Score:3.23|P-value:6.05E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.30|P-value:4.72E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.40|P-value:3.19E-4

Top fitness defect scores for YIL124W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 9.81 100.0 µM 3.15E-23 redox potentiating 67 4.95E-23
2 SGTC_1309 pyrazolanthrone 7.88 13.4 µM 1.19E-15 5 1.59E-15
3 SGTC_2040 5100729 7.48 123.0 µM 2.93E-14 5 3.78E-14
4 SGTC_1893 st059353 6.11 36.1 µM 4.13E-10 3 4.87E-10
5 SGTC_2651 1327-0036 5.48 5.0 µM 1.87E-8 91 2.13E-8
6 SGTC_919 tnp00227 4.77 403.6 nM 8.21E-7 RNA pol III & RNase P/MRP 16 9.02E-7
7 SGTC_2016 5121758 4.74 140.0 µM 9.77E-7 redox potentiating 22 1.07E-6
8 SGTC_271 rotenone 4.66 740.0 µM 1.43E-6 12 1.56E-6
9 SGTC_920 mycophenolic acid 4.62 780.4 nM 1.77E-6 14 1.93E-6
10 SGTC_163 1327-0036 4.61 7.5 µM 1.83E-6 79 1.99E-6
11 SGTC_953 1188-0045 4.60 9.7 µM 1.95E-6 60S ribosome export 13 2.13E-6
12 SGTC_386 1509-0011 4.44 3.1 µM 4.23E-6 124 4.58E-6
13 SGTC_1118 chelidonine 4.41 707.5 nM 4.72E-6 13 5.10E-6
14 SGTC_2688 kanamycin b 4.35 96.7 µM 6.41E-6 calcium & mitochondrial duress 318 6.92E-6
15 SGTC_2427 5545055 4.30 42.8 µM 7.80E-6 8 8.41E-6
16 SGTC_8 0354-0001 4.18 70.0 µM 1.37E-5 72 1.47E-5
17 SGTC_2358 9037157 4.15 4.0 µM 1.54E-5 25 1.65E-5
18 SGTC_2918 7977171 4.15 22.1 µM 1.56E-5 25 1.67E-5
19 SGTC_514 4466-0038 4.09 2.6 nM 2.03E-5 cell wall 144 2.17E-5
20 SGTC_1031 k035-0009 3.95 16.0 µM 3.69E-5 31 3.92E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.351 6.41E-98 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.296 7.49E-69 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.267 6.03E-56 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.234 7.93E-43 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.232 2.63E-42 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.231 1.08E-41 YIL057C RGI2 hom Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose
0.220 3.78E-38 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.211 3.36E-35 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.211 4.04E-35 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.207 6.34E-34 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.201 8.38E-32 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.192 3.08E-29 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.189 1.97E-28 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.183 1.27E-26 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.181 5.01E-26 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p