YIL156W / UBP7

Ubiquitin-specific protease that cleaves ubiquitin-protein fusions

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL156W / UBP7

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:3.39|P-value:3.62E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.40|P-value:3.09E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.34|P-value:4.42E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.84|P-value:5.59E-5 ID:SGTC_324|Compound:1315-0088|FD-Score:4.14|P-value:1.78E-5 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.37|P-value:3.93E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.47|P-value:2.69E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.44|P-value:3.07E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.14|P-value:1.45E-7 ID:SGTC_880|Compound:0833-0487|FD-Score:3.52|P-value:2.22E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.66|P-value:1.35E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.74|P-value:8.29E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.62|P-value:2.01E-6 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.41|P-value:2.96E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.38|P-value:3.76E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.32|P-value:4.77E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.49|P-value:2.55E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.32|P-value:4.07E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.11|P-value:9.61E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.19|P-value:7.33E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.22|P-value:6.72E-4 ID:SGTC_2025|Compound:5147754|FD-Score:3.12|P-value:9.37E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.14|P-value:8.86E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.47|P-value:2.40E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.57|P-value:1.84E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.10|P-value:9.07E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.46|P-value:2.88E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.98|P-value:3.64E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-4.41|P-value:4.69E-6 ID:SGTC_2368|Compound:9071271|FD-Score:5.34|P-value:4.79E-8 ID:SGTC_2395|Compound:5646831|FD-Score:-3.30|P-value:4.41E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.59|P-value:1.70E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:-3.99|P-value:3.00E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.39|P-value:3.60E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.77|P-value:8.41E-5 ID:SGTC_2944|Compound:9067346|FD-Score:4.81|P-value:8.09E-7 ID:SGTC_3150|Compound:9097574|FD-Score:-4.32|P-value:6.83E-6 ID:SGTC_3154|Compound:9100113|FD-Score:-5.52|P-value:1.43E-8 ID:SGTC_3213|Compound:9129884|FD-Score:3.25|P-value:6.05E-4 ID:SGTC_3310|Compound:9130229|FD-Score:4.19|P-value:1.44E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.39|P-value:3.62E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.40|P-value:3.09E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.34|P-value:4.42E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:-3.84|P-value:5.59E-5 ID:SGTC_324|Compound:1315-0088|FD-Score:4.14|P-value:1.78E-5 ID:SGTC_466|Compound:geldanamycin|FD-Score:3.37|P-value:3.93E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.47|P-value:2.69E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.44|P-value:3.07E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.14|P-value:1.45E-7 ID:SGTC_880|Compound:0833-0487|FD-Score:3.52|P-value:2.22E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.66|P-value:1.35E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.74|P-value:8.29E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.62|P-value:2.01E-6 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.41|P-value:2.96E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.38|P-value:3.76E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.32|P-value:4.77E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.49|P-value:2.55E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.32|P-value:4.07E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.11|P-value:9.61E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.19|P-value:7.33E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.22|P-value:6.72E-4 ID:SGTC_2025|Compound:5147754|FD-Score:3.12|P-value:9.37E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.14|P-value:8.86E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.47|P-value:2.40E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.57|P-value:1.84E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.10|P-value:9.07E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.46|P-value:2.88E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.98|P-value:3.64E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-4.41|P-value:4.69E-6 ID:SGTC_2368|Compound:9071271|FD-Score:5.34|P-value:4.79E-8 ID:SGTC_2395|Compound:5646831|FD-Score:-3.30|P-value:4.41E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.59|P-value:1.70E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:-3.99|P-value:3.00E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.39|P-value:3.60E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.77|P-value:8.41E-5 ID:SGTC_2944|Compound:9067346|FD-Score:4.81|P-value:8.09E-7 ID:SGTC_3150|Compound:9097574|FD-Score:-4.32|P-value:6.83E-6 ID:SGTC_3154|Compound:9100113|FD-Score:-5.52|P-value:1.43E-8 ID:SGTC_3213|Compound:9129884|FD-Score:3.25|P-value:6.05E-4 ID:SGTC_3310|Compound:9130229|FD-Score:4.19|P-value:1.44E-5

Top fitness defect scores for YIL156W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2368 9071271 5.34 200.0 µM 4.79E-8 7 4.56E-8
2 SGTC_576 1073-0113 5.14 22.7 µM 1.45E-7 redox potentiating 33 1.38E-7
3 SGTC_2944 9067346 4.81 25.6 µM 8.09E-7 12 7.70E-7
4 SGTC_1054 3429-0080 4.62 167.0 µM 2.01E-6 21 1.91E-6
5 SGTC_3310 9130229 4.19 44.1 µM 1.44E-5 Golgi 19 1.37E-5
6 SGTC_324 1315-0088 4.14 19.6 µM 1.78E-5 RSC & ERG11 8 1.70E-5
7 SGTC_2361 9034121 3.98 116.0 µM 3.64E-5 RSC complex & mRNA processing 19 3.47E-5
8 SGTC_2786 7743617 3.77 45.5 µM 8.41E-5 31 8.04E-5
9 SGTC_887 0885-0007 3.66 9.6 µM 1.35E-4 endomembrane recycling 41 1.29E-4
10 SGTC_2596 sinensetin 3.59 100.0 µM 1.70E-4 46 1.62E-4
11 SGTC_2261 9010538 3.57 184.7 µM 1.84E-4 28 1.76E-4
12 SGTC_880 0833-0487 3.52 87.2 µM 2.22E-4 mitochondrial processes 22 2.12E-4
13 SGTC_1189 1431-2119 3.49 7.3 µM 2.55E-4 48 2.44E-4
14 SGTC_474 dl-dihydrosphingosine 3.47 5.0 µM 2.69E-4 46 2.57E-4
15 SGTC_2351 9026858 3.46 72.3 µM 2.88E-4 RNA processing & uracil transport 39 2.75E-4
16 SGTC_545 4218-0007 3.44 221.0 µM 3.07E-4 44 2.94E-4
17 SGTC_2742 clothiapine 3.39 36.3 µM 3.60E-4 NEO1 31 3.44E-4
18 SGTC_77 0828-0286 3.39 12.5 µM 3.62E-4 TSC3-RPN4 62 3.46E-4
19 SGTC_1151 3909-8316 3.38 15.3 µM 3.76E-4 36 3.59E-4
20 SGTC_466 geldanamycin 3.37 89.2 µM 3.93E-4 RPP1 & pyrimidine depletion 17 3.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 8.50E-11 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.086 6.09E-7 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.081 2.55E-6 YOR217W RFC1 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.078 6.73E-6 YLR108C YLR108C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication
0.077 7.36E-6 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.077 7.91E-6 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.073 2.35E-5 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.072 3.20E-5 YIL044C AGE2 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
0.072 3.37E-5 YBR021W FUR4 hom Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
0.071 4.10E-5 YGR224W AZR1 hom Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole
0.070 4.97E-5 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.069 6.00E-5 YOR360C PDE2 hom High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
0.069 6.30E-5 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.067 9.94E-5 YKR104W YKR104W hom Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds
0.066 1.29E-4 YBL083C_d YBL083C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3