YIL157C / COA1

Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL157C / COA1

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:3.12|P-value:7.50E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-4.02|P-value:1.74E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:3.87|P-value:3.93E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:3.97|P-value:2.57E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:4.15|P-value:1.15E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.30|P-value:3.35E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.46|P-value:2.08E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.25|P-value:4.59E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.03|P-value:1.21E-20 ID:SGTC_290|Compound:2043-6722|FD-Score:3.74|P-value:6.97E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:3.71|P-value:7.91E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.15|P-value:6.68E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.70|P-value:8.17E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.69|P-value:8.31E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.13|P-value:6.17E-4 ID:SGTC_446|Compound:go6976|FD-Score:-3.39|P-value:2.38E-4 ID:SGTC_469|Compound:w7|FD-Score:3.83|P-value:4.79E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:3.32|P-value:3.53E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.46|P-value:2.08E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.58|P-value:1.30E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.66|P-value:9.39E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.51|P-value:1.77E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.07|P-value:8.96E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.24|P-value:7.58E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.16|P-value:6.49E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.27|P-value:6.69E-6 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.17|P-value:6.32E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:5.75|P-value:2.11E-9 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.55|P-value:1.48E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.85|P-value:4.27E-5 ID:SGTC_1438|Compound:4092-1045|FD-Score:5.07|P-value:1.13E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.17|P-value:6.55E-8 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.48|P-value:2.38E-6 ID:SGTC_1629|Compound:st005085|FD-Score:3.62|P-value:1.12E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.42|P-value:3.20E-6 ID:SGTC_1648|Compound:st011736|FD-Score:3.17|P-value:6.11E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.84|P-value:4.45E-5 ID:SGTC_1899|Compound:st063254|FD-Score:4.44|P-value:2.91E-6 ID:SGTC_1922|Compound:5578187|FD-Score:3.29|P-value:3.96E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.05|P-value:9.58E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.56|P-value:1.44E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.87|P-value:3.34E-5 ID:SGTC_2146|Compound:5545642|FD-Score:3.81|P-value:5.07E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.35|P-value:3.24E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.52|P-value:1.65E-4 ID:SGTC_2263|Compound:7948595|FD-Score:4.16|P-value:1.11E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-4.01|P-value:1.77E-5 ID:SGTC_2297|Compound:7971671|FD-Score:-3.45|P-value:1.87E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.26|P-value:4.45E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-4.06|P-value:1.41E-5 ID:SGTC_2321|Compound:7390090|FD-Score:6.25|P-value:8.43E-11 ID:SGTC_2334|Compound:9017922|FD-Score:5.01|P-value:1.59E-7 ID:SGTC_2366|Compound:9070441|FD-Score:3.17|P-value:6.18E-4 ID:SGTC_2455|Compound:5377712|FD-Score:4.23|P-value:7.95E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.88|P-value:3.07E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.95|P-value:2.82E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.88|P-value:3.73E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:4.10|P-value:1.47E-5 ID:SGTC_2719|Compound:novobiocin|FD-Score:4.48|P-value:2.45E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.34|P-value:4.68E-6 ID:SGTC_2831|Compound:7999036|FD-Score:4.09|P-value:1.51E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.71|P-value:6.48E-5 ID:SGTC_2846|Compound:9008642|FD-Score:-3.75|P-value:5.45E-5 ID:SGTC_2880|Compound:9042983|FD-Score:-3.00|P-value:9.64E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.80|P-value:5.35E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.09|P-value:1.24E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.56|P-value:1.42E-4 ID:SGTC_3148|Compound:9097893|FD-Score:5.34|P-value:2.50E-8 ID:SGTC_3263|Compound:9137018|FD-Score:6.00|P-value:4.26E-10 ID:SGTC_3264|Compound:9137442|FD-Score:3.49|P-value:1.88E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.12|P-value:7.50E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-4.02|P-value:1.74E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:3.87|P-value:3.93E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:3.97|P-value:2.57E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:4.15|P-value:1.15E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.30|P-value:3.35E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.46|P-value:2.08E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.25|P-value:4.59E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:9.03|P-value:1.21E-20 ID:SGTC_290|Compound:2043-6722|FD-Score:3.74|P-value:6.97E-5 ID:SGTC_371|Compound:0195-0006|FD-Score:3.71|P-value:7.91E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.15|P-value:6.68E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.70|P-value:8.17E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.69|P-value:8.31E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.13|P-value:6.17E-4 ID:SGTC_446|Compound:go6976|FD-Score:-3.39|P-value:2.38E-4 ID:SGTC_469|Compound:w7|FD-Score:3.83|P-value:4.79E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:3.32|P-value:3.53E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.46|P-value:2.08E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.58|P-value:1.30E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.66|P-value:9.39E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.51|P-value:1.77E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.07|P-value:8.96E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.24|P-value:7.58E-6 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.16|P-value:6.49E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.27|P-value:6.69E-6 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.17|P-value:6.32E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:5.75|P-value:2.11E-9 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.55|P-value:1.48E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.85|P-value:4.27E-5 ID:SGTC_1438|Compound:4092-1045|FD-Score:5.07|P-value:1.13E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.17|P-value:6.55E-8 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:4.48|P-value:2.38E-6 ID:SGTC_1629|Compound:st005085|FD-Score:3.62|P-value:1.12E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.42|P-value:3.20E-6 ID:SGTC_1648|Compound:st011736|FD-Score:3.17|P-value:6.11E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.84|P-value:4.45E-5 ID:SGTC_1899|Compound:st063254|FD-Score:4.44|P-value:2.91E-6 ID:SGTC_1922|Compound:5578187|FD-Score:3.29|P-value:3.96E-4 ID:SGTC_1969|Compound:st069479|FD-Score:3.05|P-value:9.58E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.56|P-value:1.44E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.87|P-value:3.34E-5 ID:SGTC_2146|Compound:5545642|FD-Score:3.81|P-value:5.07E-5 ID:SGTC_2163|Compound:5671233|FD-Score:3.35|P-value:3.24E-4 ID:SGTC_2197|Compound:6588183|FD-Score:3.52|P-value:1.65E-4 ID:SGTC_2263|Compound:7948595|FD-Score:4.16|P-value:1.11E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-4.01|P-value:1.77E-5 ID:SGTC_2297|Compound:7971671|FD-Score:-3.45|P-value:1.87E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.26|P-value:4.45E-4 ID:SGTC_2317|Compound:5986382|FD-Score:-4.06|P-value:1.41E-5 ID:SGTC_2321|Compound:7390090|FD-Score:6.25|P-value:8.43E-11 ID:SGTC_2334|Compound:9017922|FD-Score:5.01|P-value:1.59E-7 ID:SGTC_2366|Compound:9070441|FD-Score:3.17|P-value:6.18E-4 ID:SGTC_2455|Compound:5377712|FD-Score:4.23|P-value:7.95E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.88|P-value:3.07E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.95|P-value:2.82E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.88|P-value:3.73E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:4.10|P-value:1.47E-5 ID:SGTC_2719|Compound:novobiocin|FD-Score:4.48|P-value:2.45E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.34|P-value:4.68E-6 ID:SGTC_2831|Compound:7999036|FD-Score:4.09|P-value:1.51E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.71|P-value:6.48E-5 ID:SGTC_2846|Compound:9008642|FD-Score:-3.75|P-value:5.45E-5 ID:SGTC_2880|Compound:9042983|FD-Score:-3.00|P-value:9.64E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.80|P-value:5.35E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.09|P-value:1.24E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.56|P-value:1.42E-4 ID:SGTC_3148|Compound:9097893|FD-Score:5.34|P-value:2.50E-8 ID:SGTC_3263|Compound:9137018|FD-Score:6.00|P-value:4.26E-10 ID:SGTC_3264|Compound:9137442|FD-Score:3.49|P-value:1.88E-4

Top fitness defect scores for YIL157C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.03 5.3 µM 1.21E-20 218 8.28E-20
2 SGTC_2321 7390090 6.25 138.8 µM 8.43E-11 4 2.05E-10
3 SGTC_3263 9137018 6.00 49.5 µM 4.26E-10 1 9.62E-10
4 SGTC_1331 1472-0049 5.75 76.2 µM 2.11E-9 2 4.43E-9
5 SGTC_3148 9097893 5.34 49.5 µM 2.50E-8 18 4.72E-8
6 SGTC_1468 k284-1086 5.17 134.0 µM 6.55E-8 DNA intercalators 9 1.18E-7
7 SGTC_1438 4092-1045 5.07 4.0 µM 1.13E-7 1 1.99E-7
8 SGTC_2334 9017922 5.01 200.0 µM 1.59E-7 6 2.77E-7
9 SGTC_2472 5377652 4.88 49.4 µM 3.07E-7 TRP & mitochondrial translation 33 5.18E-7
10 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 4.48 61.9 µM 2.38E-6 5 3.68E-6
11 SGTC_2719 novobiocin 4.48 32.6 µM 2.45E-6 2 3.79E-6
12 SGTC_1899 st063254 4.44 59.6 µM 2.91E-6 7 4.46E-6
13 SGTC_1635 st007035 4.42 42.4 µM 3.20E-6 189 4.88E-6
14 SGTC_2753 fluvastatin 4.34 17.1 µM 4.68E-6 azole & statin 24 7.02E-6
15 SGTC_1211 1056-0033 4.27 32.3 µM 6.69E-6 6 9.90E-6
16 SGTC_1160 4092-0570 4.24 10.5 µM 7.58E-6 plasma membrane duress 33 1.12E-5
17 SGTC_2455 5377712 4.23 9.8 µM 7.95E-6 18 1.17E-5
18 SGTC_2263 7948595 4.16 193.3 µM 1.11E-5 2 1.61E-5
19 SGTC_100 0086-0128 4.15 49.6 µM 1.15E-5 copper-dependent oxidative stress 45 1.66E-5
20 SGTC_2544 sphondin 4.10 68.5 µM 1.47E-5 RNA pol III & RNase P/MRP 24 2.10E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.275 2.08E-59 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.272 5.03E-58 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.265 3.46E-55 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.262 9.10E-54 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.260 7.63E-53 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.260 9.99E-53 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.248 3.96E-48 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.243 3.66E-46 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.240 2.35E-45 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.240 3.94E-45 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.240 5.18E-45 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.237 5.23E-44 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.237 6.15E-44 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.236 1.11E-43 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.235 1.96E-43 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20