YIL159W / BNR1

Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL159W / BNR1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.41|P-value:3.76E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:4.12|P-value:1.45E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:3.87|P-value:4.29E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:3.22|P-value:5.33E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.35|P-value:3.34E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.16|P-value:6.54E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.05|P-value:9.65E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.26|P-value:4.66E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:-3.15|P-value:7.04E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.25|P-value:4.75E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.17|P-value:1.13E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:-4.44|P-value:3.48E-6 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.05|P-value:9.62E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.51|P-value:1.81E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:-3.11|P-value:8.10E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.62|P-value:1.21E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.99|P-value:2.64E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.10|P-value:8.21E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.14|P-value:6.95E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.07|P-value:9.45E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.38|P-value:2.98E-4 ID:SGTC_1905|Compound:st060207|FD-Score:4.16|P-value:1.18E-5 ID:SGTC_2015|Compound:5119600|FD-Score:-3.53|P-value:1.76E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.27|P-value:4.44E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.07|P-value:9.02E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.76|P-value:6.77E-5 ID:SGTC_2038|Compound:4100038|FD-Score:4.19|P-value:1.01E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.25|P-value:4.79E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.90|P-value:3.99E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.46|P-value:2.22E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.13|P-value:7.34E-4 ID:SGTC_2793|Compound:7325131|FD-Score:5.39|P-value:2.15E-8 ID:SGTC_2833|Compound:9001315|FD-Score:3.04|P-value:9.88E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.28|P-value:4.23E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.11|P-value:7.84E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.25|P-value:4.91E-4 ID:SGTC_3220|Compound:9131269|FD-Score:7.61|P-value:5.48E-15 ID:SGTC_3222|Compound:9128301|FD-Score:3.93|P-value:3.19E-5 ID:SGTC_3299|Compound:9121982|FD-Score:3.20|P-value:5.71E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.41|P-value:3.76E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:4.12|P-value:1.45E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:3.87|P-value:4.29E-5 ID:SGTC_721|Compound:1187-1332|FD-Score:3.22|P-value:5.33E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:3.35|P-value:3.34E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.16|P-value:6.54E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.05|P-value:9.65E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.26|P-value:4.66E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:-3.15|P-value:7.04E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.25|P-value:4.75E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:4.17|P-value:1.13E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:-4.44|P-value:3.48E-6 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.05|P-value:9.62E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.51|P-value:1.81E-4 ID:SGTC_1296|Compound:1068-0102|FD-Score:-3.11|P-value:8.10E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.62|P-value:1.21E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.99|P-value:2.64E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.10|P-value:8.21E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.14|P-value:6.95E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.07|P-value:9.45E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.38|P-value:2.98E-4 ID:SGTC_1905|Compound:st060207|FD-Score:4.16|P-value:1.18E-5 ID:SGTC_2015|Compound:5119600|FD-Score:-3.53|P-value:1.76E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.27|P-value:4.44E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.07|P-value:9.02E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.76|P-value:6.77E-5 ID:SGTC_2038|Compound:4100038|FD-Score:4.19|P-value:1.01E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:3.25|P-value:4.79E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.90|P-value:3.99E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.46|P-value:2.22E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.13|P-value:7.34E-4 ID:SGTC_2793|Compound:7325131|FD-Score:5.39|P-value:2.15E-8 ID:SGTC_2833|Compound:9001315|FD-Score:3.04|P-value:9.88E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.28|P-value:4.23E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.11|P-value:7.84E-4 ID:SGTC_3007|Compound:9078383|FD-Score:-3.25|P-value:4.91E-4 ID:SGTC_3220|Compound:9131269|FD-Score:7.61|P-value:5.48E-15 ID:SGTC_3222|Compound:9128301|FD-Score:3.93|P-value:3.19E-5 ID:SGTC_3299|Compound:9121982|FD-Score:3.20|P-value:5.71E-4

Top fitness defect scores for YIL159W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3220 9131269 7.61 49.5 µM 5.48E-15 1 1.36E-14
2 SGTC_2793 7325131 5.39 81.8 µM 2.15E-8 7 3.45E-8
3 SGTC_58 0957-0393 4.41 9.0 µM 3.76E-6 cell wall 334 5.21E-6
4 SGTC_2038 4100038 4.19 31.0 µM 1.01E-5 plasma membrane duress 42 1.37E-5
5 SGTC_1257 0669-0121 4.17 16.0 µM 1.13E-5 21 1.51E-5
6 SGTC_1905 st060207 4.16 84.5 µM 1.18E-5 7 1.58E-5
7 SGTC_367 0335-0881 4.12 7.1 µM 1.45E-5 ubiquinone biosynthesis & proteasome 71 1.93E-5
8 SGTC_3222 9128301 3.93 49.5 µM 3.19E-5 60S ribosome export 26 4.16E-5
9 SGTC_705 1124-0212 3.87 310.0 µM 4.29E-5 17 5.55E-5
10 SGTC_2030 5175110 3.76 200.0 µM 6.77E-5 Golgi 28 8.64E-5
11 SGTC_1266 0828-0227 3.51 32.9 µM 1.81E-4 31 2.25E-4
12 SGTC_2309 7664088 3.46 163.9 µM 2.22E-4 65 2.74E-4
13 SGTC_1889 st059080 3.38 5.2 µM 2.98E-4 41 3.65E-4
14 SGTC_823 0417-1665 3.35 178.0 µM 3.34E-4 58 4.08E-4
15 SGTC_2975 9084847 3.28 53.7 µM 4.23E-4 53 5.12E-4
16 SGTC_2017 5132927 3.27 60.6 µM 4.44E-4 60 5.37E-4
17 SGTC_1090 efavirenz 3.26 20.7 µM 4.66E-4 47 5.64E-4
18 SGTC_1185 1319-0113 3.25 81.3 µM 4.75E-4 DNA damage response 27 5.74E-4
19 SGTC_2039 Aminomethylbenzodioxan 3.25 200.0 µM 4.79E-4 19 5.79E-4
20 SGTC_721 1187-1332 3.22 279.0 µM 5.33E-4 cell wall signaling 31 6.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 6.83E-17 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.139 7.07E-16 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.138 8.75E-16 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.135 4.67E-15 YPR008W HAA1 hom Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress
0.134 7.27E-15 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.127 1.40E-13 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.122 1.45E-12 YBR146W MRPS9 hom Mitochondrial ribosomal protein of the small subunit
0.113 4.94E-11 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.113 5.73E-11 YMR030W RSF1 hom Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes
0.110 1.48E-10 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.107 4.45E-10 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.106 7.86E-10 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.103 2.10E-9 YDL162C_d YDL162C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
0.102 3.72E-9 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.101 4.92E-9 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization