YIL163C_p

Protein of unknown function; mRNA identified as translated by ribosome profiling data

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL163C / YIL163C

Click on Significant Values for Screen Details ID:SGTC_161|Compound:4065-0411|FD-Score:4.96|P-value:5.57E-8 ID:SGTC_393|Compound:acivicin|FD-Score:3.05|P-value:5.68E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.86|P-value:1.74E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:2.97|P-value:7.50E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.00|P-value:6.80E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.10|P-value:4.61E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.12|P-value:3.99E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.51|P-value:8.81E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:3.96|P-value:1.19E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:4.96|P-value:5.66E-8 ID:SGTC_795|Compound:0685-0265|FD-Score:-2.96|P-value:7.33E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:-2.90|P-value:9.29E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.52|P-value:8.43E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:3.54|P-value:7.88E-5 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.10|P-value:4.66E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.92|P-value:9.25E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.84|P-value:2.02E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.00|P-value:6.24E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.46|P-value:1.11E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.43|P-value:1.22E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.15|P-value:3.78E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:4.35|P-value:1.64E-6 ID:SGTC_1553|Compound:gossypol|FD-Score:3.87|P-value:1.74E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.82|P-value:2.02E-5 ID:SGTC_2005|Compound:4024620|FD-Score:3.72|P-value:3.55E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.26|P-value:2.49E-4 ID:SGTC_2079|Compound:5212404|FD-Score:4.80|P-value:1.46E-7 ID:SGTC_2085|Compound:5307070|FD-Score:-4.23|P-value:2.84E-6 ID:SGTC_2087|Compound:5276107|FD-Score:2.90|P-value:9.73E-4 ID:SGTC_2248|Compound:tofa|FD-Score:5.14|P-value:1.90E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.13|P-value:3.91E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:4.90|P-value:7.95E-8 ID:SGTC_2318|Compound:6029776|FD-Score:4.70|P-value:2.60E-7 ID:SGTC_2320|Compound:7373003|FD-Score:6.24|P-value:1.24E-11 ID:SGTC_2321|Compound:7390090|FD-Score:-2.91|P-value:8.80E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.36|P-value:1.67E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.10|P-value:2.45E-8 ID:SGTC_2556|Compound:citropten|FD-Score:6.88|P-value:9.01E-14 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.64|P-value:4.65E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-5.19|P-value:1.25E-8 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.15|P-value:3.81E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.52|P-value:8.38E-5 ID:SGTC_2807|Compound:7945238|FD-Score:5.15|P-value:1.82E-8 ID:SGTC_2809|Compound:7964133|FD-Score:-4.44|P-value:9.36E-7 ID:SGTC_2816|Compound:7982706|FD-Score:3.50|P-value:9.41E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-3.13|P-value:3.94E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-6.51|P-value:1.48E-12 ID:SGTC_2984|Compound:9022109|FD-Score:3.23|P-value:2.85E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.99|P-value:7.11E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-3.40|P-value:1.30E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.72|P-value:3.58E-5 ID:SGTC_3193|Compound:9111931|FD-Score:3.63|P-value:5.33E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-5.04|P-value:3.20E-8 ID:SGTC_3198|Compound:9112019|FD-Score:3.51|P-value:8.93E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-4.48|P-value:7.58E-7 ID:SGTC_3223|Compound:9129970|FD-Score:3.00|P-value:6.87E-4 ID:SGTC_3356|Compound:9151811|FD-Score:2.94|P-value:8.50E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.96|P-value:5.57E-8 ID:SGTC_393|Compound:acivicin|FD-Score:3.05|P-value:5.68E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.86|P-value:1.74E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:2.97|P-value:7.50E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.00|P-value:6.80E-4 ID:SGTC_507|Compound:nimesulide|FD-Score:3.10|P-value:4.61E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.12|P-value:3.99E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:3.51|P-value:8.81E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:3.96|P-value:1.19E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:4.96|P-value:5.66E-8 ID:SGTC_795|Compound:0685-0265|FD-Score:-2.96|P-value:7.33E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:-2.90|P-value:9.29E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.52|P-value:8.43E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:3.54|P-value:7.88E-5 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.10|P-value:4.66E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.92|P-value:9.25E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.84|P-value:2.02E-5 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.00|P-value:6.24E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.46|P-value:1.11E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.43|P-value:1.22E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.15|P-value:3.78E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:4.35|P-value:1.64E-6 ID:SGTC_1553|Compound:gossypol|FD-Score:3.87|P-value:1.74E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.82|P-value:2.02E-5 ID:SGTC_2005|Compound:4024620|FD-Score:3.72|P-value:3.55E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.26|P-value:2.49E-4 ID:SGTC_2079|Compound:5212404|FD-Score:4.80|P-value:1.46E-7 ID:SGTC_2085|Compound:5307070|FD-Score:-4.23|P-value:2.84E-6 ID:SGTC_2087|Compound:5276107|FD-Score:2.90|P-value:9.73E-4 ID:SGTC_2248|Compound:tofa|FD-Score:5.14|P-value:1.90E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.13|P-value:3.91E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:4.90|P-value:7.95E-8 ID:SGTC_2318|Compound:6029776|FD-Score:4.70|P-value:2.60E-7 ID:SGTC_2320|Compound:7373003|FD-Score:6.24|P-value:1.24E-11 ID:SGTC_2321|Compound:7390090|FD-Score:-2.91|P-value:8.80E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.36|P-value:1.67E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.10|P-value:2.45E-8 ID:SGTC_2556|Compound:citropten|FD-Score:6.88|P-value:9.01E-14 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.64|P-value:4.65E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-5.19|P-value:1.25E-8 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.15|P-value:3.81E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.52|P-value:8.38E-5 ID:SGTC_2807|Compound:7945238|FD-Score:5.15|P-value:1.82E-8 ID:SGTC_2809|Compound:7964133|FD-Score:-4.44|P-value:9.36E-7 ID:SGTC_2816|Compound:7982706|FD-Score:3.50|P-value:9.41E-5 ID:SGTC_2823|Compound:7987624|FD-Score:-3.13|P-value:3.94E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-6.51|P-value:1.48E-12 ID:SGTC_2984|Compound:9022109|FD-Score:3.23|P-value:2.85E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.99|P-value:7.11E-4 ID:SGTC_3118|Compound:9124250|FD-Score:-3.40|P-value:1.30E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.72|P-value:3.58E-5 ID:SGTC_3193|Compound:9111931|FD-Score:3.63|P-value:5.33E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-5.04|P-value:3.20E-8 ID:SGTC_3198|Compound:9112019|FD-Score:3.51|P-value:8.93E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-4.48|P-value:7.58E-7 ID:SGTC_3223|Compound:9129970|FD-Score:3.00|P-value:6.87E-4 ID:SGTC_3356|Compound:9151811|FD-Score:2.94|P-value:8.50E-4

Top fitness defect scores for YIL163C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2556 citropten 6.88 84.6 µM 9.01E-14 1 2.90E-12
2 SGTC_2320 7373003 6.24 200.0 µM 1.24E-11 3 2.17E-10
3 SGTC_2807 7945238 5.15 52.0 µM 1.82E-8 9 1.29E-7
4 SGTC_2248 tofa 5.14 1.1 µM 1.90E-8 sphingolipid biosynthesis & PDR1 25 1.34E-7
5 SGTC_2540 epiandrosterone 5.10 100.0 µM 2.45E-8 32 1.67E-7
6 SGTC_161 4065-0411 4.96 162.2 µM 5.57E-8 42 3.44E-7
7 SGTC_780 0109-0199 4.96 192.0 µM 5.66E-8 3 3.48E-7
8 SGTC_2252 omeprazole 4.90 400.0 µM 7.95E-8 3 4.69E-7
9 SGTC_2079 5212404 4.80 121.0 µM 1.46E-7 4 8.00E-7
10 SGTC_2318 6029776 4.70 164.0 µM 2.60E-7 13 1.33E-6
11 SGTC_1490 4089-0339 4.35 670.0 nM 1.64E-6 4 6.69E-6
12 SGTC_776 4476-4378 3.96 112.0 µM 1.19E-5 ERG2 17 3.82E-5
13 SGTC_1553 gossypol 3.87 38.6 µM 1.74E-5 2 5.35E-5
14 SGTC_1039 k821-0043 3.84 94.0 µM 2.02E-5 Golgi 27 6.09E-5
15 SGTC_2005 4024620 3.72 188.0 µM 3.55E-5 26 1.00E-4
16 SGTC_3189 9110682 3.72 49.5 µM 3.58E-5 45 1.01E-4
17 SGTC_3193 9111931 3.63 49.5 µM 5.33E-5 34 1.43E-4
18 SGTC_929 2805-0021 3.54 398.0 µM 7.88E-5 18 2.02E-4
19 SGTC_2660 2',4'-dihydroxychalcone 3.52 17.1 µM 8.38E-5 31 2.13E-4
20 SGTC_827 3253-0474 3.52 693.0 µM 8.43E-5 32 2.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.61E-9 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.096 2.88E-8 YMR002W MIC17 hom Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.093 6.82E-8 YNL093W YPT53 hom Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication
0.088 2.83E-7 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.088 3.09E-7 YLR086W SMC4 het Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate
0.086 6.55E-7 YDL173W PAR32 hom Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene
0.085 9.37E-7 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.080 3.81E-6 YER177W BMH1 hom 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.079 4.66E-6 YPR072W NOT5 hom Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
0.074 1.72E-5 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.074 1.89E-5 YGR119C NUP57 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)
0.073 2.53E-5 YHL017W_p YHL017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication
0.072 3.24E-5 YDL182W LYS20 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication
0.071 3.52E-5 YJL074C SMC3 het Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
0.070 4.71E-5 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation