YIL165C_p

Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL165C / YIL165C

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:-2.93|P-value:8.92E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.58|P-value:6.70E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.70|P-value:2.29E-7 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.56|P-value:4.97E-7 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-3.69|P-value:4.27E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.80|P-value:2.52E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:2.98|P-value:6.73E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.67|P-value:4.09E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:3.12|P-value:3.93E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.95|P-value:1.14E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.17|P-value:3.64E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.77|P-value:2.57E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.48|P-value:1.03E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.45|P-value:1.18E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.82|P-value:2.01E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.90|P-value:1.61E-5 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.49|P-value:9.07E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.31|P-value:1.88E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.42|P-value:1.36E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.06|P-value:4.97E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-2.93|P-value:9.06E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.76|P-value:2.66E-5 ID:SGTC_1736|Compound:st036774|FD-Score:4.70|P-value:2.30E-7 ID:SGTC_1786|Compound:berberine|FD-Score:3.09|P-value:4.57E-4 ID:SGTC_2143|Compound:5623677|FD-Score:2.99|P-value:6.65E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.75|P-value:2.79E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.25|P-value:2.43E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.53|P-value:8.34E-5 ID:SGTC_2402|Compound:5553605|FD-Score:4.36|P-value:1.41E-6 ID:SGTC_2436|Compound:5633522|FD-Score:-2.91|P-value:9.71E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.36|P-value:1.51E-4 ID:SGTC_2445|Compound:5742597|FD-Score:2.97|P-value:7.06E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.70|P-value:3.51E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.26|P-value:2.55E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.09|P-value:4.46E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-3.03|P-value:6.31E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.51|P-value:9.09E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.39|P-value:1.51E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.62|P-value:5.00E-5 ID:SGTC_3101|Compound:9120531|FD-Score:3.01|P-value:6.18E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.71|P-value:3.91E-5 ID:SGTC_11|Compound:0438-0307|FD-Score:-2.93|P-value:8.92E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.58|P-value:6.70E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.70|P-value:2.29E-7 ID:SGTC_234|Compound:nsc-17383|FD-Score:4.56|P-value:4.97E-7 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:-3.69|P-value:4.27E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.80|P-value:2.52E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:2.98|P-value:6.73E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.67|P-value:4.09E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:3.12|P-value:3.93E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.95|P-value:1.14E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.17|P-value:3.64E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.77|P-value:2.57E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.48|P-value:1.03E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.45|P-value:1.18E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.82|P-value:2.01E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.90|P-value:1.61E-5 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.49|P-value:9.07E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.31|P-value:1.88E-6 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.42|P-value:1.36E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.06|P-value:4.97E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-2.93|P-value:9.06E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.76|P-value:2.66E-5 ID:SGTC_1736|Compound:st036774|FD-Score:4.70|P-value:2.30E-7 ID:SGTC_1786|Compound:berberine|FD-Score:3.09|P-value:4.57E-4 ID:SGTC_2143|Compound:5623677|FD-Score:2.99|P-value:6.65E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.75|P-value:2.79E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.25|P-value:2.43E-4 ID:SGTC_2340|Compound:7987427|FD-Score:-3.53|P-value:8.34E-5 ID:SGTC_2402|Compound:5553605|FD-Score:4.36|P-value:1.41E-6 ID:SGTC_2436|Compound:5633522|FD-Score:-2.91|P-value:9.71E-4 ID:SGTC_2439|Compound:5492030|FD-Score:3.36|P-value:1.51E-4 ID:SGTC_2445|Compound:5742597|FD-Score:2.97|P-value:7.06E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.70|P-value:3.51E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.26|P-value:2.55E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.09|P-value:4.46E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-3.03|P-value:6.31E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.51|P-value:9.09E-5 ID:SGTC_3044|Compound:9093193|FD-Score:-3.39|P-value:1.51E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.62|P-value:5.00E-5 ID:SGTC_3101|Compound:9120531|FD-Score:3.01|P-value:6.18E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.71|P-value:3.91E-5

Top fitness defect scores for YIL165C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 4.70 2.7 µM 2.29E-7 mitochondrial stress 161 1.30E-6
2 SGTC_1736 st036774 4.70 51.0 µM 2.30E-7 19 1.30E-6
3 SGTC_234 nsc-17383 4.56 10.7 µM 4.97E-7 ERG2 16 2.56E-6
4 SGTC_2402 5553605 4.36 200.0 µM 1.41E-6 13 6.38E-6
5 SGTC_1503 4585-0012 4.31 61.3 µM 1.88E-6 9 8.22E-6
6 SGTC_651 3253-0966 3.95 34.4 µM 1.14E-5 calcium & mitochondrial duress 33 3.99E-5
7 SGTC_1125 tnp00248 3.82 1.3 µM 2.01E-5 32 6.54E-5
8 SGTC_950 1165-0508 3.77 94.1 µM 2.57E-5 32 8.10E-5
9 SGTC_1727 st034309 3.76 9.9 µM 2.66E-5 50 8.36E-5
10 SGTC_2255 7941087 3.75 197.4 µM 2.79E-5 36 8.72E-5
11 SGTC_2613 3',4'-dimethoxydalbergione 3.70 24.6 µM 3.51E-5 30 1.07E-4
12 SGTC_523 1934-0222 3.67 13.7 µM 4.09E-5 38 1.22E-4
13 SGTC_3066 9117245 3.62 49.5 µM 5.00E-5 17 1.45E-4
14 SGTC_1482 3346-2049 3.49 8.5 µM 9.07E-5 40 2.45E-4
15 SGTC_2439 5492030 3.36 7.2 µM 1.51E-4 30 3.85E-4
16 SGTC_2261 9010538 3.25 184.7 µM 2.43E-4 33 5.82E-4
17 SGTC_638 3970-0837 3.12 4.1 µM 3.93E-4 79 8.90E-4
18 SGTC_2814 7977482 3.09 43.0 µM 4.46E-4 99 9.94E-4
19 SGTC_1786 berberine 3.09 21.6 µM 4.57E-4 60S ribosome export 85 0.00101
20 SGTC_1513 0337-0559 3.06 19.0 µM 4.97E-4 53 0.00109

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.12E-13 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.123 8.40E-13 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.118 8.15E-12 YDR097C MSH6 hom Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p
0.116 1.41E-11 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.114 3.66E-11 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.113 5.61E-11 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.109 2.32E-10 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.109 2.37E-10 YJL208C NUC1 hom Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
0.104 1.35E-9 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.100 6.41E-9 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.100 7.41E-9 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.100 7.57E-9 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.098 1.49E-8 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.097 1.63E-8 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.097 1.85E-8 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology