YIL166C_p

Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YIL166C / YIL166C

Click on Significant Values for Screen Details ID:SGTC_599|Compound:1935-0052|FD-Score:-3.20|P-value:8.17E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.69|P-value:1.30E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.76|P-value:9.98E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.29|P-value:5.77E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.05|P-value:3.15E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.48|P-value:2.91E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.21|P-value:7.41E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.44|P-value:3.37E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.25|P-value:6.77E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.19|P-value:8.35E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.15|P-value:9.63E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.19|P-value:1.60E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.61|P-value:1.91E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.16|P-value:8.73E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.19|P-value:8.37E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.08|P-value:2.80E-5 ID:SGTC_1819|Compound:st053448|FD-Score:3.15|P-value:9.07E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.34|P-value:4.73E-4 ID:SGTC_2079|Compound:5212404|FD-Score:3.18|P-value:8.25E-4 ID:SGTC_2081|Compound:5214970|FD-Score:5.22|P-value:1.22E-7 ID:SGTC_2212|Compound:7123476|FD-Score:-3.37|P-value:4.49E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.36|P-value:4.64E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.63|P-value:1.65E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.20|P-value:7.63E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:7.17|P-value:7.03E-13 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-4.02|P-value:3.70E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.18|P-value:8.38E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.15|P-value:9.23E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.32|P-value:5.15E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.57|P-value:2.07E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.97|P-value:4.33E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.75|P-value:1.04E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.75|P-value:1.12E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.58|P-value:2.03E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-4.35|P-value:9.11E-6 ID:SGTC_3354|Compound:9151612|FD-Score:-3.23|P-value:7.25E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.20|P-value:8.17E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.69|P-value:1.30E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.76|P-value:9.98E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:3.29|P-value:5.77E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.05|P-value:3.15E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.48|P-value:2.91E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.21|P-value:7.41E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.44|P-value:3.37E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.25|P-value:6.77E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.19|P-value:8.35E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.15|P-value:9.63E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.19|P-value:1.60E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.61|P-value:1.91E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.16|P-value:8.73E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-3.19|P-value:8.37E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.08|P-value:2.80E-5 ID:SGTC_1819|Compound:st053448|FD-Score:3.15|P-value:9.07E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.57|P-value:2.05E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.34|P-value:4.73E-4 ID:SGTC_2079|Compound:5212404|FD-Score:3.18|P-value:8.25E-4 ID:SGTC_2081|Compound:5214970|FD-Score:5.22|P-value:1.22E-7 ID:SGTC_2212|Compound:7123476|FD-Score:-3.37|P-value:4.49E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.36|P-value:4.64E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.63|P-value:1.65E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.20|P-value:7.63E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:7.17|P-value:7.03E-13 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-4.02|P-value:3.70E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.18|P-value:8.38E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.15|P-value:9.23E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.32|P-value:5.15E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.57|P-value:2.07E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.97|P-value:4.33E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.75|P-value:1.04E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.75|P-value:1.12E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.58|P-value:2.03E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-4.35|P-value:9.11E-6 ID:SGTC_3354|Compound:9151612|FD-Score:-3.23|P-value:7.25E-4

Top fitness defect scores for YIL166C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2607 solasodine 7.17 47.4 µM 7.03E-13 19 3.73E-13
2 SGTC_2081 5214970 5.22 32.3 µM 1.22E-7 7 8.75E-8
3 SGTC_1784 st039334 4.08 36.3 µM 2.80E-5 16 2.30E-5
4 SGTC_636 0kpi-0074 4.05 126.0 µM 3.15E-5 18 2.59E-5
5 SGTC_2929 9013348 3.97 24.6 µM 4.33E-5 18 3.59E-5
6 SGTC_606 k015-0008 3.76 38.6 µM 9.98E-5 18 8.43E-5
7 SGTC_3067 9117431 3.75 49.5 µM 1.04E-4 16 8.82E-5
8 SGTC_604 1000-0114 3.69 314.0 µM 1.30E-4 32 1.10E-4
9 SGTC_2517 totarol 3.63 10.0 µM 1.65E-4 29 1.41E-4
10 SGTC_3343 9148379 3.58 19.0 µM 2.03E-4 11 1.74E-4
11 SGTC_2014 4013930 3.57 200.0 µM 2.05E-4 57 1.76E-4
12 SGTC_2922 7999257 3.57 32.5 µM 2.07E-4 18 1.78E-4
13 SGTC_656 4090-1979 3.48 187.0 µM 2.91E-4 33 2.52E-4
14 SGTC_989 1501-0895 3.44 10.3 µM 3.37E-4 17 2.93E-4
15 SGTC_2018 5133068 3.34 143.0 µM 4.73E-4 44 4.15E-4
16 SGTC_2787 5284540 3.32 71.4 µM 5.15E-4 49 4.52E-4
17 SGTC_626 0214-0009 3.29 33.0 µM 5.77E-4 copper-dependent oxidative stress 42 5.08E-4
18 SGTC_929 2805-0021 3.21 398.0 µM 7.41E-4 35 6.56E-4
19 SGTC_2606 farnesol 3.20 9.8 µM 7.63E-4 51 6.76E-4
20 SGTC_2079 5212404 3.18 121.0 µM 8.25E-4 26 7.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 1.12E-34 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.197 1.49E-30 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.190 1.17E-28 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.185 2.48E-27 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.184 5.45E-27 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.184 7.49E-27 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.175 2.08E-24 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.167 1.61E-22 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.160 9.25E-21 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.156 1.13E-19 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.155 1.36E-19 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2
0.154 2.25E-19 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.154 2.63E-19 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.149 4.04E-18 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.148 6.79E-18 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data