YIR001C / SGN1

Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR001C / SGN1

Click on Significant Values for Screen Details ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.08|P-value:7.42E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.36|P-value:2.64E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.23|P-value:3.50E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.73|P-value:5.91E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.13|P-value:6.17E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.24|P-value:4.18E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.27|P-value:3.68E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.04|P-value:7.05E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.30|P-value:3.27E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.03|P-value:9.05E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.58|P-value:1.10E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.32|P-value:3.09E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.10|P-value:7.06E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.02|P-value:7.67E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.40|P-value:2.25E-4 ID:SGTC_2070|Compound:5230947|FD-Score:-2.96|P-value:9.59E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.24|P-value:4.20E-4 ID:SGTC_2077|Compound:5212015|FD-Score:4.16|P-value:8.70E-6 ID:SGTC_2081|Compound:5214970|FD-Score:3.96|P-value:2.17E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-3.61|P-value:7.87E-5 ID:SGTC_2154|Compound:5570129|FD-Score:3.32|P-value:3.09E-4 ID:SGTC_2444|Compound:5485484|FD-Score:-3.91|P-value:2.11E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.02|P-value:9.24E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.09|P-value:1.18E-5 ID:SGTC_2794|Compound:7785382|FD-Score:4.86|P-value:2.51E-7 ID:SGTC_2841|Compound:9004761|FD-Score:4.35|P-value:3.37E-6 ID:SGTC_2947|Compound:9072639|FD-Score:4.39|P-value:2.89E-6 ID:SGTC_2988|Compound:9073640|FD-Score:3.02|P-value:9.13E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.42|P-value:2.47E-6 ID:SGTC_3087|Compound:9117406|FD-Score:3.50|P-value:1.53E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.10|P-value:6.95E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.63|P-value:9.08E-5 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.08|P-value:7.42E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.36|P-value:2.64E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.23|P-value:3.50E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.73|P-value:5.91E-5 ID:SGTC_389|Compound:tpck|FD-Score:3.13|P-value:6.17E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.24|P-value:4.18E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.27|P-value:3.68E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.04|P-value:7.05E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.30|P-value:3.27E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.03|P-value:9.05E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.58|P-value:1.10E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.32|P-value:3.09E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.10|P-value:7.06E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.02|P-value:7.67E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.40|P-value:2.25E-4 ID:SGTC_2070|Compound:5230947|FD-Score:-2.96|P-value:9.59E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.24|P-value:4.20E-4 ID:SGTC_2077|Compound:5212015|FD-Score:4.16|P-value:8.70E-6 ID:SGTC_2081|Compound:5214970|FD-Score:3.96|P-value:2.17E-5 ID:SGTC_2082|Compound:5219693|FD-Score:-3.61|P-value:7.87E-5 ID:SGTC_2154|Compound:5570129|FD-Score:3.32|P-value:3.09E-4 ID:SGTC_2444|Compound:5485484|FD-Score:-3.91|P-value:2.11E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.02|P-value:9.24E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.09|P-value:1.18E-5 ID:SGTC_2794|Compound:7785382|FD-Score:4.86|P-value:2.51E-7 ID:SGTC_2841|Compound:9004761|FD-Score:4.35|P-value:3.37E-6 ID:SGTC_2947|Compound:9072639|FD-Score:4.39|P-value:2.89E-6 ID:SGTC_2988|Compound:9073640|FD-Score:3.02|P-value:9.13E-4 ID:SGTC_3067|Compound:9117431|FD-Score:4.42|P-value:2.47E-6 ID:SGTC_3087|Compound:9117406|FD-Score:3.50|P-value:1.53E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.10|P-value:6.95E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.63|P-value:9.08E-5

Top fitness defect scores for YIR001C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2794 7785382 4.86 27.3 µM 2.51E-7 9 5.93E-7
2 SGTC_3067 9117431 4.42 49.5 µM 2.47E-6 3 4.99E-6
3 SGTC_2947 9072639 4.39 7.7 µM 2.89E-6 tubulin folding & SWR complex 31 5.78E-6
4 SGTC_2841 9004761 4.35 39.0 µM 3.37E-6 amide catabolism 17 6.68E-6
5 SGTC_2077 5212015 4.16 200.0 µM 8.70E-6 61 1.62E-5
6 SGTC_2782 7736369 4.09 71.4 µM 1.18E-5 34 2.15E-5
7 SGTC_2081 5214970 3.96 32.3 µM 2.17E-5 25 3.79E-5
8 SGTC_365 0121-0052 3.73 13.6 µM 5.91E-5 mitochondrial response to ROS 64 9.67E-5
9 SGTC_3217 9129673 3.63 49.5 µM 9.08E-5 53 1.44E-4
10 SGTC_1155 4088-0394 3.58 48.2 µM 1.10E-4 43 1.72E-4
11 SGTC_3087 9117406 3.50 49.5 µM 1.53E-4 33 2.36E-4
12 SGTC_2004 4023728 3.40 41.9 µM 2.25E-4 46 3.38E-4
13 SGTC_302 1094-0063 3.36 18.9 µM 2.64E-4 24 3.91E-4
14 SGTC_1885 st057546 3.32 99.9 µM 3.09E-4 36 4.54E-4
15 SGTC_2154 5570129 3.32 200.0 µM 3.09E-4 44 4.54E-4
16 SGTC_662 k832-1615 3.30 104.0 µM 3.27E-4 47 4.79E-4
17 SGTC_457 grayanotoxin iii 3.27 135.0 µM 3.68E-4 117 5.34E-4
18 SGTC_444 curcumin 3.24 90.4 µM 4.18E-4 iron homeostasis 48 6.02E-4
19 SGTC_2074 5212007 3.24 75.4 µM 4.20E-4 32 6.05E-4
20 SGTC_389 tpck 3.13 16.7 µM 6.17E-4 64 8.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.87E-11 YFR006W_p YFR006W_p hom Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene
0.115 2.77E-11 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.110 1.88E-10 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.107 5.84E-10 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.105 1.09E-9 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.104 1.59E-9 YOL077C BRX1 het Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
0.099 1.03E-8 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.094 4.48E-8 YNL276C_d YNL276C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W
0.094 4.80E-8 YLR007W NSE1 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.094 5.16E-8 YJL142C_d IRC9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci
0.092 9.48E-8 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.085 7.67E-7 YIL166C_p YIL166C_p hom Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
0.084 1.01E-6 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.084 1.03E-6 YJL110C GZF3 hom GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication
0.083 1.41E-6 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction