YIR021W / MRS1

Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR021W / MRS1

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:3.04|P-value:4.20E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:11.70|P-value:1.08E-37 ID:SGTC_151|Compound:3013-0144|FD-Score:-8.94|P-value:1.18E-22 ID:SGTC_153|Compound:4077-0274|FD-Score:3.19|P-value:2.30E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.79|P-value:2.03E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.50|P-value:6.00E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:13.60|P-value:2.91E-50 ID:SGTC_283|Compound:0987-0079|FD-Score:3.03|P-value:4.34E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.88|P-value:1.00E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:4.18|P-value:2.32E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:13.80|P-value:1.47E-51 ID:SGTC_417|Compound:st075190|FD-Score:3.11|P-value:3.12E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-2.92|P-value:8.14E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.27|P-value:1.60E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-2.88|P-value:9.45E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.31|P-value:4.10E-9 ID:SGTC_761|Compound:k216-0224|FD-Score:3.40|P-value:9.30E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:2.93|P-value:6.35E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-2.93|P-value:7.57E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.31|P-value:1.70E-4 ID:SGTC_1115|Compound:galangin|FD-Score:2.99|P-value:5.00E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.84|P-value:9.02E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-4.66|P-value:2.20E-7 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.03|P-value:5.24E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:2.91|P-value:6.82E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.35|P-value:8.98E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.05|P-value:4.02E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-2.99|P-value:6.15E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.10|P-value:3.25E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.48|P-value:6.62E-5 ID:SGTC_1617|Compound:st002906|FD-Score:-3.45|P-value:9.30E-5 ID:SGTC_1635|Compound:st007035|FD-Score:14.60|P-value:7.58E-58 ID:SGTC_1713|Compound:st033146|FD-Score:3.06|P-value:3.82E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.65|P-value:3.85E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-3.84|P-value:1.59E-5 ID:SGTC_1976|Compound:st070609|FD-Score:3.16|P-value:2.55E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.25|P-value:2.16E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.03|P-value:4.26E-4 ID:SGTC_2426|Compound:5582046|FD-Score:9.69|P-value:1.54E-26 ID:SGTC_2427|Compound:5545055|FD-Score:-4.84|P-value:7.85E-8 ID:SGTC_2428|Compound:5615643|FD-Score:4.09|P-value:3.69E-6 ID:SGTC_2430|Compound:5571206|FD-Score:4.66|P-value:1.66E-7 ID:SGTC_2434|Compound:5670830|FD-Score:4.14|P-value:2.81E-6 ID:SGTC_2449|Compound:5812982|FD-Score:-3.05|P-value:4.80E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:2.96|P-value:5.61E-4 ID:SGTC_2476|Compound:5806916|FD-Score:2.89|P-value:7.29E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.17|P-value:2.51E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_2926|Compound:9010726|FD-Score:5.55|P-value:6.13E-10 ID:SGTC_2971|Compound:9092186|FD-Score:-2.90|P-value:8.75E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.01|P-value:4.61E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-3.80|P-value:1.90E-5 ID:SGTC_3202|Compound:9113761|FD-Score:2.91|P-value:6.95E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.90|P-value:8.58E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.04|P-value:4.22E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.04|P-value:4.20E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:11.70|P-value:1.08E-37 ID:SGTC_151|Compound:3013-0144|FD-Score:-8.94|P-value:1.18E-22 ID:SGTC_153|Compound:4077-0274|FD-Score:3.19|P-value:2.30E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.79|P-value:2.03E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.50|P-value:6.00E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:13.60|P-value:2.91E-50 ID:SGTC_283|Compound:0987-0079|FD-Score:3.03|P-value:4.34E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.88|P-value:1.00E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:4.18|P-value:2.32E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:13.80|P-value:1.47E-51 ID:SGTC_417|Compound:st075190|FD-Score:3.11|P-value:3.12E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-2.92|P-value:8.14E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.27|P-value:1.60E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-2.88|P-value:9.45E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.31|P-value:4.10E-9 ID:SGTC_761|Compound:k216-0224|FD-Score:3.40|P-value:9.30E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:2.93|P-value:6.35E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-2.93|P-value:7.57E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.31|P-value:1.70E-4 ID:SGTC_1115|Compound:galangin|FD-Score:2.99|P-value:5.00E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.84|P-value:9.02E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-4.66|P-value:2.20E-7 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.03|P-value:5.24E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:2.91|P-value:6.82E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.35|P-value:8.98E-7 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.05|P-value:4.02E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-2.99|P-value:6.15E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.10|P-value:3.25E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.48|P-value:6.62E-5 ID:SGTC_1617|Compound:st002906|FD-Score:-3.45|P-value:9.30E-5 ID:SGTC_1635|Compound:st007035|FD-Score:14.60|P-value:7.58E-58 ID:SGTC_1713|Compound:st033146|FD-Score:3.06|P-value:3.82E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.65|P-value:3.85E-5 ID:SGTC_1959|Compound:st077091|FD-Score:-3.84|P-value:1.59E-5 ID:SGTC_1976|Compound:st070609|FD-Score:3.16|P-value:2.55E-4 ID:SGTC_2026|Compound:5148700|FD-Score:-3.25|P-value:2.16E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.03|P-value:4.26E-4 ID:SGTC_2426|Compound:5582046|FD-Score:9.69|P-value:1.54E-26 ID:SGTC_2427|Compound:5545055|FD-Score:-4.84|P-value:7.85E-8 ID:SGTC_2428|Compound:5615643|FD-Score:4.09|P-value:3.69E-6 ID:SGTC_2430|Compound:5571206|FD-Score:4.66|P-value:1.66E-7 ID:SGTC_2434|Compound:5670830|FD-Score:4.14|P-value:2.81E-6 ID:SGTC_2449|Compound:5812982|FD-Score:-3.05|P-value:4.80E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:2.96|P-value:5.61E-4 ID:SGTC_2476|Compound:5806916|FD-Score:2.89|P-value:7.29E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.17|P-value:2.51E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_2926|Compound:9010726|FD-Score:5.55|P-value:6.13E-10 ID:SGTC_2971|Compound:9092186|FD-Score:-2.90|P-value:8.75E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.01|P-value:4.61E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-3.80|P-value:1.90E-5 ID:SGTC_3202|Compound:9113761|FD-Score:2.91|P-value:6.95E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.90|P-value:8.58E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.04|P-value:4.22E-4

Top fitness defect scores for YIR021W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 14.60 42.4 µM 7.58E-58 43 8.00E-49
2 SGTC_386 1509-0011 13.80 3.1 µM 1.47E-51 25 1.53E-43
3 SGTC_236 1509-0011 13.60 5.3 µM 2.91E-50 128 1.88E-42
4 SGTC_134 0269-0018 11.70 6.9 µM 1.08E-37 32 6.86E-32
5 SGTC_2426 5582046 9.69 32.2 µM 1.54E-26 1 1.62E-22
6 SGTC_2926 9010726 5.55 65.2 µM 6.13E-10 9 1.45E-8
7 SGTC_2430 5571206 4.66 200.0 µM 1.66E-7 38 1.61E-6
8 SGTC_1212 0520-0165 4.35 585.0 µM 8.98E-7 18 6.69E-6
9 SGTC_361 000s-0510 4.18 1.4 µM 2.32E-6 27 1.49E-5
10 SGTC_2434 5670830 4.14 169.9 µM 2.81E-6 21 1.75E-5
11 SGTC_2428 5615643 4.09 7.8 µM 3.69E-6 29 2.20E-5
12 SGTC_310 1273-0058 3.88 1.1 µM 1.00E-5 mitochondrial stress 249 5.12E-5
13 SGTC_230 MPP+ 3.50 141.7 µM 6.00E-5 28 2.31E-4
14 SGTC_1586 deoxycorticosterone acetate 3.48 53.7 µM 6.62E-5 25 2.51E-4
15 SGTC_761 k216-0224 3.40 480.0 µM 9.30E-5 44 3.35E-4
16 SGTC_2697 mebhydrolin 3.35 72.4 µM 1.18E-4 NEO1 94 4.09E-4
17 SGTC_593 1203-0218 3.27 61.7 µM 1.60E-4 27 5.30E-4
18 SGTC_153 4077-0274 3.19 519.7 µM 2.30E-4 38 7.20E-4
19 SGTC_2608 thymoquinone 3.17 42.7 µM 2.51E-4 44 7.73E-4
20 SGTC_1976 st070609 3.16 63.5 µM 2.55E-4 34 7.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.681 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.652 0 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.639 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.636 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.634 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.627 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.624 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.624 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.624 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.618 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.616 0 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.602 0 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.591 3.20E-314 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.588 7.64E-311 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.582 1.66E-302 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p