YIR024C

Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect

Zygosity: Homozygous strain
fixedexpanded
Profile for YIR024C / YIR024C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.59|P-value:5.93E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:7.71|P-value:8.48E-14 ID:SGTC_51|Compound:1013-0126|FD-Score:4.09|P-value:4.70E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:4.48|P-value:9.53E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.37|P-value:6.04E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.33|P-value:1.56E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.76|P-value:1.51E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:-3.47|P-value:4.31E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.50|P-value:7.60E-6 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.70|P-value:2.05E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:5.86|P-value:1.07E-8 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.28|P-value:8.16E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.96|P-value:6.95E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.26|P-value:9.22E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.72|P-value:1.95E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.27|P-value:2.31E-5 ID:SGTC_1848|Compound:st056003|FD-Score:6.09|P-value:2.91E-9 ID:SGTC_2015|Compound:5119600|FD-Score:-5.37|P-value:1.24E-7 ID:SGTC_2396|Compound:5342950|FD-Score:3.25|P-value:9.56E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.70|P-value:2.03E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.04|P-value:5.66E-5 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.65|P-value:2.44E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.17|P-value:3.39E-5 ID:SGTC_2887|Compound:9044784|FD-Score:4.49|P-value:9.09E-6 ID:SGTC_2938|Compound:9059746|FD-Score:3.56|P-value:3.36E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.80|P-value:1.41E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.59|P-value:3.02E-4 ID:SGTC_3099|Compound:9120367|FD-Score:3.43|P-value:5.25E-4 ID:SGTC_3185|Compound:9108267|FD-Score:-3.51|P-value:3.66E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.59|P-value:5.93E-6 ID:SGTC_42|Compound:0133-0086|FD-Score:7.71|P-value:8.48E-14 ID:SGTC_51|Compound:1013-0126|FD-Score:4.09|P-value:4.70E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:4.48|P-value:9.53E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.37|P-value:6.04E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.33|P-value:1.56E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.76|P-value:1.51E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:-3.47|P-value:4.31E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.50|P-value:7.60E-6 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.70|P-value:2.05E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:5.86|P-value:1.07E-8 ID:SGTC_1305|Compound:1181-0477|FD-Score:-3.28|P-value:8.16E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.96|P-value:6.95E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.26|P-value:9.22E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.72|P-value:1.95E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.27|P-value:2.31E-5 ID:SGTC_1848|Compound:st056003|FD-Score:6.09|P-value:2.91E-9 ID:SGTC_2015|Compound:5119600|FD-Score:-5.37|P-value:1.24E-7 ID:SGTC_2396|Compound:5342950|FD-Score:3.25|P-value:9.56E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.70|P-value:2.03E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.04|P-value:5.66E-5 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:3.65|P-value:2.44E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.17|P-value:3.39E-5 ID:SGTC_2887|Compound:9044784|FD-Score:4.49|P-value:9.09E-6 ID:SGTC_2938|Compound:9059746|FD-Score:3.56|P-value:3.36E-4 ID:SGTC_3033|Compound:9090887|FD-Score:3.80|P-value:1.41E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.59|P-value:3.02E-4 ID:SGTC_3099|Compound:9120367|FD-Score:3.43|P-value:5.25E-4 ID:SGTC_3185|Compound:9108267|FD-Score:-3.51|P-value:3.66E-4

Top fitness defect scores for YIR024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_42 0133-0086 7.71 60.6 µM 8.48E-14 1 6.43E-15
2 SGTC_1848 st056003 6.09 16.4 µM 2.91E-9 1 5.64E-10
3 SGTC_1300 1094-0077 5.86 113.0 µM 1.07E-8 2 2.33E-9
4 SGTC_35 0133-0054 4.59 64.1 µM 5.93E-6 16 2.27E-6
5 SGTC_2887 9044784 4.49 58.4 µM 9.09E-6 fatty acid desaturase (OLE1) 19 3.61E-6
6 SGTC_62 0180-0423 4.48 3.2 µM 9.53E-6 60S ribosome export 10 3.80E-6
7 SGTC_1454 4239-0054 4.27 42.6 µM 2.31E-5 25 9.96E-6
8 SGTC_2729 fluphenazine 4.17 10.7 µM 3.39E-5 9 1.51E-5
9 SGTC_51 1013-0126 4.09 23.4 µM 4.70E-5 28 2.16E-5
10 SGTC_2611 pyromycin 4.04 23.9 µM 5.66E-5 25 2.64E-5
11 SGTC_3033 9090887 3.80 49.5 µM 1.41E-4 fatty acid desaturase (OLE1) 29 7.14E-5
12 SGTC_1359 1582-0056 3.72 520.0 nM 1.95E-4 26 1.01E-4
13 SGTC_2426 5582046 3.70 32.2 µM 2.03E-4 38 1.06E-4
14 SGTC_1187 1391-0724 3.70 117.0 µM 2.05E-4 amide catabolism 24 1.07E-4
15 SGTC_2728 chlorpromazine 3.65 9.2 µM 2.44E-4 5 1.29E-4
16 SGTC_3075 9116269 3.59 49.5 µM 3.02E-4 30 1.63E-4
17 SGTC_2938 9059746 3.56 27.3 µM 3.36E-4 fatty acid desaturase (OLE1) 52 1.83E-4
18 SGTC_3099 9120367 3.43 49.5 µM 5.25E-4 29 2.98E-4
19 SGTC_1344 1488-0097 3.26 29.1 µM 9.22E-4 37 5.49E-4
20 SGTC_2396 5342950 3.25 42.8 µM 9.56E-4 RSC complex & mRNA processing 78 5.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.13E-12 YNR071C_p YNR071C_p hom Putative aldose 1-epimerase
0.102 3.26E-9 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.090 2.11E-7 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.084 1.11E-6 YPL014W_p YPL014W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
0.081 2.99E-6 YNR062C_p YNR062C_p hom Putative membrane protein of unknown function
0.080 3.82E-6 YIL100W_d YIL100W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
0.072 3.25E-5 YEL057C_p YEL057C_p hom Protein of unknown function involved in telomere maintenance; target of UME6 regulation
0.071 4.07E-5 YOR267C HRK1 hom Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress
0.071 4.20E-5 YGR232W NAS6 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
0.070 4.76E-5 YGL030W RPL30 het Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
0.069 7.01E-5 YMR167W MLH1 hom Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer
0.068 7.74E-5 YNR053C NOG2 het Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
0.068 8.13E-5 YJL090C DPB11 het DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress
0.067 1.04E-4 YKR058W GLG1 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication
0.066 1.22E-4 YPR069C SPE3 hom Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells