Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YJL001W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.400 | 3.22E-129 | YFR050C | PRE4 | het | Beta 7 subunit of the 20S proteasome |
0.390 | 4.45E-122 | YER094C | PUP3 | het | Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 |
0.373 | 5.51E-111 | YGL011C | SCL1 | het | Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria |
0.339 | 1.13E-90 | YBL041W | PRE7 | het | Beta 6 subunit of the 20S proteasome |
0.332 | 2.91E-87 | YMR314W | PRE5 | het | Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
0.328 | 9.38E-85 | YGR253C | PUP2 | het | Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta |
0.327 | 1.48E-84 | YOL038W | PRE6 | het | Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress |
0.318 | 1.14E-79 | YER012W | PRE1 | het | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle |
0.313 | 2.73E-77 | YLR021W | IRC25 | hom | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions |
0.285 | 8.59E-64 | YOR362C | PRE10 | het | Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
0.273 | 3.49E-58 | YML092C | PRE8 | het | Alpha 2 subunit of the 20S proteasome |
0.207 | 7.46E-34 | YPR103W | PRE2 | het | Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome |
0.206 | 2.25E-33 | YJL193W_p | YJL193W_p | hom | Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect |
0.203 | 1.40E-32 | YPR146C_d | YPR146C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.197 | 8.65E-31 | YNR042W_d | YNR042W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 |